Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_689540                                                              17    3301
XP_006720086                                                           17    3301
XP_006720085                                                           17    3301
XP_006720084                                                           17    3301
NP_055815                                                              16    5631
NP_009202                                                              16    5631
NP_055524                                                              16    5631
NP_001087197                                                           16    5631
NP_001248750                                                           16    5631
NP_001248749                                                           16    5631
NP_001248748                                                           16    5631
NP_001248747                                                           16    5631
NP_001248746                                                           16    5631
NP_061149                                                              16    5631
XP_005253400                                                           16    5631
XP_006719122                                                           16    5631
XP_005253399                                                           16    5631
XP_006719121                                                           16    5631
XP_005249396                                                           16    5631
XP_006715236                                                           16    5631
XP_005249395                                                           16    5631
XP_005249394                                                           16    5631
XP_006715235                                                           16    5631
XP_006715053                                                           16    5631
XP_006715052                                                           16    5631
XP_006715051                                                           16    5631
XP_005248896                                                           16    5631
NP_001009959                                                           16    7355
NP_065762                                                              16    7355
NP_001139669                                                           16    7355
NP_006428                                                              15    9605
NP_665682                                                              15    9605
NP_001188410                                                           15    9605
NP_115912                                                              15    9605
NP_001188411                                                           15    9605
NP_001188409                                                           15    9605
XP_005246325                                                           15    9605
XP_006712295                                                           15    9605
XP_006712294                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLSEEVSQF 9
            TLSEE+SQF
Sbjct: 2035 TLSEEMSQF 2043
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLSEEVSQF 9
            TLSEE+SQF
Sbjct: 2035 TLSEEMSQF 2043
>NP_689540
          Length = 723

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LSEEVSQF 9
           LSEEVS F
Sbjct: 136 LSEEVSHF 143
>XP_006720086
          Length = 703

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LSEEVSQF 9
           LSEEVS F
Sbjct: 136 LSEEVSHF 143
>XP_006720085
          Length = 704

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LSEEVSQF 9
           LSEEVS F
Sbjct: 136 LSEEVSHF 143
>XP_006720084
          Length = 730

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LSEEVSQF 9
           LSEEVS F
Sbjct: 136 LSEEVSHF 143
>NP_055815
          Length = 464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 184 TLTEEETQF 192
>NP_009202
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 183 TLTEEETQF 191
>NP_055524
          Length = 3546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLSEEVSQF 9
            TL+EE S+F
Sbjct: 3460 TLAEEESEF 3468
>NP_001087197
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 392 TVSEQVSQ 399
>NP_001248750
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>NP_001248749
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>NP_001248748
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 341 TVSEQVSQ 348
>NP_001248747
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 346 TVSEQVSQ 353
>NP_001248746
          Length = 511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 387 TVSEQVSQ 394
>NP_061149
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 317 TVSEQVSQ 324
>XP_005253400
          Length = 412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 184 TLTEEETQF 192
>XP_006719122
          Length = 412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 132 TLTEEETQF 140
>XP_005253399
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 143 TLTEEETQF 151
>XP_006719121
          Length = 464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 184 TLTEEETQF 192
>XP_005249396
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 238 TVSEQVSQ 245
>XP_006715236
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>XP_005249395
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>XP_005249394
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 317 TVSEQVSQ 324
>XP_006715235
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLSEEVSQ 8
           T+SE+VSQ
Sbjct: 495 TVSEQVSQ 502
>XP_006715053
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 183 TLTEEETQF 191
>XP_006715052
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 183 TLTEEETQF 191
>XP_006715051
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 183 TLTEEETQF 191
>XP_005248896
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           TL+EE +QF
Sbjct: 183 TLTEEETQF 191
>NP_001009959
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EEVSQF 9
           EEVSQF
Sbjct: 224 EEVSQF 229
>NP_065762
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EEVSQF 9
           EEVSQF
Sbjct: 211 EEVSQF 216
>NP_001139669
          Length = 7081

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    TLSEEVSQF 9
            ++SE++SQ+
Sbjct: 2924 SISEDISQY 2932
>NP_006428
          Length = 1724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TLSEEVS 7
           TLS+EVS
Sbjct: 258 TLSQEVS 264
>NP_665682
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 491 SMSESVSEF 499
>NP_001188410
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 456 SMSESVSEF 464
>NP_115912
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 487 SMSESVSEF 495
>NP_001188411
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 451 SMSESVSEF 459
>NP_001188409
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 512 SMSESVSEF 520
>XP_005246325
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 420 SMSESVSEF 428
>XP_006712295
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 476 SMSESVSEF 484
>XP_006712294
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLSEEVSQF 9
           ++SE VS+F
Sbjct: 481 SMSESVSEF 489
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.115    0.264 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,025
Number of extensions: 843
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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