Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001186209                                                           18    1935
NP_619515                                                              18    1935
NP_005320                                                              18    1935
XP_005255978                                                           18    1935
XP_005255977                                                           18    1935
NP_001185761                                                           17    2528
NP_001185763                                                           17    2528
NP_055459                                                              17    2528
XP_006726410                                                           17    2528
XP_006711719                                                           17    2528
XP_006711718                                                           17    2528
XP_006711717                                                           17    2528
XP_006711716                                                           17    2528
XP_006711715                                                           17    2528
XP_006711714                                                           17    2528
XP_006711713                                                           17    2528
XP_006711712                                                           17    2528
XP_006711711                                                           17    2528
XP_006711710                                                           17    2528
XP_006711709                                                           17    2528
XP_005277503                                                           17    2528
XP_005273038                                                           17    2528
XP_006711708                                                           17    2528
XP_005277500                                                           17    2528
XP_006711707                                                           17    2528
XP_005277499                                                           17    2528
XP_006711706                                                           17    2528
XP_006711705                                                           17    2528
XP_006711164                                                           17    2528
XP_006710140                                                           17    2528
XP_005254804                                                           17    4312
XP_006720791                                                           17    4312
XP_005254803                                                           17    4312
XP_005254800                                                           17    4312
XP_005254799                                                           17    4312
NP_003913                                                              17    4312
NP_001107228                                                           16    7355
NP_001244918                                                           16    7355
NP_001107227                                                           16    7355
NP_001944                                                              16    7355
NP_001244917                                                           16    7355
NP_005319                                                              16    7355
NP_001514                                                              16    7355
XP_005258891                                                           16    7355
NP_444511                                                              15    9605
NP_001092314                                                           15    9605
NP_001132986                                                           15    9605
>NP_001186209
          Length = 553

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TIELVRILE 9
           TIE++R+LE
Sbjct: 225 TIEMLRVLE 233
>NP_619515
          Length = 281

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TIELVRILE 9
           TIE++R+LE
Sbjct: 225 TIEMLRVLE 233
>NP_005320
          Length = 553

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TIELVRILE 9
           TIE++R+LE
Sbjct: 225 TIEMLRVLE 233
>XP_005255978
          Length = 553

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TIELVRILE 9
           TIE++R+LE
Sbjct: 225 TIEMLRVLE 233
>XP_005255977
          Length = 553

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TIELVRILE 9
           TIE++R+LE
Sbjct: 225 TIEMLRVLE 233
>NP_001185761
          Length = 2240

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1687 TIELGRILE 1695
>NP_001185763
          Length = 2362

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1793 TIELGRILE 1801
>NP_055459
          Length = 2346

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1793 TIELGRILE 1801
>XP_006726410
          Length = 2087

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1534 TIELGRILE 1542
>XP_006711719
          Length = 2302

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1749 TIELGRILE 1757
>XP_006711718
          Length = 1436

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TIELVRILE 9
           TIEL RILE
Sbjct: 800 TIELGRILE 808
>XP_006711717
          Length = 2385

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1749 TIELGRILE 1757
>XP_006711716
          Length = 2411

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1858 TIELGRILE 1866
>XP_006711715
          Length = 2428

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1792 TIELGRILE 1800
>XP_006711714
          Length = 2429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1793 TIELGRILE 1801
>XP_006711713
          Length = 2432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1796 TIELGRILE 1804
>XP_006711712
          Length = 2473

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_006711711
          Length = 2482

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1846 TIELGRILE 1854
>XP_006711710
          Length = 2494

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1858 TIELGRILE 1866
>XP_006711709
          Length = 2495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1859 TIELGRILE 1867
>XP_005277503
          Length = 2498

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_005273038
          Length = 2509

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_006711708
          Length = 2512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_005277500
          Length = 2525

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_006711707
          Length = 2553

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_005277499
          Length = 2561

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_006711706
          Length = 2591

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1955 TIELGRILE 1963
>XP_006711705
          Length = 2592

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1956 TIELGRILE 1964
>XP_006711164
          Length = 2087

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TIELVRILE 9
            TIEL RILE
Sbjct: 1534 TIELGRILE 1542
>XP_006710140
          Length = 290

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TIELVRILE 9
          TIEL RILE
Sbjct: 46 TIELGRILE 54
>XP_005254804
          Length = 4796

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TIELVRIL 8
            TI+L+RIL
Sbjct: 2151 TIQLIRIL 2158
>XP_006720791
          Length = 4853

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TIELVRIL 8
            TI+L+RIL
Sbjct: 2216 TIQLIRIL 2223
>XP_005254803
          Length = 4854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TIELVRIL 8
            TI+L+RIL
Sbjct: 2216 TIQLIRIL 2223
>XP_005254800
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TIELVRIL 8
            TI+L+RIL
Sbjct: 2216 TIQLIRIL 2223
>XP_005254799
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TIELVRIL 8
            TI+L+RIL
Sbjct: 2216 TIQLIRIL 2223
>NP_003913
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TIELVRIL 8
            TI+L+RIL
Sbjct: 2216 TIQLIRIL 2223
>NP_001107228
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+ELVR L
Sbjct: 388 TVELVRAL 395
>NP_001244918
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+ELVR L
Sbjct: 393 TVELVRAL 400
>NP_001107227
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+ELVR L
Sbjct: 388 TVELVRAL 395
>NP_001944
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+ELVR L
Sbjct: 388 TVELVRAL 395
>NP_001244917
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+ELVR L
Sbjct: 388 TVELVRAL 395
>NP_005319
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   TIELVRILE 9
           ++E+V++LE
Sbjct: 222 SVEMVKVLE 230
>NP_001514
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IELVRILE 9
           +ELVR+L+
Sbjct: 248 LELVRVLD 255
>XP_005258891
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IELVRILE 9
           +ELVR+L+
Sbjct: 247 LELVRVLD 254
>NP_444511
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+E VRIL
Sbjct: 124 TVEQVRIL 131
>NP_001092314
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TIELVRI 7
           TIE+VR+
Sbjct: 248 TIEMVRV 254
>NP_001132986
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TIELVRIL 8
           T+E VRIL
Sbjct: 124 TVEQVRIL 131
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.151    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 363,273
Number of extensions: 661
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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