Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055640                                                              17    3301
NP_001070665                                                           16    5631
NP_001124162                                                           16    5631
NP_001171868                                                           16    5631
NP_653309                                                              16    5631
NP_065960                                                              16    5631
NP_001171866                                                           16    5631
NP_060236                                                              16    5631
NP_001073312                                                           16    5631
NP_001171867                                                           16    5631
XP_006715384                                                           16    5631
XP_006712716                                                           16    5631
XP_005263777                                                           16    5631
XP_005263776                                                           16    5631
XP_006712715                                                           16    5631
XP_006712714                                                           16    5631
XP_006710775                                                           16    5631
XP_005263536                                                           16    5631
NP_001273130                                                           16    7355
NP_079006                                                              16    7355
NP_055937                                                              16    7355
NP_001154829                                                           16    7355
NP_001154831                                                           16    7355
NP_001191676                                                           16    7355
NP_002904                                                              16    7355
NP_001072982                                                           16    7355
NP_001154830                                                           16    7355
NP_001275585                                                           16    7355
XP_006722766                                                           16    7355
XP_006722765                                                           16    7355
XP_006722764                                                           16    7355
XP_005255340                                                           16    7355
XP_005255337                                                           16    7355
XP_005255336                                                           16    7355
XP_005255335                                                           16    7355
XP_005255334                                                           16    7355
XP_006719215                                                           16    7355
NP_002654                                                              15    9605
NP_001230037                                                           15    9605
NP_002244                                                              15    9605
NP_001611                                                              15    9605
NP_940685                                                              15    9605
NP_001257304                                                           15    9605
XP_005256754                                                           15    9605
XP_005256753                                                           15    9605
XP_005256752                                                           15    9605
XP_006721611                                                           15    9605
XP_006721610                                                           15    9605
XP_006718751                                                           15    9605
XP_006718750                                                           15    9605
XP_005274303                                                           15    9605
XP_005274301                                                           15    9605
XP_005274300                                                           15    9605
XP_005274299                                                           15    9605
XP_005274298                                                           15    9605
XP_005274297                                                           15    9605
NP_001094070                                                           15    9605
>NP_055640
          Length = 2271

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT+K RF
Sbjct: 258 TKTQKVRF 265
>NP_001070665
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TKTKKARFS 9
          TKTK  RF+
Sbjct: 51 TKTKDRRFN 59
>NP_001124162
          Length = 789

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KTKKARFS 9
           KTK+ RFS
Sbjct: 328 KTKEIRFS 335
>NP_001171868
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 356 TKTNKARRS 364
>NP_653309
          Length = 1434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KTKKARFS 9
           K K+ARFS
Sbjct: 165 KEKRARFS 172
>NP_065960
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 356 TKTNKARRS 364
>NP_001171866
          Length = 687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 356 TKTNKARRS 364
>NP_060236
          Length = 1166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TKTKKARFS 9
           T +K+ARFS
Sbjct: 229 TLSKRARFS 237
>NP_001073312
          Length = 1759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TKTKKARFS 9
           T +K+ARFS
Sbjct: 229 TLSKRARFS 237
>NP_001171867
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 356 TKTNKARRS 364
>XP_006715384
          Length = 772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KTKKARFS 9
           KTK+ RFS
Sbjct: 311 KTKEIRFS 318
>XP_006712716
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 284 TKTNKARRS 292
>XP_005263777
          Length = 735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 359 TKTNKARRS 367
>XP_005263776
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 359 TKTNKARRS 367
>XP_006712715
          Length = 740

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 356 TKTNKARRS 364
>XP_006712714
          Length = 740

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKTKKARFS 9
           TKT KAR S
Sbjct: 356 TKTNKARRS 364
>XP_006710775
          Length = 1759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TKTKKARFS 9
           T +K+ARFS
Sbjct: 229 TLSKRARFS 237
>XP_005263536
          Length = 1783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TKTKKARFS 9
           T +K+ARFS
Sbjct: 253 TLSKRARFS 261
>NP_001273130
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TKTKKARFS 9
          ++T+KA+FS
Sbjct: 60 SQTQKAKFS 68
>NP_079006
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TKTKKARFS 9
          ++T+KA+FS
Sbjct: 61 SQTQKAKFS 69
>NP_055937
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 166 TKTKKA 171
>NP_001154829
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 166 TKTKKA 171
>NP_001154831
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 116 TKTKKA 121
>NP_001191676
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KTKKAR 7
           KTKKAR
Sbjct: 237 KTKKAR 242
>NP_002904
          Length = 1147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KTKKAR 7
           KTKKAR
Sbjct: 237 KTKKAR 242
>NP_001072982
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>NP_001154830
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 166 TKTKKA 171
>NP_001275585
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>XP_006722766
          Length = 876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 153 TKTKKA 158
>XP_006722765
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 166 TKTKKA 171
>XP_006722764
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TKTKKA 6
           TKTKKA
Sbjct: 166 TKTKKA 171
>XP_005255340
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>XP_005255337
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>XP_005255336
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>XP_005255335
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>XP_005255334
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KTKKARFS 9
           K+KK++FS
Sbjct: 214 KSKKSKFS 221
>XP_006719215
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TKTKKARFS 9
          ++T+KA+FS
Sbjct: 61 SQTQKAKFS 69
>NP_002654
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 566 TKTTKAKY 573
>NP_001230037
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 566 TKTTKAKY 573
>NP_002244
          Length = 1356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KTKKARF 8
           KTK ARF
Sbjct: 939 KTKGARF 945
>NP_001611
          Length = 5890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 3346 KSKKSRF 3352
>NP_940685
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  KTKKARF 8
          KTK ARF
Sbjct: 11 KTKYARF 17
>NP_001257304
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  KTKKARF 8
          KTK ARF
Sbjct: 11 KTKYARF 17
>XP_005256754
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 146 TKTTKAKY 153
>XP_005256753
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 181 TKTTKAKY 188
>XP_005256752
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 566 TKTTKAKY 573
>XP_006721611
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 423 TKTTKAKY 430
>XP_006721610
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TKTKKARF 8
           TKT KA++
Sbjct: 566 TKTTKAKY 573
>XP_006718751
          Length = 3489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTKKARF 8
           K+KK+RF
Sbjct: 945 KSKKSRF 951
>XP_006718750
          Length = 4001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 1457 KSKKSRF 1463
>XP_005274303
          Length = 4506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 1962 KSKKSRF 1968
>XP_005274301
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 3346 KSKKSRF 3352
>XP_005274300
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 3218 KSKKSRF 3224
>XP_005274299
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 3218 KSKKSRF 3224
>XP_005274298
          Length = 5890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 3346 KSKKSRF 3352
>XP_005274297
          Length = 5890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTKKARF 8
            K+KK+RF
Sbjct: 3346 KSKKSRF 3352
>NP_001094070
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  KTKKARF 8
          KTK ARF
Sbjct: 11 KTKYARF 17
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.112    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 382,985
Number of extensions: 528
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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