Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     390
XP_006714104                                                           20     390
XP_005265800                                                           20     390
XP_006714103                                                           20     390
XP_006714102                                                           20     390
NP_115984                                                              17    4312
NP_001034795                                                           17    4312
NP_001153610                                                           17    4312
XP_006716194                                                           17    4312
XP_005250657                                                           17    4312
XP_005250656                                                           17    4312
XP_006716193                                                           17    4312
XP_006716192                                                           17    4312
XP_005250655                                                           17    4312
XP_005250654                                                           17    4312
XP_005250653                                                           17    4312
NP_001229725                                                           16    5631
NP_001229724                                                           16    5631
NP_055484                                                              16    5631
XP_005256320                                                           16    5631
NP_001274370                                                           16    7355
NP_955352                                                              16    7355
NP_079176                                                              16    7355
NP_001274371                                                           16    7355
NP_001274368                                                           16    7355
NP_001274372                                                           16    7355
NP_001274366                                                           16    7355
NP_001274369                                                           16    7355
NP_000740                                                              16    7355
NP_001273336                                                           16    7355
NP_689473                                                              16    7355
XP_005263289                                                           16    7355
XP_006714373                                                           16    7355
XP_005263286                                                           16    7355
NP_006693                                                              15    9605
NP_001159583                                                           15    9605
NP_001159585                                                           15    9605
NP_001159586                                                           15    9605
NP_001159584                                                           15    9605
NP_005112                                                              15    9605
NP_077014                                                              15    9605
NP_003250                                                              15    9605
XP_005262372                                                           15    9605
XP_005262371                                                           15    9605
XP_005255628                                                           15    9605
XP_005255627                                                           15    9605
NP_001013716                                                           15    9605
>NP_006197
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TILAQNEDA 9
           TI+AQNEDA
Sbjct: 393 TIVAQNEDA 401
>XP_006714104
          Length = 832

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TILAQNEDA 9
           TI+AQNEDA
Sbjct: 418 TIVAQNEDA 426
>XP_005265800
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TILAQNEDA 9
           TI+AQNEDA
Sbjct: 393 TIVAQNEDA 401
>XP_006714103
          Length = 1111

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TILAQNEDA 9
           TI+AQNEDA
Sbjct: 415 TIVAQNEDA 423
>XP_006714102
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TILAQNEDA 9
           TI+AQNEDA
Sbjct: 418 TIVAQNEDA 426
>NP_115984
          Length = 817

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LAQNEDA 9
           LA+NEDA
Sbjct: 650 LAENEDA 656
>NP_001034795
          Length = 941

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>NP_001153610
          Length = 923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 299 TIIAQNPEA 307
>XP_006716194
          Length = 553

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>XP_005250657
          Length = 553

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>XP_005250656
          Length = 636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>XP_006716193
          Length = 752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 128 TIIAQNPEA 136
>XP_006716192
          Length = 794

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 170 TIIAQNPEA 178
>XP_005250655
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>XP_005250654
          Length = 895

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>XP_005250653
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TILAQNEDA 9
           TI+AQN +A
Sbjct: 317 TIIAQNPEA 325
>NP_001229725
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TILAQNEDA 9
          T+LA  EDA
Sbjct: 24 TLLASGEDA 32
>NP_001229724
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TILAQNEDA 9
          T+LA  EDA
Sbjct: 24 TLLASGEDA 32
>NP_055484
          Length = 819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILAQNEDA 9
           T+LA  EDA
Sbjct: 147 TLLASGEDA 155
>XP_005256320
          Length = 819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TILAQNEDA 9
           T+LA  EDA
Sbjct: 147 TLLASGEDA 155
>NP_001274370
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_955352
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_079176
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_001274371
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_001274368
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_001274372
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_001274366
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 339 TILAENDE 346
>NP_001274369
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>NP_000740
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LAQNEDA 9
          +A+NEDA
Sbjct: 25 IAENEDA 31
>NP_001273336
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILAQNED 8
           +LA+NED
Sbjct: 164 LLAENED 170
>NP_689473
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ILAQNED 8
           +LA+NED
Sbjct: 225 LLAENED 231
>XP_005263289
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 351 TILAENDE 358
>XP_006714373
          Length = 857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 366 TILAENDE 373
>XP_005263286
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           TILA+N++
Sbjct: 378 TILAENDE 385
>NP_006693
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAQNEDA 9
           LAQ EDA
Sbjct: 794 LAQQEDA 800
>NP_001159583
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAQNEDA 9
           LAQ EDA
Sbjct: 842 LAQQEDA 848
>NP_001159585
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAQNEDA 9
           LAQ EDA
Sbjct: 794 LAQQEDA 800
>NP_001159586
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAQNEDA 9
           LAQ EDA
Sbjct: 832 LAQQEDA 838
>NP_001159584
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LAQNEDA 9
           LAQ EDA
Sbjct: 767 LAQQEDA 773
>NP_005112
          Length = 2174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TILAQNEDA 9
           T+L+  EDA
Sbjct: 736 TVLSHEEDA 744
>NP_077014
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ILAQNED 8
           ILAQ ED
Sbjct: 148 ILAQEED 154
>NP_003250
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TILAQNED 8
           T+LA+ ED
Sbjct: 184 TVLARRED 191
>XP_005262372
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LAQNEDA 9
          L+QNED+
Sbjct: 21 LSQNEDS 27
>XP_005262371
          Length = 1107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LAQNEDA 9
           L+QNED+
Sbjct: 101 LSQNEDS 107
>XP_005255628
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ILAQNED 8
           ILAQ ED
Sbjct: 148 ILAQEED 154
>XP_005255627
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ILAQNED 8
           ILAQ ED
Sbjct: 148 ILAQEED 154
>NP_001013716
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TILAQNED 8
           T+L++NE+
Sbjct: 197 TVLSENEE 204
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.118    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 573,557
Number of extensions: 944
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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