Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           22     103
NP_000133                                                              22     103
XP_006713936                                                           22     103
XP_006713935                                                           22     103
XP_006713934                                                           22     103
XP_006713933                                                           22     103
XP_006713932                                                           22     103
XP_006713931                                                           22     103
NP_998812                                                              18    1482
NP_002002                                                              18    1482
XP_005265895                                                           18    1482
XP_005265894                                                           18    1482
NP_002325                                                              16    5631
XP_006718294                                                           16    5631
XP_005252980                                                           16    5631
NP_536347                                                              16    7355
NP_055462                                                              16    7355
NP_612422                                                              16    7355
NP_001128142                                                           16    7355
NP_001171928                                                           16    7355
NP_064620                                                              16    7355
NP_001136040                                                           16    7355
NP_853514                                                              16    7355
NP_001193942                                                           16    7355
NP_001171927                                                           16    7355
NP_005099                                                              16    7355
NP_002819                                                              16    7355
NP_536348                                                              16    7355
XP_006725283                                                           16    7355
XP_006725281                                                           16    7355
XP_006725280                                                           16    7355
XP_006725279                                                           16    7355
XP_006725278                                                           16    7355
XP_005258182                                                           16    7355
XP_005258181                                                           16    7355
XP_006721049                                                           16    7355
XP_005255764                                                           16    7355
XP_005255763                                                           16    7355
XP_005255762                                                           16    7355
XP_005255761                                                           16    7355
XP_006713772                                                           16    7355
XP_006713771                                                           16    7355
XP_005247703                                                           16    7355
XP_006713770                                                           16    7355
XP_006713769                                                           16    7355
XP_005247702                                                           16    7355
XP_005247701                                                           16    7355
XP_005247700                                                           16    7355
XP_005247699                                                           16    7355
XP_006713513                                                           16    7355
XP_006713512                                                           16    7355
XP_006713511                                                           16    7355
NP_067648                                                              16    7355
NP_060627                                                              15    9605
NP_002103                                                              15    9605
NP_005384                                                              15    9605
NP_001156729                                                           15    9605
NP_004067                                                              15    9605
XP_005272668                                                           15    9605
XP_005272667                                                           15    9605
XP_006724596                                                           15    9605
XP_005269056                                                           15    9605
XP_005269055                                                           15    9605
XP_006718856                                                           15    9605
XP_006718855                                                           15    9605
XP_006718854                                                           15    9605
XP_006718853                                                           15    9605
XP_005271510                                                           15    9605
XP_005271509                                                           15    9605
XP_006718852                                                           15    9605
XP_006718851                                                           15    9605
NP_658988                                                              15    9605
>NP_001156685
          Length = 808

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 412 TVHKISRFP 420
>NP_000133
          Length = 806

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 410 TVHKISRFP 418
>XP_006713936
          Length = 807

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 410 TVHKISRFP 418
>XP_006713935
          Length = 807

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 410 TVHKISRFP 418
>XP_006713934
          Length = 809

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 412 TVHKISRFP 420
>XP_006713933
          Length = 810

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 412 TVHKISRFP 420
>XP_006713932
          Length = 810

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 412 TVHKISRFP 420
>XP_006713931
          Length = 811

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TMHKISRFP 9
           T+HKISRFP
Sbjct: 412 TVHKISRFP 420
>NP_998812
          Length = 802

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TMHKISRFP 9
           T+ K+SRFP
Sbjct: 405 TVQKLSRFP 413
>NP_002002
          Length = 802

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TMHKISRFP 9
           T+ K+SRFP
Sbjct: 405 TVQKLSRFP 413
>XP_005265895
          Length = 802

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TMHKISRFP 9
           T+ K+SRFP
Sbjct: 405 TVQKLSRFP 413
>XP_005265894
          Length = 834

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TMHKISRFP 9
           T+ K+SRFP
Sbjct: 437 TVQKLSRFP 445
>NP_002325
          Length = 1905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TMHKISR 7
            T+H+ISR
Sbjct: 1101 TLHRISR 1107
>XP_006718294
          Length = 1808

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TMHKISR 7
            T+H+ISR
Sbjct: 1101 TLHRISR 1107
>XP_005252980
          Length = 1809

