Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     869
XP_005262424                                                           19     869
NP_003310                                                              18    1935
NP_597676                                                              18    1935
NP_001243779                                                           18    1935
NP_596869                                                              18    1935
XP_005246888                                                           18    1935
XP_006712788                                                           18    1935
XP_006712787                                                           18    1935
XP_006712786                                                           18    1935
NP_001254479                                                           18    1935
NP_597681                                                              18    1935
NP_001001389                                                           17    2528
NP_001001390                                                           17    2528
NP_000601                                                              17    2528
XP_005253297                                                           17    2528
XP_005253296                                                           17    2528
XP_005253295                                                           17    2528
XP_005253292                                                           17    2528
XP_005253291                                                           17    2528
XP_005253290                                                           17    2528
XP_006718452                                                           17    2528
XP_006718451                                                           17    2528
XP_005253289                                                           17    2528
XP_005253288                                                           17    2528
NP_056021                                                              17    3301
XP_006720504                                                           17    3301
NP_033720                                                              16    5631
NP_001149                                                              16    5631
XP_005257088                                                           16    7355
NP_955353                                                              16    7355
NP_942141                                                              16    7355
NP_001015887                                                           15    9605
NP_689751                                                              15    9605
NP_055880                                                              15    9605
NP_001265596                                                           15    9605
NP_057361                                                              15    9605
NP_899050                                                              15    9605
NP_001265597                                                           15    9605
NP_001265595                                                           15    9605
NP_660337                                                              15    9605
NP_060733                                                              15    9605
XP_006720926                                                           15    9605
XP_006720925                                                           15    9605
XP_006720924                                                           15    9605
XP_006720923                                                           15    9605
XP_005255218                                                           15    9605
XP_005255217                                                           15    9605
XP_005271520                                                           15    9605
XP_005271519                                                           15    9605
XP_005271518                                                           15    9605
XP_006713580                                                           15    9605
XP_006713579                                                           15    9605
XP_006712103                                                           15    9605
XP_006712102                                                           15    9605
XP_005263581                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TLTSSNRVG 9
            TLTSSN VG
Sbjct: 1342 TLTSSNTVG 1350
>XP_005262424
          Length = 2875

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TLTSSNRVG 9
            TLTSSN VG
Sbjct: 1137 TLTSSNTVG 1145
>NP_003310
          Length = 26926

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TLTSSNRVG 9
            T+T+SNR+G
Sbjct: 8979 TVTASNRLG 8987
>NP_597676
          Length = 27051

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TLTSSNRVG 9
            T+T+SNR+G
Sbjct: 9104 TVTASNRLG 9112
>NP_001243779
          Length = 34350

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1     TLTSSNRVG 9
             T+T+SNR+G
Sbjct: 16403 TVTASNRLG 16411
>NP_596869
          Length = 33423

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1     TLTSSNRVG 9
             T+T+SNR+G
Sbjct: 15476 TVTASNRLG 15484
>XP_005246888
          Length = 22663

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TLTSSNRVG 9
            T+T+SNR+G
Sbjct: 4716 TVTASNRLG 4724
>XP_006712788
          Length = 24022

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TLTSSNRVG 9
            T+T+SNR+G
Sbjct: 6075 TVTASNRLG 6083
>XP_006712787
          Length = 33978

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1     TLTSSNRVG 9
             T+T+SNR+G
Sbjct: 16031 TVTASNRLG 16039
>XP_006712786
          Length = 35484

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1     TLTSSNRVG 9
             T+T+SNR+G
Sbjct: 17537 TVTASNRLG 17545
>NP_001254479
          Length = 35991

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1     TLTSSNRVG 9
             T+T+SNR+G
Sbjct: 18044 TVTASNRLG 18052
>NP_597681
          Length = 27118

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TLTSSNRVG 9
            T+T+SNR+G
Sbjct: 9171 TVTASNRLG 9179
>NP_001001389
          Length = 699

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 488 TLTSSNR 494
>NP_001001390
          Length = 493

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 282 TLTSSNR 288
>NP_000601
          Length = 742

