Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
NP_001104268                                                           18    1482
NP_078837                                                              18    1482
XP_005266579                                                           18    1482
XP_006719929                                                           18    1482
NP_001026                                                              16    5631
NP_056057                                                              16    5631
NP_001035207                                                           16    5631
NP_004183                                                              16    5631
NP_001166945                                                           16    5631
NP_001166944                                                           16    5631
NP_001241686                                                           16    5631
NP_001241688                                                           16    5631
NP_001241687                                                           16    5631
NP_006269                                                              16    5631
XP_005274840                                                           16    5631
XP_005274491                                                           16    5631
XP_005271708                                                           16    5631
XP_005271707                                                           16    5631
XP_005271706                                                           16    5631
XP_006718960                                                           16    5631
XP_006718959                                                           16    5631
XP_005251360                                                           16    5631
XP_006711873                                                           16    5631
XP_006711872                                                           16    5631
XP_006711871                                                           16    5631
XP_006711870                                                           16    5631
XP_006711869                                                           16    5631
XP_006711868                                                           16    5631
XP_006711867                                                           16    5631
XP_006711866                                                           16    5631
XP_006711865                                                           16    5631
NP_078869                                                              16    5631
NP_112552                                                              16    7355
NP_112553                                                              16    7355
NP_001155056                                                           16    7355
NP_060216                                                              16    7355
NP_002131                                                              16    7355
NP_001182192                                                           16    7355
NP_079171                                                              16    7355
XP_006718038                                                           16    7355
XP_005270222                                                           16    7355
XP_005252023                                                           16    7355
XP_005252022                                                           16    7355
XP_005252020                                                           16    7355
XP_005252021                                                           16    7355
XP_005252018                                                           16    7355
XP_005252017                                                           16    7355
NP_000221                                                              15    9605
NP_064592                                                              15    9605
NP_001010895                                                           15    9605
NP_001229269                                                           15    9605
NP_776168                                                              15    9605
NP_001124429                                                           15    9605
NP_061841                                                              15    9605
NP_056380                                                              15    9605
NP_056076                                                              15    9605
NP_004757                                                              15    9605
NP_476516                                                              15    9605
NP_001157101                                                           15    9605
XP_005250397                                                           15    9605
XP_005263293                                                           15    9605
XP_006711952                                                           15    9605
XP_006711820                                                           15    9605
XP_005273147                                                           15    9605
XP_006711819                                                           15    9605
NP_115688                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TKTLIKLFY 9
            TKTLIKL Y
Sbjct: 1912 TKTLIKLCY 1920
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TKTLIKLFY 9
            TKTLIKL Y
Sbjct: 1912 TKTLIKLCY 1920
>NP_001104268
          Length = 429

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           T TLI+LFY
Sbjct: 404 TPTLIELFY 412
>NP_078837
          Length = 864

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           T TLI+LFY
Sbjct: 404 TPTLIELFY 412
>XP_005266579
          Length = 653

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           T TLI+LFY
Sbjct: 404 TPTLIELFY 412
>XP_006719929
          Length = 804

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           T TLI+LFY
Sbjct: 344 TPTLIELFY 352
>NP_001026
          Length = 4967

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1821 LIKLFY 1826
>NP_056057
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TKTLIKLF 8
           T+TLI+LF
Sbjct: 353 TETLIELF 360
>NP_001035207
          Length = 1450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TKTLIKLF 8
           T+TLI+LF
Sbjct: 598 TETLIELF 605
>NP_004183
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTLIKLFY 9
           K L+KL+Y
Sbjct: 206 KQLVKLYY 213
>NP_001166945
          Length = 605

