Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_037397                                                              17    2528
NP_055809                                                              16    5631
NP_001122080                                                           16    5631
NP_659404                                                              16    5631
NP_067585                                                              16    5631
NP_004318                                                              16    5631
NP_001269536                                                           16    5631
NP_036552                                                              16    5631
NP_001121797                                                           16    5631
NP_036577                                                              16    5631
NP_001185950                                                           16    5631
XP_006720502                                                           16    5631
XP_006720501                                                           16    5631
NP_001139669                                                           16    5631
NP_056144                                                              16    7355
NP_001104595                                                           16    7355
XP_006724643                                                           16    7355
XP_006724642                                                           16    7355
XP_006722774                                                           16    7355
XP_005259895                                                           16    7355
XP_005259894                                                           16    7355
NP_112208                                                              16    7355
NP_005004                                                              15    9605
NP_000536                                                              15    9605
NP_002378                                                              15    9605
NP_001078846                                                           15    9605
NP_060611                                                              15    9605
NP_291025                                                              15    9605
NP_149111                                                              15    9605
NP_001258011                                                           15    9605
NP_775808                                                              15    9605
NP_061743                                                              15    9605
NP_114476                                                              15    9605
XP_006725072                                                           15    9605
XP_006725071                                                           15    9605
XP_006725070                                                           15    9605
XP_006721553                                                           15    9605
XP_006721552                                                           15    9605
XP_006721551                                                           15    9605
XP_006721550                                                           15    9605
XP_005256620                                                           15    9605
XP_005253988                                                           15    9605
XP_005274450                                                           15    9605
XP_006718302                                                           15    9605
XP_005253005                                                           15    9605
XP_005253000                                                           15    9605
XP_005253004                                                           15    9605
XP_005253002                                                           15    9605
XP_005253001                                                           15    9605
XP_005252999                                                           15    9605
XP_005252998                                                           15    9605
XP_005277669                                                           15    9605
XP_005277638                                                           15    9605
XP_005277637                                                           15    9605
XP_005277636                                                           15    9605
XP_005249263                                                           15    9605
XP_005272048                                                           15    9605
XP_006714680                                                           15    9605
XP_005248440                                                           15    9605
XP_006714568                                                           15    9605
XP_005248439                                                           15    9605
NP_694958                                                              15    9605
NP_001128130                                                           15    9605
NP_001003795                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            TKLQSV AL
Sbjct: 3127 TKLQSVQAL 3135
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            TKLQSV AL
Sbjct: 3127 TKLQSVQAL 3135
>NP_037397
          Length = 782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TKLQSVHAL 9
           TKL  VHAL
Sbjct: 165 TKLAGVHAL 173
>NP_055809
          Length = 1508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KLQSVHAL 9
            K QSVH+L
Sbjct: 1189 KAQSVHSL 1196
>NP_001122080
          Length = 1514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KLQSVHAL 9
            K QSVH+L
Sbjct: 1195 KAQSVHSL 1202
>NP_659404
          Length = 547

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKLQSVHAL 9
          TK+ S+H+L
Sbjct: 47 TKMVSIHSL 55
>NP_067585
          Length = 1227

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KLQSVHAL 9
           KLQ+VH++
Sbjct: 888 KLQTVHSI 895
>NP_004318
          Length = 1271

