Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     390
NP_004561                                                              20     390
NP_001275703                                                           20     390
XP_005253450                                                           20     390
XP_006719151                                                           20     390
NP_005384                                                              18    1482
NP_001156729                                                           18    1482
NP_001089                                                              17    4312
NP_005233                                                              16    5631
NP_006717                                                              16    5631
NP_001186211                                                           16    5631
NP_059984                                                              16    5631
XP_006724893                                                           16    5631
XP_006724892                                                           16    5631
XP_005274762                                                           16    5631
XP_005263434                                                           16    5631
XP_005263433                                                           16    5631
XP_005263432                                                           16    5631
XP_005263431                                                           16    5631
XP_006714492                                                           16    5631
XP_005263430                                                           16    5631
XP_005263429                                                           16    5631
NP_006796                                                              16    5631
NP_001549                                                              16    7355
NP_085097                                                              16    7355
NP_001275748                                                           16    7355
NP_001275749                                                           16    7355
NP_001010986                                                           16    7355
NP_001073003                                                           16    7355
NP_001073001                                                           16    7355
NP_001073002                                                           16    7355
NP_775965                                                              16    7355
XP_006724816                                                           16    7355
XP_006724815                                                           16    7355
XP_006724814                                                           16    7355
XP_005262462                                                           16    7355
XP_006720700                                                           16    7355
XP_006720699                                                           16    7355
XP_006718896                                                           16    7355
NP_002664                                                              15    9605
NP_001123554                                                           15    9605
NP_001035517                                                           15    9605
NP_079455                                                              15    9605
NP_056020                                                              15    9605
NP_001092261                                                           15    9605
NP_067065                                                              15    9605
NP_115565                                                              15    9605
NP_005317                                                              15    9605
NP_078904                                                              15    9605
NP_001182412                                                           15    9605
XP_006720028                                                           15    9605
XP_005268363                                                           15    9605
XP_005268362                                                           15    9605
XP_005268358                                                           15    9605
XP_005268360                                                           15    9605
XP_005268357                                                           15    9605
XP_005268356                                                           15    9605
XP_005252173                                                           15    9605
XP_005273222                                                           15    9605
XP_006711450                                                           15    9605
XP_005273221                                                           15    9605
NP_149040                                                              15    9605
NP_001092260                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLFVGAINI 9
            T+FVGAINI
Sbjct: 1458 TVFVGAINI 1466
>NP_004561
          Length = 1445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLFVGAINI 9
            T+FVGAINI
Sbjct: 1417 TVFVGAINI 1425
>NP_001275703
          Length = 1264

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLFVGAINI 9
            T+FVGAINI
Sbjct: 1236 TVFVGAINI 1244
>XP_005253450
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLFVGAINI 9
            T+FVGAINI
Sbjct: 1458 TVFVGAINI 1466
>XP_006719151
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TLFVGAINI 9
            T+FVGAINI
Sbjct: 1458 TVFVGAINI 1466
>NP_005384
          Length = 1909

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TLFVGAIN 8
          TL+VGA+N
Sbjct: 65 TLYVGAVN 72
>NP_001156729
          Length = 1932

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TLFVGAIN 8
          TL+VGA+N
Sbjct: 88 TLYVGAVN 95
>NP_001089
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LFVGAINI 9
           L +GAINI
Sbjct: 617 LLIGAINI 624
>NP_005233
          Length = 397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLFVGAINI 9
           T+F+ A+NI
Sbjct: 215 TIFIPALNI 223
>NP_006717
          Length = 2863

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>NP_001186211
          Length = 2851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>NP_059984
          Length = 1871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          +FVGA+N
Sbjct: 45 VFVGAVN 51
>XP_006724893
          Length = 1719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          +FVGA+N
Sbjct: 45 VFVGAVN 51
>XP_006724892
          Length = 1841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          +FVGA+N
Sbjct: 45 VFVGAVN 51
>XP_005274762
          Length = 1853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          +FVGA+N
Sbjct: 45 VFVGAVN 51
>XP_005263434
          Length = 1557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>XP_005263433
          Length = 2832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>XP_005263432
          Length = 2852

