Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_055178                                                              18    1935
NP_001264984                                                           18    1935
XP_005266395                                                           18    1935
NP_001243668                                                           17    2528
NP_001243667                                                           17    2528
NP_001243666                                                           17    2528
NP_076939                                                              17    2528
NP_001243669                                                           17    2528
NP_004710                                                              17    3301
XP_006719755                                                           17    3301
XP_005269287                                                           17    3301
NP_078966                                                              17    4312
XP_006721023                                                           16    5631
XP_006721022                                                           16    5631
XP_005271295                                                           16    5631
NP_112227                                                              16    5631
NP_009107                                                              16    7355
NP_115800                                                              16    7355
NP_872344                                                              16    7355
XP_006721535                                                           16    7355
XP_005271758                                                           16    7355
XP_005271756                                                           16    7355
XP_005271757                                                           16    7355
XP_005271755                                                           16    7355
XP_005271754                                                           16    7355
XP_006711995                                                           16    7355
NP_037450                                                              15    9605
NP_060842                                                              15    9605
NP_001006946                                                           15    9605
NP_000848                                                              15    9605
NP_055674                                                              15    9605
NP_004361                                                              15    9605
NP_079105                                                              15    9605
XP_006721678                                                           15    9605
XP_005256948                                                           15    9605
XP_005256947                                                           15    9605
XP_005256946                                                           15    9605
XP_005256945                                                           15    9605
XP_006715397                                                           15    9605
XP_005271086                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TLLSSVIPR 9
            TLLSSV PR
Sbjct: 1590 TLLSSVTPR 1598
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TLLSSVIPR 9
            TLLSSV PR
Sbjct: 1385 TLLSSVTPR 1393
>NP_055178
          Length = 4579

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    LLSSVIPR 9
            LLSSV+PR
Sbjct: 3217 LLSSVLPR 3224
>NP_001264984
          Length = 4432

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    LLSSVIPR 9
            LLSSV+PR
Sbjct: 3070 LLSSVLPR 3077
>XP_005266395
          Length = 4588

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    LLSSVIPR 9
            LLSSV+PR
Sbjct: 3226 LLSSVLPR 3233
>NP_001243668
          Length = 309

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TLLSSVIP 8
           TLLS+VIP
Sbjct: 263 TLLSAVIP 270
>NP_001243667
          Length = 278

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TLLSSVIP 8
           TLLS+VIP
Sbjct: 232 TLLSAVIP 239
>NP_001243666
          Length = 386

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TLLSSVIP 8
           TLLS+VIP
Sbjct: 340 TLLSAVIP 347
>NP_076939
          Length = 367

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TLLSSVIP 8
           TLLS+VIP
Sbjct: 321 TLLSAVIP 328
>NP_001243669
          Length = 296

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   TLLSSVIP 8
           TLLS+VIP
Sbjct: 250 TLLSAVIP 257
>NP_004710
          Length = 1463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLSSVIPR 9
           L+SSV+PR
Sbjct: 260 LISSVLPR 267
>XP_006719755
          Length = 1418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLSSVIPR 9
           L+SSV+PR
Sbjct: 215 LISSVLPR 222
>XP_005269287
          Length = 1527

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLSSVIPR 9
           L+SSV+PR
Sbjct: 324 LISSVLPR 331
>NP_078966
          Length = 14507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TLLSSVIP 8
           T++SSVIP
Sbjct: 673 TMVSSVIP 680
>XP_006721023
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSSVIPR 9
           LLSS +PR
Sbjct: 555 LLSSFVPR 562
>XP_006721022
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSSVIPR 9
           LLSS +PR
Sbjct: 556 LLSSFVPR 563
>XP_005271295
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSSVIPR 9
           LLS V+PR
Sbjct: 191 LLSQVLPR 198
>NP_112227
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSSVIPR 9
           LLS V+PR
Sbjct: 191 LLSQVLPR 198
>NP_009107
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  TLLSSVI 7
          TLLSSVI
Sbjct: 57 TLLSSVI 63
>NP_115800
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>NP_872344
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSSVIPR 9
           LLS V+PR
Sbjct: 392 LLSVVVPR 399
>XP_006721535
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSSVIPR 9
           LLS V+PR
Sbjct: 196 LLSVVVPR 203
>XP_005271758
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271756
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271757
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271755
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271754
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_006711995
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TLLSSVIPR 9
          TLLS  +PR
Sbjct: 17 TLLSKGVPR 25
>NP_037450
          Length = 2229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SSVIPR 9
          SSVIPR
Sbjct: 37 SSVIPR 42
>NP_060842
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           LLSS++P
Sbjct: 665 LLSSILP 671
>NP_001006946
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           LLSS++P
Sbjct: 129 LLSSILP 135
>NP_000848
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TLLSSVIP 8
           TLL SV+P
Sbjct: 392 TLLYSVLP 399
>NP_055674
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLLSSVIPR 9
           TLL +V+P+
Sbjct: 231 TLLQAVLPQ 239
>NP_004361
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLLSSVIP 8
          TLLS ++P
Sbjct: 79 TLLSELVP 86
>NP_079105
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TLLSSVIP 8
           TLL  VIP
Sbjct: 310 TLLKQVIP 317
>XP_006721678
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLLSSVIPR 9
           TLL +V+P+
Sbjct: 231 TLLQAVLPQ 239
>XP_005256948
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLLSSVIPR 9
           TLL +V+P+
Sbjct: 231 TLLQAVLPQ 239
>XP_005256947
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLLSSVIPR 9
           TLL +V+P+
Sbjct: 231 TLLQAVLPQ 239
>XP_005256946
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLLSSVIPR 9
           TLL +V+P+
Sbjct: 231 TLLQAVLPQ 239
>XP_005256945
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLLSSVIPR 9
           TLL +V+P+
Sbjct: 231 TLLQAVLPQ 239
>XP_006715397
          Length = 2972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLLSSVIP 8
          TLLS ++P
Sbjct: 79 TLLSELVP 86
>XP_005271086
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLSSVIP 8
           LLSS++P
Sbjct: 664 LLSSILP 670
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.135    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 423,180
Number of extensions: 783
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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