Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              19     665
NP_115267                                                              17    3301
NP_061746                                                              17    3301
NP_001171809                                                           16    5631
NP_001098713                                                           16    5631
NP_065817                                                              16    5631
NP_060127                                                              16    5631
XP_005264437                                                           16    5631
NP_982261                                                              16    5631
NP_001002243                                                           16    5631
NP_775885                                                              16    7355
NP_001004060                                                           16    7355
NP_001004067                                                           16    7355
XP_006725258                                                           16    7355
XP_005255375                                                           16    7355
NP_115266                                                              16    7355
NP_055102                                                              16    7355
NP_061745                                                              16    7355
NP_000073                                                              15    9605
NP_004412                                                              15    9605
NP_079150                                                              15    9605
NP_115811                                                              15    9605
NP_001007235                                                           15    9605
NP_001007234                                                           15    9605
NP_000364                                                              15    9605
NP_002410                                                              15    9605
NP_004457                                                              15    9605
NP_236914                                                              15    9605
NP_001074                                                              15    9605
NP_775901                                                              15    9605
NP_937791                                                              15    9605
NP_246273                                                              15    9605
XP_005266736                                                           15    9605
XP_006722498                                                           15    9605
XP_006722497                                                           15    9605
XP_005269585                                                           15    9605
XP_006710974                                                           15    9605
XP_006710973                                                           15    9605
XP_006710972                                                           15    9605
XP_006710971                                                           15    9605
XP_006710970                                                           15    9605
XP_005244790                                                           15    9605
XP_005244789                                                           15    9605
XP_005244788                                                           15    9605
NP_001017415                                                           15    9605
NP_003359                                                              15    9605
NP_001017416                                                           15    9605
>NP_004351
          Length = 882

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           TLKVTDA+A
Sbjct: 395 TLKVTDADA 403
>NP_115267
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKVTDAN 8
           +KVTDAN
Sbjct: 230 IKVTDAN 236
>NP_061746
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKVTDAN 8
           +KVTDAN
Sbjct: 230 IKVTDAN 236
>NP_001171809
          Length = 1148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLKVTDAN 8
           ++KVTD+N
Sbjct: 225 SIKVTDSN 232
>NP_001098713
          Length = 1101

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLKVTDAN 8
           ++KVTD+N
Sbjct: 225 SIKVTDSN 232
>NP_065817
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLKVTDAN 8
           ++KVTD+N
Sbjct: 225 SIKVTDSN 232
>NP_060127
          Length = 909

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           +LKVTDA A
Sbjct: 838 SLKVTDAFA 846
>XP_005264437
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           +LKVTDA A
Sbjct: 866 SLKVTDAFA 874
>NP_982261
          Length = 936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           +LKVTDA A
Sbjct: 866 SLKVTDAFA 874
>NP_001002243
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           +LKVTDA A
Sbjct: 838 SLKVTDAFA 846
>NP_775885
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           T++VT++NA
Sbjct: 198 TVRVTNSNA 206
>NP_001004060
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           T++VT++NA
Sbjct: 198 TVRVTNSNA 206
>NP_001004067
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           T++VT++NA
Sbjct: 198 TVRVTNSNA 206
>XP_006725258
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           T++VT++NA
Sbjct: 198 TVRVTNSNA 206
>XP_005255375
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           T++VT++NA
Sbjct: 198 TVRVTNSNA 206
>NP_115266
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LKVTDAN 8
           ++VTDAN
Sbjct: 227 IRVTDAN 233
>NP_055102
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TLKVTDANA 9
           T++VT++NA
Sbjct: 198 TVRVTNSNA 206
>NP_061745
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LKVTDAN 8
           ++VTDAN
Sbjct: 227 IRVTDAN 233
>NP_000073
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TLKVTDAN 8
           TLKV D N
Sbjct: 123 TLKVWDTN 130
>NP_004412
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKVTDANA 9
           LK+T ANA
Sbjct: 412 LKITIANA 419
>NP_079150
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 764 LKVTDA 769
>NP_115811
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 284 TLKITD 289
>NP_001007235
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TLKVTDAN 8
           TLKV D N
Sbjct: 123 TLKVWDTN 130
>NP_001007234
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TLKVTDAN 8
          TLKV D N
Sbjct: 65 TLKVWDTN 72
>NP_000364
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 144 LKVTDA 149
>NP_002410
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 262 TLKITD 267
>NP_004457
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 515 TLKITD 520
>NP_236914
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 511 TLKITD 516
>NP_001074
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 553 TLKITD 558
>NP_775901
          Length = 2226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LKVTDA 7
            LKVTDA
Sbjct: 1249 LKVTDA 1254
>NP_937791
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 143 TLKITD 148
>NP_246273
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 501 TLKITD 506
>XP_005266736
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 337 LKVTDA 342
>XP_006722498
          Length = 2059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LKVTDA 7
            LKVTDA
Sbjct: 1250 LKVTDA 1255
>XP_006722497
          Length = 2227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LKVTDA 7
            LKVTDA
Sbjct: 1250 LKVTDA 1255
>XP_005269585
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TLKVTD 6
           TLK+TD
Sbjct: 143 TLKITD 148
>XP_006710974
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 406 LKVTDA 411
>XP_006710973
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 406 LKVTDA 411
>XP_006710972
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 764 LKVTDA 769
>XP_006710971
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 764 LKVTDA 769
>XP_006710970
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKVTDA 7
           LKVTDA
Sbjct: 764 LKVTDA 769
>XP_005244790
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKVTDANA 9
           LK+T ANA
Sbjct: 412 LKITIANA 419
>XP_005244789
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKVTDANA 9
           LK+T ANA
Sbjct: 437 LKITIANA 444
>XP_005244788
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKVTDANA 9
           LK+T ANA
Sbjct: 437 LKITIANA 444
>NP_001017415
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           ++KVTD N+
Sbjct: 597 SVKVTDLNS 605
>NP_003359
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           ++KVTD N+
Sbjct: 597 SVKVTDLNS 605
>NP_001017416
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLKVTDANA 9
           ++KVTD N+
Sbjct: 597 SVKVTDLNS 605
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.113    0.277 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 376,235
Number of extensions: 613
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package