Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_001263627                                                           19     665
NP_001263628                                                           19     665
NP_001263626                                                           19     665
NP_055325                                                              17    4312
NP_149015                                                              17    4312
XP_006715989                                                           17    4312
NP_004938                                                              16    7355
NP_680481                                                              16    7355
NP_680480                                                              16    7355
NP_001013649                                                           16    7355
XP_006724707                                                           16    7355
XP_005261505                                                           16    7355
XP_006724260                                                           16    7355
XP_005261504                                                           16    7355
XP_006713073                                                           16    7355
XP_005264975                                                           16    7355
XP_006713072                                                           16    7355
XP_006713071                                                           16    7355
XP_005264974                                                           16    7355
XP_005264973                                                           16    7355
XP_005264972                                                           16    7355
XP_005264971                                                           16    7355
NP_055152                                                              16    7355
NP_005583                                                              15    9605
NP_001159752                                                           15    9605
NP_001159753                                                           15    9605
NP_002935                                                              15    9605
NP_001020750                                                           15    9605
NP_001438                                                              15    9605
NP_742013                                                              15    9605
NP_036560                                                              15    9605
NP_067076                                                              15    9605
NP_001154835                                                           15    9605
NP_001186048                                                           15    9605
NP_110435                                                              15    9605
XP_006722562                                                           15    9605
XP_006722561                                                           15    9605
XP_006722560                                                           15    9605
XP_006722559                                                           15    9605
XP_005266781                                                           15    9605
XP_006722558                                                           15    9605
XP_005266780                                                           15    9605
XP_005266779                                                           15    9605
XP_006721644                                                           15    9605
XP_005256863                                                           15    9605
XP_006721643                                                           15    9605
XP_005254361                                                           15    9605
XP_005252053                                                           15    9605
XP_005252052                                                           15    9605
XP_005252051                                                           15    9605
XP_006715611                                                           15    9605
XP_006714824                                                           15    9605
NP_060651                                                              15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 253 TIITLEDSS 261
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 214 TIITLEDSS 222
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 253 TIITLEDSS 261
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 253 TIITLEDSS 261
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 214 TIITLEDSS 222
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 214 TIITLEDSS 222
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 214 TIITLEDSS 222
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 253 TIITLEDSS 261
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 214 TIITLEDSS 222
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 121 TIITLEDSS 129
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 121 TIITLEDSS 129
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 121 TIITLEDSS 129
>NP_001263627
          Length = 182

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 94  TIITLEDSS 102
>NP_001263628
          Length = 187

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 94  TIITLEDSS 102
>NP_001263626
          Length = 234

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIITLEDST 9
           TIITLEDS+
Sbjct: 94  TIITLEDSS 102
>NP_055325
          Length = 4935

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    TIITLEDST 9
            T++T+++ST
Sbjct: 2908 TVVTMDEST 2916
>NP_149015
          Length = 5142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    TIITLEDST 9
            T++T+++ST
Sbjct: 2908 TVVTMDEST 2916
>XP_006715989
          Length = 5148

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    TIITLEDST 9
            T++T+++ST
Sbjct: 2908 TVVTMDEST 2916
>NP_004938
          Length = 2030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>NP_680481
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEDST 9
           IITL+D T
Sbjct: 155 IITLQDPT 162
>NP_680480
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEDST 9
           IITL+D T
Sbjct: 155 IITLQDPT 162
>NP_001013649
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IITLEDST 9
            IITLE+ T
Sbjct: 1036 IITLEEDT 1043
>XP_006724707
          Length = 1337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IITLEDST 9
            IITLE+ T
Sbjct: 1148 IITLEEDT 1155
>XP_005261505
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEDST 9
           IITL+D T
Sbjct: 155 IITLQDPT 162
>XP_006724260
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEDST 9
           IITL+D T
Sbjct: 155 IITLQDPT 162
>XP_005261504
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEDST 9
           IITL+D T
Sbjct: 155 IITLQDPT 162
>XP_006713073
          Length = 1869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_005264975
          Length = 2022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_006713072
          Length = 2042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_006713071
          Length = 2050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_005264974
          Length = 2057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_005264973
          Length = 2062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_005264972
          Length = 2065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>XP_005264971
          Length = 2071

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TIITLEDS 8
          T++ LEDS
Sbjct: 77 TVVPLEDS 84
>NP_055152
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IITLEDST 9
           IITL+D T
Sbjct: 155 IITLQDPT 162
>NP_005583
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TIITLEDS 8
          TI+++EDS
Sbjct: 85 TILSVEDS 92
>NP_001159752
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TIITLEDS 8
          TI+++EDS
Sbjct: 85 TILSVEDS 92
>NP_001159753
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TIITLEDS 8
          TI+++EDS
Sbjct: 85 TILSVEDS 92
>NP_002935
          Length = 2347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IITLEDST 9
            IIT +DST
Sbjct: 1398 IITAKDST 1405
>NP_001020750
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIITLED 7
           TI++LED
Sbjct: 132 TIVSLED 138
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IITLED 7
           IITLED
Sbjct: 912 IITLED 917
>NP_742013
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TIITLEDST 9
           T++ L+D+T
Sbjct: 139 TVVPLDDAT 147
>NP_036560
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIITLEDS 8
           T +TLEDS
Sbjct: 104 TRLTLEDS 111
>NP_067076
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TIITLEDST 9
           T++ L+D+T
Sbjct: 139 TVVPLDDAT 147
>NP_001154835
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIITLEDS 8
           T +TLEDS
Sbjct: 104 TRLTLEDS 111
>NP_001186048
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TIITLEDST 9
           T++ L+D+T
Sbjct: 139 TVVPLDDAT 147
>NP_110435
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIITLED 7
           TI++LED
Sbjct: 132 TIVSLED 138
>XP_006722562
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_006722561
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_006722560
          Length = 1295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_006722559
          Length = 1297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_005266781
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_006722558
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_005266780
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_005266779
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
>XP_006721644
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIITLED 7
           TI++LED
Sbjct: 132 TIVSLED 138
>XP_005256863
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIITLED 7
           TI++LED
Sbjct: 132 TIVSLED 138
>XP_006721643
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIITLED 7
           TI++LED
Sbjct: 132 TIVSLED 138
>XP_005254361
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIITLEDS 8
           T +TLEDS
Sbjct: 104 TRLTLEDS 111
>XP_005252053
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TIITLEDS 8
          TI+++EDS
Sbjct: 85 TILSVEDS 92
>XP_005252052
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TIITLEDS 8
          TI+++EDS
Sbjct: 85 TILSVEDS 92
>XP_005252051
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TIITLEDS 8
          TI+++EDS
Sbjct: 85 TILSVEDS 92
>XP_006715611
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IITLEDST 9
            IIT +DST
Sbjct: 1393 IITAKDST 1400
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IITLED 7
           IITLED
Sbjct: 912 IITLED 917
>NP_060651
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITLEDST 9
           +TL+DST
Sbjct: 119 VTLKDST 125
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.123    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 623,112
Number of extensions: 1292
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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