Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001069                                                              17    3301
NP_001186763                                                           17    3301
NP_542413                                                              17    3301
XP_006717418                                                           16    5631
NP_004000                                                              16    7355
NP_004001                                                              16    7355
NP_003997                                                              16    7355
NP_000100                                                              16    7355
NP_689718                                                              16    7355
XP_006724538                                                           16    7355
XP_006724537                                                           16    7355
XP_006724536                                                           16    7355
XP_006724535                                                           16    7355
XP_006724534                                                           16    7355
XP_006724533                                                           16    7355
XP_006724532                                                           16    7355
XP_006724531                                                           16    7355
XP_006724036                                                           16    7355
XP_006724035                                                           16    7355
XP_006724034                                                           16    7355
XP_006724033                                                           16    7355
XP_006724032                                                           16    7355
XP_006724031                                                           16    7355
XP_005260983                                                           16    7355
XP_006724030                                                           16    7355
>NP_001069
          Length = 739

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TLTVITTRM 9
           TLT+I+T+M
Sbjct: 563 TLTLISTKM 571
>NP_001186763
          Length = 677

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TLTVITTRM 9
           TLT+I+T+M
Sbjct: 501 TLTLISTKM 509
>NP_542413
          Length = 647

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TLTVITTRM 9
           TLT+I+T+M
Sbjct: 471 TLTLISTKM 479
>XP_006717418
          Length = 325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LTVITTRM 9
          L+VITTR+
Sbjct: 40 LSVITTRL 47

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L+VITTR+
Sbjct: 105 LSVITTRL 112
>NP_004000
          Length = 3681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 680 TVTTVTTR 687
>NP_004001
          Length = 3562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 561 TVTTVTTR 568
>NP_003997
          Length = 3685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>NP_000100
          Length = 3677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 676 TVTTVTTR 683
>NP_689718
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
>XP_006724538
          Length = 3575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>XP_006724537
          Length = 3593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>XP_006724536
          Length = 3657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>XP_006724535
          Length = 3660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 641 TVTTVTTR 648
>XP_006724534
          Length = 3668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>XP_006724533
          Length = 3690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>XP_006724532
          Length = 3695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 676 TVTTVTTR 683
>XP_006724531
          Length = 3703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TLTVITTR 8
           T+T +TTR
Sbjct: 684 TVTTVTTR 691
>XP_006724036
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 134 LSIITTKM 141
>XP_006724035
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 134 LSIITTKM 141
>XP_006724034
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
>XP_006724033
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
>XP_006724032
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
>XP_006724031
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
>XP_005260983
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
>XP_006724030
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LTVITTRM 9
           L++ITT+M
Sbjct: 264 LSIITTKM 271
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.129    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 273,534
Number of extensions: 309
Number of successful extensions: 26
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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