Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001159451                                                           18    1482
XP_006717953                                                           18    1482
NP_004295                                                              18    1935
NP_997719                                                              17    4312
NP_002221                                                              16    5631
NP_001895                                                              16    5631
NP_001091680                                                           16    5631
NP_068831                                                              16    5631
NP_001091679                                                           16    5631
NP_001020272                                                           16    5631
NP_001020252                                                           16    5631
NP_001020261                                                           16    5631
NP_002376                                                              16    5631
NP_001020263                                                           16    5631
NP_996772                                                              16    5631
NP_001157463                                                           16    5631
XP_005266756                                                           16    5631
XP_006721941                                                           16    5631
XP_006721940                                                           16    5631
XP_006721939                                                           16    5631
XP_006721938                                                           16    5631
XP_006721937                                                           16    5631
XP_006721936                                                           16    5631
XP_006721935                                                           16    5631
XP_006721934                                                           16    5631
XP_005257370                                                           16    5631
XP_006713048                                                           16    5631
XP_006713047                                                           16    5631
XP_006713046                                                           16    5631
XP_005264943                                                           16    5631
NP_877438                                                              16    5631
NP_001004760                                                           16    5631
NP_001123537                                                           15    9605
NP_004136                                                              15    9605
XP_006722821                                                           15    9605
XP_006722820                                                           15    9605
XP_005259972                                                           15    9605
XP_006722819                                                           15    9605
XP_006722818                                                           15    9605

>NP_001159451
          Length = 1994

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TLSRVLKVG 9
          TLS VLKVG
Sbjct: 59 TLSAVLKVG 67



>XP_006717953
          Length = 2008

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TLSRVLKVG 9
          TLS VLKVG
Sbjct: 59 TLSAVLKVG 67



>NP_004295
          Length = 1620

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLSRVLK G
Sbjct: 122 TLSRVLKGG 130



>NP_997719
          Length = 291

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           +LSRVLKV
Sbjct: 176 SLSRVLKV 183



>NP_002221
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>NP_001895
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 339 TTSRVLKV 346



>NP_001091680
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 339 TTSRVLKV 346



>NP_068831
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>NP_001091679
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 339 TTSRVLKV 346



>NP_001020272
          Length = 304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS++ K+G
Sbjct: 283 TLSKIFKLG 291



>NP_001020252
          Length = 197

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS++ K+G
Sbjct: 176 TLSKIFKLG 184



>NP_001020261
          Length = 171

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS++ K+G
Sbjct: 150 TLSKIFKLG 158



>NP_002376
          Length = 186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS++ K+G
Sbjct: 165 TLSKIFKLG 173



>NP_001020263
          Length = 160

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS++ K+G
Sbjct: 139 TLSKIFKLG 147



>NP_996772
          Length = 889

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSRVLKVG 9
           +SRVL+VG
Sbjct: 874 MSRVLQVG 881



>NP_001157463
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS V++VG
Sbjct: 115 TLSEVVRVG 123



>XP_005266756
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS++ K+G
Sbjct: 272 TLSKIFKLG 280



>XP_006721941
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>XP_006721940
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>XP_006721939
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>XP_006721938
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>XP_006721937
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>XP_006721936
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 330 TTSRVLKV 337



>XP_006721935
          Length = 762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 347 TTSRVLKV 354



>XP_006721934
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 368 TTSRVLKV 375



>XP_005257370
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 368 TTSRVLKV 375



>XP_006713048
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 339 TTSRVLKV 346



>XP_006713047
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 332 TTSRVLKV 339



>XP_006713046
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 332 TTSRVLKV 339



>XP_005264943
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TLSRVLKV 8
           T SRVLKV
Sbjct: 339 TTSRVLKV 346



>NP_877438
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           TLS V++VG
Sbjct: 162 TLSEVVRVG 170



>NP_001004760
          Length = 321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSRVLKVG 9
           T SR++K+G
Sbjct: 146 TNSRIIKIG 154



>NP_001123537
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



>NP_004136
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



>XP_006722821
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



>XP_006722820
          Length = 2140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



>XP_005259972
          Length = 2141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



>XP_006722819
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



>XP_006722818
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSRVLKV 8
           TLS++LKV
Sbjct: 437 TLSQLLKV 444



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.138    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 274,439
Number of extensions: 392
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)