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KLQSVHAL 9
           KLQ+VH++
Sbjct: 888 KLQTVHSI 895
>NP_001269536
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKLQSVHAL 9
          TK+ S+H+L
Sbjct: 35 TKMVSIHSL 43
>NP_036552
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KLQSVHA 8
           KLQ VHA
Sbjct: 224 KLQDVHA 230
>NP_001121797
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQSVHAL 9
           LQSVHA+
Sbjct: 117 LQSVHAV 123
>NP_036577
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQSVHAL 9
           LQSVHA+
Sbjct: 117 LQSVHAV 123
>NP_001185950
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LQSVHAL 9
           LQSVHA+
Sbjct: 117 LQSVHAV 123
>XP_006720502
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLQSVHAL 9
           K QSVH+L
Sbjct: 612 KAQSVHSL 619
>XP_006720501
          Length = 1459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KLQSVHAL 9
            K QSVH+L
Sbjct: 1140 KAQSVHSL 1147
>NP_001139669
          Length = 7081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            TKLQS++ L
Sbjct: 6511 TKLQSINKL 6519
>NP_056144
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KLQSVHAL 9
           KLQ VH L
Sbjct: 200 KLQEVHPL 207
>NP_001104595
          Length = 1488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TKLQSVHA 8
            +KLQ++HA
Sbjct: 1262 SKLQALHA 1269
>XP_006724643
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TKLQSVHA 8
            +KLQ++HA
Sbjct: 1057 SKLQALHA 1064
>XP_006724642
          Length = 1520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TKLQSVHA 8
            +KLQ++HA
Sbjct: 1294 SKLQALHA 1301
>XP_006722774
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KLQSVHAL 9
           KLQ VH L
Sbjct: 239 KLQEVHPL 246
>XP_005259895
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KLQSVHAL 9
           KLQ VH L
Sbjct: 211 KLQEVHPL 218
>XP_005259894
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KLQSVHAL 9
           KLQ VH L
Sbjct: 239 KLQEVHPL 246
>NP_112208
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KLQSVHAL 9
          KLQ +HAL
Sbjct: 20 KLQILHAL 27
>NP_005004
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>NP_000536
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLQSVHAL 9
           +LQS HAL
Sbjct: 495 QLQSPHAL 502
>NP_002378
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKLQSVHA 8
           T+LQSV A
Sbjct: 282 TRLQSVQA 289
>NP_001078846
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKLQSVHA 8
           T+LQSV A
Sbjct: 472 TRLQSVQA 479
>NP_060611
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           T LQSVH
Sbjct: 119 TLLQSVH 125
>NP_291025
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KLQSVHAL 9
           +LQS+H +
Sbjct: 428 RLQSIHTM 435
>NP_149111
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>NP_001258011
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>NP_775808
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           TK+ SVH
Sbjct: 856 TKIDSVH 862
>NP_061743
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKLQSVHAL 9
           T+L +VHA+
Sbjct: 259 TRLLTVHAI 267
>NP_114476
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKLQSVHAL 9
           T+L +VHA+
Sbjct: 259 TRLLTVHAI 267
>XP_006725072
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>XP_006725071
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>XP_006725070
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>XP_006721553
          Length = 2286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            ++LQS+H L
Sbjct: 1068 SQLQSMHTL 1076
>XP_006721552
          Length = 2299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            ++LQS+H L
Sbjct: 1068 SQLQSMHTL 1076
>XP_006721551
          Length = 2301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            ++LQS+H L
Sbjct: 1030 SQLQSMHTL 1038
>XP_006721550
          Length = 2326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            ++LQS+H L
Sbjct: 1068 SQLQSMHTL 1076
>XP_005256620
          Length = 2339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TKLQSVHAL 9
            ++LQS+H L
Sbjct: 1068 SQLQSMHTL 1076
>XP_005253988
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLQSVHAL 9
           +LQS HAL
Sbjct: 495 QLQSPHAL 502
>XP_005274450
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KLQSVHAL 9
           +LQS+H +
Sbjct: 428 RLQSIHTM 435
>XP_006718302
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005253005
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005253000
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005253004
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005253002
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005253001
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005252999
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005252998
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  TKLQSVH 7
          TK+Q++H
Sbjct: 32 TKVQNIH 38
>XP_005277669
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           TK+ SVH
Sbjct: 856 TKIDSVH 862
>XP_005277638
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           TK+ SVH
Sbjct: 662 TKIDSVH 668
>XP_005277637
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           TK+ SVH
Sbjct: 785 TKIDSVH 791
>XP_005277636
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           TK+ SVH
Sbjct: 856 TKIDSVH 862
>XP_005249263
          Length = 200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           T LQSVH
Sbjct: 118 TLLQSVH 124
>XP_005272048
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKLQSVHA 8
           T+LQSV A
Sbjct: 282 TRLQSVQA 289
>XP_006714680
          Length = 1002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKLQSVHA 8
           T+LQSV A
Sbjct: 433 TRLQSVQA 440
>XP_005248440
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>XP_006714568
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>XP_005248439
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 KLQSVHA 8
         KLQS HA
Sbjct: 3 KLQSKHA 9
>NP_694958
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KLQSVHAL 9
          K+Q VHA+
Sbjct: 90 KVQDVHAV 97
>NP_001128130
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KLQSVHAL 9
          K+Q VHA+
Sbjct: 91 KVQDVHAV 98
>NP_001003795
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TKLQSVH 7
           TK+ SVH
Sbjct: 856 TKIDSVH 862
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.120    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 501,743
Number of extensions: 683
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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