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>XP_005263431
          Length = 2857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>XP_006714492
          Length = 2867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>XP_005263430
          Length = 2868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>XP_005263429
          Length = 2868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFVGAINI 9
           T F+G +NI
Sbjct: 596 TEFIGTVNI 604
>NP_006796
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LFVGAINI 9
          LF+G +N+
Sbjct: 9  LFIGGLNV 16
>NP_001549
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLFVGAINI 9
           TL VG++N+
Sbjct: 124 TLTVGSVNL 132
>NP_085097
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 426 TVFVGALH 433
>NP_001275748
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 351 TVFVGALH 358
>NP_001275749
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 200 TVFVGALH 207
>NP_001010986
          Length = 1119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG INI
Sbjct: 224 FVGRINI 230
>NP_001073003
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 351 TVFVGALH 358
>NP_001073001
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 356 TVFVGALH 363
>NP_001073002
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 351 TVFVGALH 358
>NP_775965
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG INI
Sbjct: 224 FVGRINI 230
>XP_006724816
          Length = 1105

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG INI
Sbjct: 221 FVGRINI 227
>XP_006724815
          Length = 1105

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG INI
Sbjct: 221 FVGRINI 227
>XP_006724814
          Length = 1116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG INI
Sbjct: 221 FVGRINI 227
>XP_005262462
          Length = 1129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG INI
Sbjct: 221 FVGRINI 227
>XP_006720700
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 431 TVFVGALH 438
>XP_006720699
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFVGAIN 8
           T+FVGA++
Sbjct: 453 TVFVGALH 460
>XP_006718896
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLFVGAINI 9
           TL VG++N+
Sbjct: 104 TLTVGSVNL 112
>NP_002664
          Length = 2135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLFVGAIN 8
          TL++GA N
Sbjct: 46 TLYLGATN 53
>NP_001123554
          Length = 2135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TLFVGAIN 8
          TL++GA N
Sbjct: 46 TLYLGATN 53
>NP_001035517
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLFVGAINI 9
           TL VG++N+
Sbjct: 94  TLQVGSLNV 102
>NP_079455
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          ++VGAIN
Sbjct: 62 VYVGAIN 68
>NP_056020
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>NP_001092261
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  FVGAIN 8
          F+GA+N
Sbjct: 21 FIGAVN 26
>NP_067065
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  FVGAIN 8
          F+GA+N
Sbjct: 21 FIGAVN 26
>NP_115565
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>NP_005317
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TLFVGAINI 9
           TL VG++N+
Sbjct: 142 TLQVGSLNV 150
>NP_078904
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LFVGAINI 9
           +FVG +N+
Sbjct: 375 VFVGQVNV 382
>NP_001182412
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LFVGAINI 9
           +FVG +N+
Sbjct: 375 VFVGQVNV 382
>XP_006720028
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005268363
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005268362
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005268358
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005268360
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005268357
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005268356
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGAINI 9
           FVG IN+
Sbjct: 226 FVGRINV 232
>XP_005252173
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LFVGAI 7
           LFVGAI
Sbjct: 286 LFVGAI 291
>XP_005273222
          Length = 1823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          ++VGAIN
Sbjct: 77 VYVGAIN 83
>XP_006711450
          Length = 1952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          ++VGAIN
Sbjct: 77 VYVGAIN 83
>XP_005273221
          Length = 1974

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LFVGAIN 8
          ++VGAIN
Sbjct: 77 VYVGAIN 83
>NP_149040
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LFVGAI 7
           LFVGAI
Sbjct: 286 LFVGAI 291
>NP_001092260
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  FVGAIN 8
          F+GA+N
Sbjct: 21 FIGAVN 26
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.153    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 341,129
Number of extensions: 582
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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