Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_001979                                                              17    3301
NP_001003803                                                           17    3301
XP_005267596                                                           17    3301
XP_005267595                                                           17    3301
XP_005267594                                                           17    3301
NP_689938                                                              17    4312
NP_001138667                                                           17    4312
NP_001138573                                                           17    4312
NP_001269662                                                           17    4312
NP_001269663                                                           17    4312
XP_006718727                                                           17    4312
NP_009029                                                              16    5631
NP_001826                                                              16    5631
XP_006724391                                                           16    5631
XP_005261338                                                           16    5631
XP_005277858                                                           16    5631
XP_006724390                                                           16    5631
XP_006724389                                                           16    5631
XP_005277857                                                           16    5631
NP_005560                                                              16    7355
NP_057952                                                              16    7355
NP_001026971                                                           16    7355
NP_078988                                                              16    7355
NP_705833                                                              16    7355
XP_005247174                                                           16    7355
NP_002435                                                              15    9605
NP_065080                                                              15    9605
NP_006148                                                              15    9605
NP_963845                                                              15    9605
NP_001275643                                                           15    9605
NP_001275642                                                           15    9605
NP_570899                                                              15    9605
NP_055809                                                              15    9605
NP_001122080                                                           15    9605
NP_001252540                                                           15    9605
NP_001263308                                                           15    9605
NP_057250                                                              15    9605
NP_001005272                                                           15    9605
NP_001263307                                                           15    9605
NP_001103132                                                           15    9605
NP_073605                                                              15    9605
NP_071904                                                              15    9605
NP_001188474                                                           15    9605
XP_005262326                                                           15    9605
XP_005254792                                                           15    9605
XP_005254791                                                           15    9605
XP_006720501                                                           15    9605
XP_005266561                                                           15    9605
XP_005266560                                                           15    9605
XP_005266559                                                           15    9605
XP_006718835                                                           15    9605
XP_005273857                                                           15    9605
XP_006718834                                                           15    9605
XP_005273855                                                           15    9605
XP_006713270                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLRISELEN 9
            TLRISELE+
Sbjct: 2605 TLRISELES 2613
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLRISELEN 9
            TLRISELE+
Sbjct: 2597 TLRISELES 2605
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLRISELEN 9
            TLRISELE+
Sbjct: 2558 TLRISELES 2566
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLRISELEN 9
            TLRISELE+
Sbjct: 2637 TLRISELES 2645
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLRISELEN 9
            TLRISELE+
Sbjct: 2650 TLRISELES 2658
>NP_001979
          Length = 2033

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    TLRISELE 8
            TLRI ELE
Sbjct: 1443 TLRIQELE 1450
>NP_001003803
          Length = 215

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+S+LEN
Sbjct: 143 LRLSQLEN 150
>XP_005267596
          Length = 178

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+S+LEN
Sbjct: 143 LRLSQLEN 150
>XP_005267595
          Length = 200

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+S+LEN
Sbjct: 128 LRLSQLEN 135
>XP_005267594
          Length = 200

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+S+LEN
Sbjct: 128 LRLSQLEN 135
>NP_689938
          Length = 654

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLRISELE 8
           TLR+SEL+
Sbjct: 246 TLRLSELD 253
>NP_001138667
          Length = 691

