Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     229
XP_006718908                                                           21     229
XP_005271621                                                           21     229
XP_006718907                                                           21     229
XP_006718906                                                           21     229
XP_005271619                                                           21     229
XP_005271618                                                           21     229
NP_060024                                                              17    2528
XP_005247602                                                           17    2528
NP_001096082                                                           16    5631
NP_001231191                                                           16    5631
XP_005250324                                                           16    5631
XP_005250323                                                           16    5631
NP_036389                                                              16    5631
NP_078808                                                              16    7355
NP_694580                                                              16    7355
NP_001106995                                                           16    7355
NP_689828                                                              16    7355
XP_006713581                                                           16    7355
XP_005247218                                                           16    7355
XP_005247217                                                           16    7355
XP_005247216                                                           16    7355
XP_006712810                                                           16    7355
XP_006712809                                                           16    7355
XP_006712808                                                           16    7355
XP_006712807                                                           16    7355
NP_006772                                                              15    9605
NP_001273404                                                           15    9605
NP_001273403                                                           15    9605
XP_006726136                                                           15    9605
XP_006726043                                                           15    9605
XP_006726042                                                           15    9605
XP_006726041                                                           15    9605
XP_005275399                                                           15    9605
XP_006726040                                                           15    9605
XP_006726039                                                           15    9605
XP_006726038                                                           15    9605
XP_006726037                                                           15    9605
XP_006726036                                                           15    9605
XP_006726035                                                           15    9605
XP_006725865                                                           15    9605
XP_006725864                                                           15    9605
XP_006725863                                                           15    9605
XP_006725862                                                           15    9605
XP_006725861                                                           15    9605
XP_006725860                                                           15    9605
XP_006725859                                                           15    9605
XP_006725858                                                           15    9605
XP_005275135                                                           15    9605
XP_006725744                                                           15    9605
XP_006725743                                                           15    9605
XP_006725742                                                           15    9605
XP_005274969                                                           15    9605
XP_006725741                                                           15    9605
XP_006725740                                                           15    9605
XP_006725739                                                           15    9605
XP_006725738                                                           15    9605
XP_006725737                                                           15    9605
XP_006725736                                                           15    9605
XP_006725529                                                           15    9605
XP_006715028                                                           15    9605
XP_006715027                                                           15    9605
XP_006715026                                                           15    9605
XP_006715025                                                           15    9605
XP_006715024                                                           15    9605
XP_006715023                                                           15    9605
XP_006715022                                                           15    9605
XP_006715021                                                           15    9605
XP_005248867                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 2666 TMEIKVDH 2673
>XP_006718908
          Length = 1708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 1318 TMEIKVDH 1325
>XP_005271621
          Length = 2708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 2318 TMEIKVDH 2325
>XP_006718907
          Length = 3050

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 2660 TMEIKVDH 2667
>XP_006718906
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 2666 TMEIKVDH 2673
>XP_005271619
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 2666 TMEIKVDH 2673
>XP_005271618
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TMEIKVDH 8
            TMEIKVDH
Sbjct: 2666 TMEIKVDH 2673
>NP_060024
          Length = 1801

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    TMEIKVDHR 9
            T+++K++HR
Sbjct: 1566 TVDVKINHR 1574
>XP_005247602
          Length = 1665

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    TMEIKVDHR 9
            T+++K++HR
Sbjct: 1430 TVDVKINHR 1438
>NP_001096082
          Length = 196

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TMEIKVDHR 9
          T+E+ VD+R
Sbjct: 24 TLELPVDYR 32
>NP_001231191
          Length = 524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TMEIKVDH 8
           T+E K+DH
Sbjct: 303 TVECKLDH 310
>XP_005250324
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TMEIKVDH 8
           T+E K+DH
Sbjct: 293 TVECKLDH 300
>XP_005250323
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TMEIKVDH 8
           T+E K+DH
Sbjct: 293 TVECKLDH 300
>NP_036389
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TMEIKVDH 8
           T+E K+DH
Sbjct: 293 TVECKLDH 300
>NP_078808
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EIKVDH 8
           +IKVDH
Sbjct: 275 QIKVDH 280
>NP_694580
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   MEIKVDH 8
           +E+K+DH
Sbjct: 143 LELKMDH 149
>NP_001106995
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEIKVDHR 9
           M+IK DH+
Sbjct: 544 MDIKNDHK 551
>NP_689828
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEIKVDHR 9
           M+IK DH+
Sbjct: 310 MDIKNDHK 317
>XP_006713581
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEIKVDHR 9
           M+IK DH+
Sbjct: 241 MDIKNDHK 248
>XP_005247218
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEIKVDHR 9
           M+IK DH+
Sbjct: 349 MDIKNDHK 356
>XP_005247217
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEIKVDHR 9
           M+IK DH+
Sbjct: 468 MDIKNDHK 475
>XP_005247216
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEIKVDHR 9
           M+IK DH+
Sbjct: 475 MDIKNDHK 482
>XP_006712810
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EIKVDH 8
           +IKVDH
Sbjct: 275 QIKVDH 280
>XP_006712809
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EIKVDH 8
           +IKVDH
Sbjct: 275 QIKVDH 280
>XP_006712808
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EIKVDH 8
           +IKVDH
Sbjct: 275 QIKVDH 280
>XP_006712807
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EIKVDH 8
           +IKVDH
Sbjct: 126 QIKVDH 131
>NP_006772
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 290 MEVKVD 295
>NP_001273404
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>NP_001273403
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 288 MEVKVD 293
>XP_006726136
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 155 MEVKVD 160
>XP_006726043
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 202 MEVKVD 207
>XP_006726042
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 296 MEVKVD 301
>XP_006726041
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_005275399
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_006726040
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 282 MEVKVD 287
>XP_006726039
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 282 MEVKVD 287
>XP_006726038
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 289 MEVKVD 294
>XP_006726037
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 289 MEVKVD 294
>XP_006726036
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 289 MEVKVD 294
>XP_006726035
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 296 MEVKVD 301
>XP_006725865
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 202 MEVKVD 207
>XP_006725864
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 288 MEVKVD 293
>XP_006725863
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 268 MEVKVD 273
>XP_006725862
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_006725861
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_006725860
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_006725859
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_006725858
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_005275135
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_006725744
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 202 MEVKVD 207
>XP_006725743
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 296 MEVKVD 301
>XP_006725742
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_005274969
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_006725741
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 282 MEVKVD 287
>XP_006725740
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 282 MEVKVD 287
>XP_006725739
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 289 MEVKVD 294
>XP_006725738
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 289 MEVKVD 294
>XP_006725737
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 289 MEVKVD 294
>XP_006725736
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 296 MEVKVD 301
>XP_006725529
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 202 MEVKVD 207
>XP_006715028
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 202 MEVKVD 207
>XP_006715027
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 288 MEVKVD 293
>XP_006715026
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 268 MEVKVD 273
>XP_006715025
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_006715024
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_006715023
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 274 MEVKVD 279
>XP_006715022
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_006715021
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
>XP_005248867
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEIKVD 7
           ME+KVD
Sbjct: 281 MEVKVD 286
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.133    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 537,236
Number of extensions: 931
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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