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TMHKISR 7
            T+H+ISR
Sbjct: 1101 TLHRISR 1107
>NP_536347
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  HKISRFP 9
          H++++FP
Sbjct: 34 HRVAKFP 40
>NP_055462
          Length = 1742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>NP_612422
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  MHKISRFP 9
          +HK+  FP
Sbjct: 61 LHKLGTFP 68
>NP_001128142
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  MHKISRFP 9
          +HK+  FP
Sbjct: 61 LHKLGTFP 68
>NP_001171928
          Length = 1739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>NP_064620
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>NP_001136040
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>NP_853514
          Length = 1732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HKISRFP 9
           H IS+FP
Sbjct: 201 HPISQFP 207
>NP_001193942
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  HKISRFP 9
          H++++FP
Sbjct: 34 HRVAKFP 40
>NP_001171927
          Length = 1742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>NP_005099
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HKISRFP 9
           HK++ FP
Sbjct: 397 HKVAAFP 403
>NP_002819
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  HKISRFP 9
          H++++FP
Sbjct: 34 HRVAKFP 40
>NP_536348
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  HKISRFP 9
          H++++FP
Sbjct: 34 HRVAKFP 40
>XP_006725283
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_006725281
          Length = 1733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_006725280
          Length = 1741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_006725279
          Length = 1743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_006725278
          Length = 1743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_005258182
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  HKISRFP 9
          H++++FP
Sbjct: 34 HRVAKFP 40
>XP_005258181
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  HKISRFP 9
          H++++FP
Sbjct: 34 HRVAKFP 40
>XP_006721049
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_005255764
          Length = 1733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_005255763
          Length = 1741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_005255762
          Length = 1743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_005255761
          Length = 1743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           +HK+ +FP
Sbjct: 206 VHKLHQFP 213
>XP_006713772
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_006713771
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_005247703
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_006713770
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_006713769
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_005247702
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_005247701
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_005247700
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_005247699
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK S FP
Sbjct: 401 HKCSHFP 407
>XP_006713513
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HKISRFP 9
           HK++ FP
Sbjct: 260 HKVAAFP 266
>XP_006713512
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HKISRFP 9
           HK++ FP
Sbjct: 397 HKVAAFP 403
>XP_006713511
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HKISRFP 9
           HK++ FP
Sbjct: 370 HKVAAFP 376
>NP_067648
          Length = 135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  HKISRFP 9
          H++S FP
Sbjct: 27 HRLSNFP 33
>NP_060627
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TMHKISRFP 9
           ++ K+S FP
Sbjct: 104 SLEKVSEFP 112
>NP_002103
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TMHKISRF 8
           T HK+S F
Sbjct: 561 TKHKLSSF 568
>NP_005384
          Length = 1909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   TMHKISRFP 9
           T H++ R P
Sbjct: 462 TAHQVDRIP 470
>NP_001156729
          Length = 1932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   TMHKISRFP 9
           T H++ R P
Sbjct: 485 TAHQVDRIP 493
>NP_004067
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   HKISRFP 9
           HK  RFP
Sbjct: 203 HKRGRFP 209
>XP_005272668
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KISRFP 9
          KIS+FP
Sbjct: 11 KISKFP 16
>XP_005272667
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KISRFP 9
          KIS+FP
Sbjct: 11 KISKFP 16
>XP_006724596
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KISRFP 9
          KIS+FP
Sbjct: 11 KISKFP 16
>XP_005269056
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TMHKISRFP 9
           ++ K+S FP
Sbjct: 104 SLEKVSEFP 112
>XP_005269055
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TMHKISRFP 9
           ++ K+S FP
Sbjct: 104 SLEKVSEFP 112
>XP_006718856
          Length = 1976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>XP_006718855
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 530 MVKISRWP 537
>XP_006718854
          Length = 1999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>XP_006718853
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>XP_005271510
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>XP_005271509
          Length = 2024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>XP_006718852
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>XP_006718851
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHKISRFP 9
           M KISR+P
Sbjct: 576 MVKISRWP 583
>NP_658988
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TMHKISRF 8
           T+H +SR+
Sbjct: 796 TLHALSRY 803
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.137    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 562,853
Number of extensions: 1056
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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