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 531 TLTSSNR 537
>XP_005253297
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 324 TLTSSNR 330
>XP_005253296
          Length = 578

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 367 TLTSSNR 373
>XP_005253295
          Length = 580

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 369 TLTSSNR 375
>XP_005253292
          Length = 700

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 489 TLTSSNR 495
>XP_005253291
          Length = 702

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 491 TLTSSNR 497
>XP_005253290
          Length = 703

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 492 TLTSSNR 498
>XP_006718452
          Length = 735

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 524 TLTSSNR 530
>XP_006718451
          Length = 741

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 530 TLTSSNR 536
>XP_005253289
          Length = 742

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 531 TLTSSNR 537
>XP_005253288
          Length = 743

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TLTSSNR 7
           TLTSSNR
Sbjct: 532 TLTSSNR 538
>NP_056021
          Length = 916

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T+T +NRVG
Sbjct: 735 TITYTNRVG 743
>XP_006720504
          Length = 831

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T+T +NRVG
Sbjct: 735 TITYTNRVG 743
>NP_033720
          Length = 756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLTSSNRVG 9
           T+T  NRVG
Sbjct: 690 TVTLGNRVG 698
>NP_001149
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLTSSNRVG 9
           T+T  NRVG
Sbjct: 663 TVTLGNRVG 671
>XP_005257088
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLTSSNRV 8
          TLT +NR+
Sbjct: 79 TLTGNNRI 86
>NP_955353
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLTSSNRV 8
          TLT +NR+
Sbjct: 79 TLTGNNRI 86
>NP_942141
          Length = 316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLTSSNRV 8
          TLT +NR+
Sbjct: 57 TLTGNNRI 64
>NP_001015887
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TLTSSN 6
           TLTSSN
Sbjct: 310 TLTSSN 315
>NP_689751
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TLTSSN 6
           TLTSSN
Sbjct: 309 TLTSSN 314
>NP_055880
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLTSSNRV 8
           T+TSSN V
Sbjct: 673 TVTSSNSV 680
>NP_001265596
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T +SSN++G
Sbjct: 184 THSSSNKIG 192
>NP_057361
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T +SSN++G
Sbjct: 184 THSSSNKIG 192
>NP_899050
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T +SSN++G
Sbjct: 184 THSSSNKIG 192
>NP_001265597
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T +SSN++G
Sbjct: 184 THSSSNKIG 192
>NP_001265595
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLTSSNRVG 9
           T +SSN++G
Sbjct: 184 THSSSNKIG 192
>NP_660337
          Length = 1748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 904 TSSNRV 909
>NP_060733
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLTSSNRVG 9
           ++TS NR G
Sbjct: 645 SITSPNRTG 653
>XP_006720926
          Length = 1383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 905 TSSNRV 910
>XP_006720925
          Length = 1674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 905 TSSNRV 910
>XP_006720924
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 833 TSSNRV 838
>XP_006720923
          Length = 1738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 905 TSSNRV 910
>XP_005255218
          Length = 1750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 904 TSSNRV 909
>XP_005255217
          Length = 1751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSSNRV 8
           TSSNRV
Sbjct: 905 TSSNRV 910
>XP_005271520
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLTSSNRV 8
           T+TSSN V
Sbjct: 485 TVTSSNSV 492
>XP_005271519
          Length = 1833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLTSSNRV 8
           T+TSSN V
Sbjct: 517 TVTSSNSV 524
>XP_005271518
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLTSSNRV 8
           T+TSSN V
Sbjct: 666 TVTSSNSV 673
>XP_006713580
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TLTSSN 6
           TLTSSN
Sbjct: 251 TLTSSN 256
>XP_006713579
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TLTSSN 6
           TLTSSN
Sbjct: 281 TLTSSN 286
>XP_006712103
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLTSSNRVG 9
           ++TS NR G
Sbjct: 385 SITSPNRTG 393
>XP_006712102
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLTSSNRVG 9
           ++TS NR G
Sbjct: 523 SITSPNRTG 531
>XP_005263581
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TLTSSN 6
            TLTSSN
Sbjct: 1185 TLTSSN 1190
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.114    0.285 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 326,077
Number of extensions: 428
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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