Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     299
XP_005262424                                                           20     299
NP_001010877                                                           17    3301
NP_001180557                                                           17    3301
XP_006726147                                                           17    3301
XP_006726146                                                           17    3301
XP_005275587                                                           17    3301
XP_006726145                                                           17    3301
XP_006726057                                                           17    3301
XP_006726056                                                           17    3301
XP_005275427                                                           17    3301
XP_006726055                                                           17    3301
XP_006725876                                                           17    3301
XP_006725875                                                           17    3301
XP_005275151                                                           17    3301
XP_006725874                                                           17    3301
XP_006725758                                                           17    3301
XP_006725757                                                           17    3301
XP_005274997                                                           17    3301
XP_006725756                                                           17    3301
XP_006725544                                                           17    3301
XP_006725543                                                           17    3301
XP_005272851                                                           17    3301
XP_006725542                                                           17    3301
XP_006725100                                                           17    3301
XP_006725099                                                           17    3301
XP_006725098                                                           17    3301
XP_006725097                                                           17    3301
XP_006723085                                                           17    3301
XP_006715132                                                           17    3301
XP_006715131                                                           17    3301
XP_005249076                                                           17    3301
XP_006715130                                                           17    3301
NP_078966                                                              17    4312
NP_694950                                                              16    7355
NP_001121775                                                           16    7355
NP_060217                                                              16    7355
NP_065741                                                              16    7355
XP_006719830                                                           16    7355
XP_006719829                                                           16    7355
XP_005266318                                                           16    7355
NP_000284                                                              15    9605
NP_001027005                                                           15    9605
NP_060364                                                              15    9605
NP_870992                                                              15    9605
NP_001007073                                                           15    9605
XP_005256041                                                           15    9605
XP_005256040                                                           15    9605
XP_006721057                                                           15    9605
XP_005254992                                                           15    9605
>NP_722576
          Length = 3080

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TMLPRESAM 9
            TMLPRES+M
Sbjct: 1496 TMLPRESSM 1504
>XP_005262424
          Length = 2875

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TMLPRESAM 9
            TMLPRES+M
Sbjct: 1291 TMLPRESSM 1299
>NP_001010877
          Length = 666

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>NP_001180557
          Length = 118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  TMLPRES 7
          T+LPRES
Sbjct: 20 TLLPRES 26
>XP_006726147
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006726146
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_005275587
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006726145
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006726057
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006726056
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_005275427
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006726055
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725876
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006725875
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_005275151
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725874
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725758
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006725757
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_005274997
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725756
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725544
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006725543
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_005272851
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725542
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725100
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006725099
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725098
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006725097
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006723085
          Length = 155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  TMLPRES 7
          T+LPRES
Sbjct: 57 TLLPRES 63
>XP_006715132
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 24 TQLPQESAL 32
>XP_006715131
          Length = 691

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_005249076
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>XP_006715130
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TMLPRESAM 9
          T LP+ESA+
Sbjct: 49 TQLPQESAL 57
>NP_078966
          Length = 14507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TMLPRESAM 9
            T +PR SAM
Sbjct: 6345 TSMPRSSAM 6353
>NP_694950
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPRESA 8
           LPRESA
Sbjct: 345 LPRESA 350
>NP_001121775
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPRESA 8
           LPRESA
Sbjct: 345 LPRESA 350
>NP_060217
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TMLPRESA 8
            T+LP ESA
Sbjct: 1919 TVLPSESA 1926
>NP_065741
          Length = 2617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TMLPRESA 8
            T+LP ESA
Sbjct: 1919 TVLPSESA 1926
>XP_006719830
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPRESA 8
           LPRESA
Sbjct: 345 LPRESA 350
>XP_006719829
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPRESA 8
           LPRESA
Sbjct: 345 LPRESA 350
>XP_005266318
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPRESA 8
           LPRESA
Sbjct: 345 LPRESA 350
>NP_000284
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TMLPRES 7
           ++LPRES
Sbjct: 281 SLLPRES 287
>NP_001027005
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TMLPRES 7
           ++LPRES
Sbjct: 274 SLLPRES 280
>NP_060364
          Length = 150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TMLPRE 6
           TMLP+E
Sbjct: 100 TMLPKE 105
>NP_870992
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TMLPRE 6
           TMLP+E
Sbjct: 100 TMLPKE 105
>NP_001007073
          Length = 146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TMLPRE 6
           TMLP+E
Sbjct: 100 TMLPKE 105
>XP_005256041
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TMLPRES 7
           ++LPRES
Sbjct: 274 SLLPRES 280
>XP_005256040
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TMLPRES 7
           ++LPRES
Sbjct: 281 SLLPRES 287
>XP_006721057
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TMLPRES 7
           T+LPRE+
Sbjct: 98  TILPRET 104
>XP_005254992
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TMLPRE 6
           TMLP+E
Sbjct: 100 TMLPKE 105
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.119    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 570,118
Number of extensions: 377
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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