Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              20     299
NP_001243397                                                           20     299
XP_005269721                                                           20     299
NP_005849                                                              17    4312
XP_006726892                                                           17    4312
XP_006726881                                                           17    4312
XP_006726878                                                           17    4312
XP_003403538                                                           17    4312
XP_006724469                                                           17    4312
XP_006724467                                                           17    4312
XP_006724461                                                           17    4312
XP_005259763                                                           17    4312
XP_006710191                                                           17    4312
NP_115811                                                              16    5631
NP_001456                                                              16    5631
NP_955367                                                              16    5631
NP_036260                                                              16    5631
NP_001230022                                                           16    5631
XP_006714529                                                           16    5631
XP_006714528                                                           16    5631
XP_006714527                                                           16    5631
XP_006710516                                                           16    5631
NP_002449                                                              16    7355
NP_001073936                                                           16    7355
NP_078966                                                              15    9605
NP_003491                                                              15    9605
XP_006726157                                                           15    9605
XP_005275612                                                           15    9605
XP_005275610                                                           15    9605
XP_006726064                                                           15    9605
XP_005275460                                                           15    9605
XP_006715157                                                           15    9605
XP_005249149                                                           15    9605
XP_006713403                                                           15    9605
XP_005265563                                                           15    9605
XP_005265562                                                           15    9605
NP_002254                                                              15    9605



>NP_036462
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TKITTSSTY 9
           TKITT+STY
Sbjct: 411 TKITTTSTY 419





>NP_001243397
          Length = 1890

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TKITTSSTY 9
           TKITT+STY
Sbjct: 411 TKITTTSTY 419





>XP_005269721
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TKITTSSTY 9
           TKITT+STY
Sbjct: 411 TKITTTSTY 419





>NP_005849
          Length = 692

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TKITTSSTY 9
          T +TT +TY
Sbjct: 43 TSVTTGATY 51





>XP_006726892
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 28 TKVTSGSTF 36





>XP_006726881
          Length = 486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 69 TKVTSGSTF 77





>XP_006726878
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 28 TKVTSGSTF 36





>XP_003403538
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 28 TKVTSGSTF 36





>XP_006724469
          Length = 2373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 28 TKVTSGSTF 36





>XP_006724467
          Length = 450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 33 TKVTSGSTF 41





>XP_006724461
          Length = 430

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 28 TKVTSGSTF 36





>XP_005259763
          Length = 679

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TKITTSSTY 9
          T +TT +TY
Sbjct: 30 TSVTTGATY 38





>XP_006710191
          Length = 1582

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TKITTSSTY 9
          TK+T+ ST+
Sbjct: 28 TKVTSGSTF 36





>NP_115811
          Length = 1036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TKITTSSTY 9
           TK++T+ TY
Sbjct: 300 TKMSTAGTY 308





>NP_001456
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKITTSST 8
           TK+TTS T
Sbjct: 757 TKVTTSIT 764





>NP_955367
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKITTSST 8
           TK+TTS T
Sbjct: 711 TKVTTSIT 718





>NP_036260
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ITTSSTY 9
          +TT+STY
Sbjct: 56 VTTASTY 62





>NP_001230022
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKITTSST 8
           TK+TTS T
Sbjct: 767 TKVTTSIT 774





>XP_006714529
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKITTSST 8
           TK+TTS T
Sbjct: 757 TKVTTSIT 764





>XP_006714528
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKITTSST 8
           TK+TTS T
Sbjct: 757 TKVTTSIT 764





>XP_006714527
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TKITTSST 8
           TK+TTS T
Sbjct: 757 TKVTTSIT 764





>XP_006710516
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ITTSSTY 9
          +TT+STY
Sbjct: 56 VTTASTY 62





>NP_002449
          Length = 5762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TKITTSST 8
            TK+TT++T
Sbjct: 3694 TKLTTTAT 3701





>NP_001073936
          Length = 1848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ITTSSTY 9
           +TTS TY
Sbjct: 382 VTTSETY 388





>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KITTSSTY 9
            K+T SST+
Sbjct: 1164 KVTMSSTF 1171






 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TKITTSSTY 9
            TKI   STY
Sbjct: 6939 TKIKRESTY 6947





>NP_003491
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TKITTSSTY 9
           TK++ S TY
Sbjct: 428 TKLSASCTY 436





>XP_006726157
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





>XP_005275612
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 19 TKITTS 24





>XP_005275610
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





>XP_006726064
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





>XP_005275460
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





>XP_006715157
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





>XP_005249149
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





>XP_006713403
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TKITTSSTY 9
           TK++ S TY
Sbjct: 330 TKLSASCTY 338





>XP_005265563
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TKITTSSTY 9
           TK++ S TY
Sbjct: 358 TKLSASCTY 366





>XP_005265562
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TKITTSSTY 9
           TK++ S TY
Sbjct: 428 TKLSASCTY 436





>NP_002254
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TKITTS 6
          TKITTS
Sbjct: 60 TKITTS 65





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.101    0.241 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 281,894
Number of extensions: 329
Number of successful extensions: 38
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package