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTLIKLFY 9
           K L+KL+Y
Sbjct: 190 KQLVKLYY 197
>NP_001166944
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTLIKLFY 9
           K L+KL+Y
Sbjct: 148 KQLVKLYY 155
>NP_001241686
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 161 SKTTMRLFY 169
>NP_001241688
          Length = 332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 160 SKTTMRLFY 168
>NP_001241687
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 161 SKTTMRLFY 169
>NP_006269
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 157 SKTTMRLFY 165
>XP_005274840
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTLIKLFY 9
           K L+KL+Y
Sbjct: 206 KQLVKLYY 213
>XP_005274491
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KTLIKLFY 9
           K L+KL+Y
Sbjct: 206 KQLVKLYY 213
>XP_005271708
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 157 SKTTMRLFY 165
>XP_005271707
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 161 SKTTMRLFY 169
>XP_005271706
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 180 SKTTMRLFY 188
>XP_006718960
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 182 SKTTMRLFY 190
>XP_006718959
          Length = 356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KT ++LFY
Sbjct: 184 SKTTMRLFY 192
>XP_005251360
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LIKLFY 9
          LIKLFY
Sbjct: 28 LIKLFY 33
>XP_006711873
          Length = 4954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1820 LIKLFY 1825
>XP_006711872
          Length = 2735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1831 LIKLFY 1836
>XP_006711871
          Length = 4906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1831 LIKLFY 1836
>XP_006711870
          Length = 4965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1831 LIKLFY 1836
>XP_006711869
          Length = 4973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1831 LIKLFY 1836
>XP_006711868
          Length = 4975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1821 LIKLFY 1826
>XP_006711867
          Length = 4977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1831 LIKLFY 1836
>XP_006711866
          Length = 4984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1830 LIKLFY 1835
>XP_006711865
          Length = 4985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LIKLFY 9
            LIKLFY
Sbjct: 1831 LIKLFY 1836
>NP_078869
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LIKLFY 9
          LIKLFY
Sbjct: 28 LIKLFY 33
>NP_112552
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 174 TQTTIKLF 181
>NP_112553
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 174 TQTTIKLF 181
>NP_001155056
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TKTLIKLFY 9
           T+TLIK  Y
Sbjct: 502 TETLIKAVY 510
>NP_060216
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TKTLIKLFY 9
           T+TLIK  Y
Sbjct: 499 TETLIKAVY 507
>NP_002131
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 174 TQTTIKLF 181
>NP_001182192
          Length = 1033

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KTL+ LF+
Sbjct: 464 SKTLMNLFF 472
>NP_079171
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KTL+ LF+
Sbjct: 464 SKTLMNLFF 472
>XP_006718038
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KTL+ LF+
Sbjct: 464 SKTLMNLFF 472
>XP_005270222
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKTLIKLFY 9
           +KTL+ LF+
Sbjct: 464 SKTLMNLFF 472
>XP_005252023
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 150 TQTTIKLF 157
>XP_005252022
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 150 TQTTIKLF 157
>XP_005252020
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 150 TQTTIKLF 157
>XP_005252021
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 150 TQTTIKLF 157
>XP_005252018
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 174 TQTTIKLF 181
>XP_005252017
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T+T IKLF
Sbjct: 174 TQTTIKLF 181
>NP_000221
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKTLIK 6
          TKTLIK
Sbjct: 31 TKTLIK 36
>NP_064592
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTLIK 6
           TKTLIK
Sbjct: 383 TKTLIK 388
>NP_001010895
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTLIK 6
           TKTLIK
Sbjct: 383 TKTLIK 388
>NP_001229269
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TKTLIKLFY 9
           TKTL   FY
Sbjct: 496 TKTLTLTFY 504
>NP_776168
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TKTLIKLFY 9
           TKTL   FY
Sbjct: 647 TKTLTLTFY 655
>NP_001124429
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TKTLIKLFY 9
           TKTL   FY
Sbjct: 647 TKTLTLTFY 655
>NP_061841
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TKTLIKLFY 9
          TKT I L Y
Sbjct: 25 TKTTIALLY 33
>NP_056380
          Length = 1812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TKTLIKLFY 9
            TK+L KL Y
Sbjct: 1552 TKSLNKLLY 1560
>NP_056076
          Length = 1498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  TLIKLFY 9
          TL+ LFY
Sbjct: 88 TLVALFY 94
>NP_004757
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TKTLIKLF 8
          T+TL+K F
Sbjct: 46 TQTLVKTF 53
>NP_476516
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T TLI+LF
Sbjct: 404 TPTLIELF 411
>NP_001157101
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LIKLFY 9
           L+KLFY
Sbjct: 824 LLKLFY 829
>XP_005250397
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKTLIK 6
          TKTLIK
Sbjct: 31 TKTLIK 36
>XP_005263293
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTLIKLF 8
           T TLI+LF
Sbjct: 404 TPTLIELF 411
>XP_006711952
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TKTLIKLFY 9
          TKT I L Y
Sbjct: 25 TKTTIALLY 33
>XP_006711820
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TKTLIKLFY 9
           TKTL   FY
Sbjct: 505 TKTLTLTFY 513
>XP_005273147
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TKTLIKLFY 9
           TKTL   FY
Sbjct: 505 TKTLTLTFY 513
>XP_006711819
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TKTLIKLFY 9
           TKTL   FY
Sbjct: 580 TKTLTLTFY 588
>NP_115688
          Length = 244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLIKLF 8
           TLIKLF
Sbjct: 196 TLIKLF 201
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.148    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 397,482
Number of extensions: 695
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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