Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           18    1135
NP_004561                                                              18    1135
NP_001275703                                                           18    1135
XP_005253450                                                           18    1135
XP_006719151                                                           18    1135
NP_001005191                                                           16    5631
XP_005250166                                                           16    7355
NP_660207                                                              15    9605
NP_005637                                                              15    9605
NP_444282                                                              15    9605
NP_001005161                                                           15    9605
NP_001171661                                                           15    9605
NP_004245                                                              15    9605
NP_001171665                                                           15    9605
NP_001171662                                                           15    9605
NP_056053                                                              15    9605
NP_001273700                                                           15    9605
NP_001183959                                                           15    9605
NP_115593                                                              15    9605
NP_078944                                                              15    9605
NP_942592                                                              15    9605
NP_060448                                                              15    9605
NP_060217                                                              15    9605
NP_065741                                                              15    9605
NP_001155134                                                           15    9605
NP_001155133                                                           15    9605
XP_005273812                                                           15    9605
XP_005269600                                                           15    9605
XP_006714899                                                           15    9605
XP_005265910                                                           15    9605
XP_006714898                                                           15    9605
XP_005265909                                                           15    9605
XP_005265908                                                           15    9605
XP_005265907                                                           15    9605
XP_005265730                                                           15    9605
XP_005265729                                                           15    9605
XP_005265728                                                           15    9605
XP_005265724                                                           15    9605
XP_006711875                                                           15    9605
XP_005273291                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TILRRLTFS 9
           TILRR TFS
Sbjct: 752 TILRRWTFS 760
>NP_004561
          Length = 1445

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TILRRLTFS 9
           TILRR TFS
Sbjct: 711 TILRRWTFS 719
>NP_001275703
          Length = 1264

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TILRRLTFS 9
           TILRR TFS
Sbjct: 530 TILRRWTFS 538
>XP_005253450
          Length = 1486

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TILRRLTFS 9
           TILRR TFS
Sbjct: 752 TILRRWTFS 760
>XP_006719151
          Length = 1486

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TILRRLTFS 9
           TILRR TFS
Sbjct: 752 TILRRWTFS 760
>NP_001005191
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ILRRLTFS 9
           +++RLTFS
Sbjct: 162 LMKRLTFS 169
>XP_005250166
          Length = 127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RRLTFS 9
           RRLTFS
Sbjct: 112 RRLTFS 117
>NP_660207
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TIL  +TFS
Sbjct: 205 TILMAITFS 213
>NP_005637
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           ILRRLT +
Sbjct: 733 ILRRLTMN 740
>NP_444282
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +LRRL+F
Sbjct: 559 VLRRLSF 565
>NP_001005161
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +L+RLTF
Sbjct: 164 LLKRLTF 170
>NP_001171661
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +LRR+TF
Sbjct: 322 MLRRMTF 328
>NP_004245
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +LRR+TF
Sbjct: 322 MLRRMTF 328
>NP_001171665
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +LRR+TF
Sbjct: 199 MLRRMTF 205
>NP_001171662
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +LRR+TF
Sbjct: 231 MLRRMTF 237
>NP_056053
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 923 TIIRSKTFS 931
>NP_001273700
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ILRRLTFS 9
          +LRRLT S
Sbjct: 87 VLRRLTSS 94
>NP_001183959
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 171 VLRRLTSS 178
>NP_115593
          Length = 2603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 200 VLRRLTSS 207
>NP_078944
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 171 VLRRLTSS 178
>NP_942592
          Length = 2352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 200 VLRRLTSS 207
>NP_060448
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 160 VLRRLTSS 167
>NP_060217
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 171 VLRRLTSS 178
>NP_065741
          Length = 2617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 171 VLRRLTSS 178
>NP_001155134
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 923 TIIRSKTFS 931
>NP_001155133
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 923 TIIRSKTFS 931
>XP_005273812
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILRRLTF 8
           +LRRL+F
Sbjct: 428 VLRRLSF 434
>XP_005269600
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TIL  +TFS
Sbjct: 212 TILMAITFS 220
>XP_006714899
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 685 TIIRSKTFS 693
>XP_005265910
          Length = 1112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 923 TIIRSKTFS 931
>XP_006714898
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 928 TIIRSKTFS 936
>XP_005265909
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 928 TIIRSKTFS 936
>XP_005265908
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 928 TIIRSKTFS 936
>XP_005265907
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILRRLTFS 9
           TI+R  TFS
Sbjct: 928 TIIRSKTFS 936
>XP_005265730
          Length = 1480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 200 VLRRLTSS 207
>XP_005265729
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 200 VLRRLTSS 207
>XP_005265728
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 200 VLRRLTSS 207
>XP_005265724
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           +LRRLT S
Sbjct: 200 VLRRLTSS 207
>XP_006711875
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           ILRRLT +
Sbjct: 277 ILRRLTMN 284
>XP_005273291
          Length = 1620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILRRLTFS 9
           ILRRLT +
Sbjct: 732 ILRRLTMN 739
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.148    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 422,168
Number of extensions: 633
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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