Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              18    1135
NP_001091680                                                           18    1135
NP_001091679                                                           18    1135
XP_006713048                                                           18    1135
XP_006713047                                                           18    1135
XP_006713046                                                           18    1135
XP_005264943                                                           18    1135
NP_002053                                                              18    1935
XP_006715128                                                           18    1935
XP_006714348                                                           18    1935
XP_006714347                                                           18    1935
NP_001093896                                                           18    1935
NP_001093898                                                           18    1935
NP_066982                                                              18    1935
NP_001093897                                                           18    1935
NP_001093899                                                           18    1935
NP_000155                                                              17    3301
NP_060656                                                              17    4312
NP_005947                                                              17    4312
NP_000151                                                              17    4312
XP_006722340                                                           17    4312
XP_006722339                                                           17    4312
XP_005245374                                                           17    4312
NP_036430                                                              16    5631
NP_001155971                                                           16    5631
NP_060734                                                              16    7355
NP_001030025                                                           15    9605
NP_000319                                                              15    9605
NP_997352                                                              15    9605
NP_663626                                                              15    9605
NP_001091984                                                           15    9605
NP_689672                                                              15    9605
NP_001265539                                                           15    9605
NP_002457                                                              15    9605
NP_569733                                                              15    9605
NP_904324                                                              15    9605
NP_001091079                                                           15    9605
XP_006725313                                                           15    9605
XP_005272690                                                           15    9605
XP_006724601                                                           15    9605
XP_005277990                                                           15    9605
XP_005255200                                                           15    9605
XP_006719745                                                           15    9605
XP_006719744                                                           15    9605
XP_005254044                                                           15    9605
XP_005252861                                                           15    9605
XP_006713065                                                           15    9605
XP_005264953                                                           15    9605
XP_006713064                                                           15    9605
XP_006713063                                                           15    9605
XP_006713062                                                           15    9605
XP_006713061                                                           15    9605
XP_006713060                                                           15    9605
XP_006713059                                                           15    9605
XP_006713058                                                           15    9605
XP_006713057                                                           15    9605
NP_955379                                                              15    9605
>NP_001895
          Length = 781

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 404 TLVQLLGS 411
>NP_001091680
          Length = 781

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 404 TLVQLLGS 411
>NP_001091679
          Length = 781

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 404 TLVQLLGS 411
>XP_006713048
          Length = 720

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 404 TLVQLLGS 411
>XP_006713047
          Length = 774

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 397 TLVQLLGS 404
>XP_006713046
          Length = 774

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 397 TLVQLLGS 404
>XP_005264943
          Length = 781

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           TLVQLLGS
Sbjct: 404 TLVQLLGS 411
>NP_002053
          Length = 463

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TL+ LLG+H
Sbjct: 355 TLIPLLGTH 363
>XP_006715128
          Length = 463

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TL+ LLG+H
Sbjct: 355 TLIPLLGTH 363
>XP_006714348
          Length = 478

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TLVQLLGSH 9
          TLV+LLG H
Sbjct: 55 TLVKLLGIH 63
>XP_006714347
          Length = 527

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TLV+LLG H
Sbjct: 104 TLVKLLGIH 112
>NP_001093896
          Length = 608

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TLV+LLG H
Sbjct: 185 TLVKLLGIH 193
>NP_001093898
          Length = 559

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TLV+LLG H
Sbjct: 136 TLVKLLGIH 144
>NP_066982
          Length = 607

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TLV+LLG H
Sbjct: 185 TLVKLLGIH 193
>NP_001093897
          Length = 607

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TLV+LLG H
Sbjct: 184 TLVKLLGIH 192
>NP_001093899
          Length = 558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLVQLLGSH 9
           TLV+LLG H
Sbjct: 135 TLVKLLGIH 143
>NP_000155
          Length = 466

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TLVQLLGSH 9
           TLV LLG H
Sbjct: 345 TLVPLLGVH 353
>NP_060656
          Length = 853

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TLVQLLGS 8
          T+VQLLG+
Sbjct: 58 TMVQLLGA 65
>NP_005947
          Length = 935

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVQLLGSH 9
           LVQ LG+H
Sbjct: 393 LVQALGAH 400
>NP_000151
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLVQLLGSH 9
           TL+ LLG H
Sbjct: 353 TLIPLLGVH 361
>XP_006722340
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLVQLLGSH 9
           TL+ LLG H
Sbjct: 353 TLIPLLGVH 361
>XP_006722339
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLVQLLGSH 9
           TL+ LLG H
Sbjct: 383 TLIPLLGVH 391
>XP_005245374
          Length = 911

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLVQLLGS 8
           T+VQLLG+
Sbjct: 116 TMVQLLGA 123
>NP_036430
          Length = 1119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TL+Q LGS
Sbjct: 143 TLIQCLGS 150
>NP_001155971
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TL+Q LGS
Sbjct: 236 TLIQCLGS 243
>NP_060734
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLGSH 9
           QL+GSH
Sbjct: 370 QLIGSH 375
>NP_001030025
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLGSH 9
           QLLG+H
Sbjct: 227 QLLGNH 232
>NP_000319
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLGSH 9
           QLLG+H
Sbjct: 227 QLLGNH 232
>NP_997352
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVQLLGSH 9
          L QL+G+H
Sbjct: 67 LPQLIGNH 74
>NP_663626
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LVQLLGS 8
          LVQ+LGS
Sbjct: 85 LVQVLGS 91
>NP_001091984
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LVQLLGS 8
           LVQLLG+
Sbjct: 163 LVQLLGT 169
>NP_689672
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LVQLLGS 8
           LVQLLG+
Sbjct: 163 LVQLLGT 169
>NP_001265539
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLVQLLGSH 9
           +LVQL  SH
Sbjct: 319 SLVQLQASH 327
>NP_002457
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLVQLLGSH 9
           +LVQL  SH
Sbjct: 343 SLVQLQASH 351
>NP_569733
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVQLLGSH 9
           L QLLG H
Sbjct: 801 LSQLLGHH 808
>NP_904324
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVQLLGSH 9
           L QLLG H
Sbjct: 801 LSQLLGHH 808
>NP_001091079
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LVQLLGS 8
          LVQ+LGS
Sbjct: 85 LVQVLGS 91
>XP_006725313
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LVQLLGS 8
          LVQ+LGS
Sbjct: 85 LVQVLGS 91
>XP_005272690
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLGSH 9
           QLLG+H
Sbjct: 227 QLLGNH 232
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLGSH 9
           QLLG+H
Sbjct: 227 QLLGNH 232
>XP_005277990
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LVQLLGS 8
          LVQ+LGS
Sbjct: 85 LVQVLGS 91
>XP_005255200
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LVQLLGS 8
           LVQLLG+
Sbjct: 201 LVQLLGT 207
>XP_006719745
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVQLLGSH 9
           L QLLG H
Sbjct: 801 LSQLLGHH 808
>XP_006719744
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVQLLGSH 9
           L QLLG H
Sbjct: 801 LSQLLGHH 808
>XP_005254044
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVQLLGSH 9
           L QLLG H
Sbjct: 801 LSQLLGHH 808
>XP_005252861
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LVQLLGS 8
          LVQ+LGS
Sbjct: 85 LVQVLGS 91
>XP_006713065
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_005264953
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713064
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713063
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713062
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713061
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713060
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713059
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713058
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>XP_006713057
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
>NP_955379
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLVQLLGS 8
           TLV LLG+
Sbjct: 213 TLVNLLGA 220
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.137    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 438,257
Number of extensions: 648
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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