Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1935
XP_005262424                                                           18    1935
NP_001983                                                              17    3301
NP_001167569                                                           17    4312
NP_060814                                                              17    4312
XP_006717973                                                           17    4312
NP_001121084                                                           16    5631
NP_003032                                                              16    5631
NP_000271                                                              16    5631
NP_001245394                                                           16    5631
NP_001165405                                                           16    5631
NP_001245393                                                           16    5631
NP_001165404                                                           16    5631
NP_071407                                                              16    5631
NP_001245391                                                           16    5631
NP_001245392                                                           16    5631
NP_001595                                                              16    5631
NP_817123                                                              16    5631
XP_006721136                                                           16    5631
XP_006721135                                                           16    5631
XP_005253015                                                           16    5631
XP_006718309                                                           16    5631
XP_006718308                                                           16    5631
XP_006718307                                                           16    5631
XP_005253014                                                           16    5631
XP_005253013                                                           16    5631
XP_005253012                                                           16    5631
XP_005253011                                                           16    5631
XP_006718005                                                           16    5631
XP_006718004                                                           16    5631
XP_006718003                                                           16    5631
XP_005275746                                                           16    5631
XP_003403671                                                           16    5631
XP_006710003                                                           16    5631
NP_001127925                                                           16    5631
NP_004516                                                              16    7355
NP_001277251                                                           16    7355
NP_005500                                                              16    7355
NP_001277250                                                           16    7355
XP_006714623                                                           16    7355
XP_005271970                                                           16    7355
XP_005271969                                                           16    7355
XP_005271967                                                           16    7355
XP_005271966                                                           16    7355
XP_006712591                                                           16    7355
XP_006712590                                                           16    7355
XP_006712589                                                           16    7355
NP_694996                                                              15    9605
NP_001177793                                                           15    9605
NP_055042                                                              15    9605
NP_001265227                                                           15    9605
NP_775922                                                              15    9605
NP_068593                                                              15    9605
XP_006726589                                                           15    9605
XP_006724371                                                           15    9605
XP_006718462                                                           15    9605
XP_006710010                                                           15    9605
>NP_722576
          Length = 3080

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TLFSTSVYT 9
            TLFSTSV T
Sbjct: 1127 TLFSTSVDT 1135
>XP_005262424
          Length = 2875

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TLFSTSVYT 9
           TLFSTSV T
Sbjct: 922 TLFSTSVDT 930
>NP_001983
          Length = 425

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLF  SVYT
Sbjct: 102 TLFVPSVYT 110
>NP_001167569
          Length = 258

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFSTSVY 8
           T+FS+S+Y
Sbjct: 180 TVFSSSIY 187
>NP_060814
          Length = 475

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFSTSVY 8
           T+FS+S+Y
Sbjct: 180 TVFSSSIY 187
>XP_006717973
          Length = 397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TLFSTSVY 8
           T+FS+S+Y
Sbjct: 102 TVFSSSIY 109
>NP_001121084
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_003032
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLF+  +YT
Sbjct: 403 TLFTMDIYT 411
>NP_000271
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_001245394
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_001165405
          Length = 1079

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 274 FSTSVY 279
>NP_001245393
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_001165404
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 274 FSTSVY 279
>NP_071407
          Length = 3354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2514 FSTSVY 2519
>NP_001245391
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 305 FSTSVY 310
>NP_001245392
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 305 FSTSVY 310
>NP_001595
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 305 FSTSVY 310
>NP_817123
          Length = 1040

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LFSTSVYT 9
           +FS SVYT
Sbjct: 156 VFSQSVYT 163
>XP_006721136
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLF+  +YT
Sbjct: 391 TLFTMDIYT 399
>XP_006721135
          Length = 698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLF+  +YT
Sbjct: 403 TLFTMDIYT 411
>XP_005253015
          Length = 286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 155 FSTSVY 160
>XP_006718309
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 224 FSTSVY 229
>XP_006718308
          Length = 369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 238 FSTSVY 243
>XP_006718307
          Length = 377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 246 FSTSVY 251
>XP_005253014
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 305 FSTSVY 310
>XP_005253013
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 291 FSTSVY 296
>XP_005253012
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 291 FSTSVY 296
>XP_005253011
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FSTSVY 8
           FSTSVY
Sbjct: 305 FSTSVY 310
>XP_006718005
          Length = 3397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2557 FSTSVY 2562
>XP_006718004
          Length = 3399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2559 FSTSVY 2564
>XP_006718003
          Length = 3419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2579 FSTSVY 2584
>XP_005275746
          Length = 3352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2512 FSTSVY 2517
>XP_003403671
          Length = 3354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2514 FSTSVY 2519
>XP_006710003
          Length = 3374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    FSTSVY 8
            FSTSVY
Sbjct: 2534 FSTSVY 2539
>NP_001127925
          Length = 1059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LFSTSVYT 9
           +FS SVYT
Sbjct: 156 VFSQSVYT 163
>NP_004516
          Length = 4655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    TLFSTSVY 8
            TLF  SVY
Sbjct: 1649 TLFEDSVY 1656
>NP_001277251
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 771 TLFSEMVYS 779
>NP_005500
          Length = 3027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 944 TLFSEMVYS 952
>NP_001277250
          Length = 3048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 944 TLFSEMVYS 952
>XP_006714623
          Length = 1625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 944 TLFSEMVYS 952
>XP_005271970
          Length = 2931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 944 TLFSEMVYS 952
>XP_005271969
          Length = 3020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 878 TLFSEMVYS 886
>XP_005271967
          Length = 3065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 944 TLFSEMVYS 952
>XP_005271966
          Length = 3086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLFS  VY+
Sbjct: 944 TLFSEMVYS 952
>XP_006712591
          Length = 3308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    TLFSTSVY 8
            TLF  SVY
Sbjct: 1654 TLFEDSVY 1661
>XP_006712590
          Length = 3897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TLFSTSVY 8
           TLF  SVY
Sbjct: 891 TLFEDSVY 898
>XP_006712589
          Length = 4660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    TLFSTSVY 8
            TLF  SVY
Sbjct: 1654 TLFEDSVY 1661
>NP_694996
          Length = 2526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TLFSTSVY 8
           T+FS  VY
Sbjct: 757 TIFSVGVY 764
>NP_001177793
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FSTSVYT 9
          FST+VY+
Sbjct: 22 FSTAVYS 28
>NP_055042
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLF+  +YT
Sbjct: 403 TLFTIDLYT 411
>NP_001265227
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TLFSTSVY 8
           T+FS  VY
Sbjct: 757 TIFSVGVY 764
>NP_775922
          Length = 6996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LFSTSVYT 9
           +FS+ VYT
Sbjct: 570 IFSSPVYT 577
>NP_068593
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FSTSVYT 9
          FST+VY+
Sbjct: 22 FSTAVYS 28
>XP_006726589
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TLFSTS 6
           TLFSTS
Sbjct: 538 TLFSTS 543
>XP_006724371
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TLFSTSVYT 9
           TLF+  +YT
Sbjct: 357 TLFTIDLYT 365
>XP_006718462
          Length = 4966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TLFSTS 6
            TLFSTS
Sbjct: 4573 TLFSTS 4578
>XP_006710010
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TLFSTS 6
           TLFSTS
Sbjct: 710 TLFSTS 715
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.121    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 365,735
Number of extensions: 711
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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