Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
XP_005248296                                                           18    1482
XP_005248295                                                           18    1482
NP_009208                                                              18    1482
NP_001277131                                                           18    1935
NP_849191                                                              18    1935
NP_001092105                                                           18    1935
NP_001005738                                                           16    5631
NP_001453                                                              16    5631
XP_006723183                                                           16    5631
NP_115946                                                              16    7355
NP_006435                                                              16    7355
NP_001036016                                                           16    7355
NP_001035529                                                           16    7355
NP_055948                                                              16    7355
NP_001252531                                                           16    7355
NP_001277254                                                           16    7355
NP_001036015                                                           16    7355
NP_689801                                                              16    7355
XP_006720932                                                           16    7355
XP_005255247                                                           16    7355
XP_006720931                                                           16    7355
XP_005255245                                                           16    7355
XP_005255244                                                           16    7355
XP_005268737                                                           16    7355
XP_006716996                                                           16    7355
XP_006726882                                                           15    9605
XP_005276751                                                           15    9605
XP_006726877                                                           15    9605
XP_006726876                                                           15    9605
XP_006726875                                                           15    9605
XP_006726874                                                           15    9605
XP_006726873                                                           15    9605
XP_006724161                                                           15    9605
XP_006724160                                                           15    9605
XP_006724157                                                           15    9605
XP_006724156                                                           15    9605
XP_006724155                                                           15    9605
XP_006724154                                                           15    9605
XP_006724153                                                           15    9605
XP_006710177                                                           15    9605
XP_006710176                                                           15    9605
XP_006710175                                                           15    9605
XP_006710174                                                           15    9605
XP_006710173                                                           15    9605
NP_690867                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TILTRTITT 9
            TILTRTI T
Sbjct: 2066 TILTRTIPT 2074
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TILTRTITT 9
            TILTRTI T
Sbjct: 1861 TILTRTIPT 1869
>XP_005248296
          Length = 630

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           TIL RT+TT
Sbjct: 250 TILERTVTT 258
>XP_005248295
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           TIL RT+TT
Sbjct: 250 TILERTVTT 258
>NP_009208
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           TIL RT+TT
Sbjct: 250 TILERTVTT 258
>NP_001277131
          Length = 869

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           TI+T TITT
Sbjct: 104 TIITTTITT 112
>NP_849191
          Length = 994

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           TI+T TITT
Sbjct: 229 TIITTTITT 237
>NP_001092105
          Length = 993

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           TI+T TITT
Sbjct: 229 TIITTTITT 237
>NP_001005738
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LTRTITT 9
          +TRT+TT
Sbjct: 55 MTRTVTT 61
>NP_001453
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LTRTITT 9
          +TRT+TT
Sbjct: 55 MTRTVTT 61
>XP_006723183
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LTRTITT 9
          +TRT+TT
Sbjct: 55 MTRTVTT 61
>NP_115946
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           T+L R++TT
Sbjct: 250 TVLIRSLTT 258
>NP_006435
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILTRTIT 8
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_001036016
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILTRTIT 8
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_001035529
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 769 ILTSTLTT 776
>NP_055948
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 775 ILTSTLTT 782
>NP_001252531
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILTRTIT 8
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_001277254
          Length = 1004

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TILTRTITT 9
           T+L R++TT
Sbjct: 250 TVLIRSLTT 258
>NP_001036015
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILTRTIT 8
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_689801
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILTRTIT 8
           ++LTRT+T
Sbjct: 265 SLLTRTLT 272
>XP_006720932
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 522 ILTSTLTT 529
>XP_005255247
          Length = 1322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 761 ILTSTLTT 768
>XP_006720931
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 767 ILTSTLTT 774
>XP_005255245
          Length = 1331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 770 ILTSTLTT 777
>XP_005255244
          Length = 1337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILTRTITT 9
           ILT T+TT
Sbjct: 776 ILTSTLTT 783
>XP_005268737
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILTRTIT 8
           ++LTRT+T
Sbjct: 148 SLLTRTLT 155
>XP_006716996
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILTRTIT 8
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>XP_006726882
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_005276751
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726877
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726876
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726875
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726874
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726873
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724161
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724160
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724157
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724156
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724155
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724154
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724153
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006710177
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710176
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710175
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710174
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710173
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TILTRTI 7
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>NP_690867
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TRTITT 9
           TRT+TT
Sbjct: 379 TRTVTT 384
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.128    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 309,669
Number of extensions: 440
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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