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLRISELE 8
           TLR+SEL+
Sbjct: 246 TLRLSELD 253
>NP_001138573
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+SELE+
Sbjct: 115 LRVSELES 122
>NP_001269662
          Length = 690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLRISELE 8
           TLR+SEL+
Sbjct: 246 TLRLSELD 253
>NP_001269663
          Length = 557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLRISELE 8
           TLR+SEL+
Sbjct: 112 TLRLSELD 119
>XP_006718727
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+SELE+
Sbjct: 115 LRVSELES 122
>NP_009029
          Length = 1640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1180 TSRVSELED 1188
>NP_001826
          Length = 1583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1180 TSRVSELED 1188
>XP_006724391
          Length = 1567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1201 TSRVSELED 1209
>XP_005261338
          Length = 1570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1201 TSRVSELED 1209
>XP_005277858
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1201 TSRVSELED 1209
>XP_006724390
          Length = 1623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1163 TSRVSELED 1171
>XP_006724389
          Length = 1653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1201 TSRVSELED 1209
>XP_005277857
          Length = 1661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T R+SELE+
Sbjct: 1201 TSRVSELED 1209
>NP_005560
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ E+E+
Sbjct: 214 TLRVEEVED 222
>NP_057952
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ E+E+
Sbjct: 193 TLRVEEVED 201
>NP_001026971
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ E+E+
Sbjct: 193 TLRVEEVED 201
>NP_078988
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRISELEN 9
           LR+ ELEN
Sbjct: 738 LRLLELEN 745
>NP_705833
          Length = 2970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T+ +SE+EN
Sbjct: 1684 TIALSEVEN 1692
>XP_005247174
          Length = 2679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            T+ +SE+EN
Sbjct: 1393 TIALSEVEN 1401
>NP_002435
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLRISELE 8
           T RIS+LE
Sbjct: 425 TARISQLE 432
>NP_065080
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISELEN 9
           ISELEN
Sbjct: 102 ISELEN 107
>NP_006148
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RISELEN 9
           R+S+LEN
Sbjct: 260 RLSQLEN 266
>NP_963845
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RISELEN 9
           R+S+LEN
Sbjct: 260 RLSQLEN 266
>NP_001275643
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RISELEN 9
           R+S+LEN
Sbjct: 203 RLSQLEN 209
>NP_001275642
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RISELEN 9
           R+S+LEN
Sbjct: 288 RLSQLEN 294
>NP_570899
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LRISELE 8
          LRISE+E
Sbjct: 80 LRISEVE 86
>NP_055809
          Length = 1508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ EL++
Sbjct: 496 TLRVHELQS 504
>NP_001122080
          Length = 1514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ EL++
Sbjct: 502 TLRVHELQS 510
>NP_001252540
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ EL++
Sbjct: 496 TLRVHELQS 504
>NP_001263308
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISELEN 9
           ISELEN
Sbjct: 98  ISELEN 103
>NP_057250
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TLRISELE 8
          +LR+SEL+
Sbjct: 13 SLRVSELQ 20
>NP_001005272
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLRISELEN 9
           TLR SE+ N
Sbjct: 285 TLRNSEMRN 293
>NP_001263307
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  ISELEN 9
          ISELEN
Sbjct: 85 ISELEN 90
>NP_001103132
          Length = 4284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TLRISELEN 9
            +LR+ EL+N
Sbjct: 4113 SLRLRELQN 4121
>NP_073605
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TLRISEL 7
           TL+ISEL
Sbjct: 171 TLKISEL 177
>NP_071904
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+SE+E+
Sbjct: 612 LRVSEVES 619
>NP_001188474
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TLRISEL 7
           TL+ISEL
Sbjct: 171 TLKISEL 177
>XP_005262326
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLRISELE 8
           T RIS+LE
Sbjct: 426 TARISQLE 433
>XP_005254792
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TLRISELE 8
          +LR+SEL+
Sbjct: 4  SLRVSELQ 11
>XP_005254791
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TLRISELE 8
          +LR+SEL+
Sbjct: 6  SLRVSELQ 13
>XP_006720501
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLRISELEN 9
           TLR+ EL++
Sbjct: 447 TLRVHELQS 455
>XP_005266561
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+SE+E+
Sbjct: 322 LRVSEVES 329
>XP_005266560
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+SE+E+
Sbjct: 612 LRVSEVES 619
>XP_005266559
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRISELEN 9
           LR+SE+E+
Sbjct: 538 LRVSEVES 545
>XP_006718835
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LRISELE 8
           LRISE+E
Sbjct: 109 LRISEVE 115
>XP_005273857
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LRISELE 8
          LRISE+E
Sbjct: 30 LRISEVE 36
>XP_006718834
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LRISELE 8
           LRISE+E
Sbjct: 102 LRISEVE 108
>XP_005273855
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LRISELE 8
           LRISE+E
Sbjct: 109 LRISEVE 115
>XP_006713270
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISELEN 9
           ISELEN
Sbjct: 159 ISELEN 164
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.127    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,077
Number of extensions: 868
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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