Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     299
NP_001120972                                                           20     299
XP_006716054                                                           20     299
XP_006716053                                                           20     299
XP_006716052                                                           20     299
XP_006716051                                                           20     299
NP_055835                                                              17    2528
NP_001275932                                                           17    2528
NP_001268653                                                           17    4312
NP_000051                                                              17    4312
NP_001268654                                                           17    4312
NP_036228                                                              17    4312
NP_003290                                                              17    4312
NP_078966                                                              17    4312
NP_001268652                                                           17    4312
NP_001120691                                                           17    4312
NP_115981                                                              17    4312
XP_005253228                                                           17    4312
XP_005253227                                                           17    4312
XP_006713378                                                           17    4312
XP_006713377                                                           17    4312
XP_005265474                                                           17    4312
NP_640338                                                              16    5631
NP_002284                                                              16    7355
NP_892006                                                              16    7355
NP_149062                                                              16    7355
NP_065914                                                              16    7355
NP_001167628                                                           16    7355
NP_001276323                                                           16    7355
NP_006415                                                              16    7355
NP_001025110                                                           16    7355
NP_001161055                                                           16    7355
NP_001171470                                                           16    7355
NP_001171469                                                           16    7355
XP_006715488                                                           16    7355
XP_006715487                                                           16    7355
XP_006715486                                                           16    7355
XP_006715485                                                           16    7355
XP_006715484                                                           16    7355
XP_006715483                                                           16    7355
XP_006715482                                                           16    7355
XP_006715481                                                           16    7355
XP_006715480                                                           16    7355
XP_006715479                                                           16    7355
XP_006715478                                                           16    7355
XP_006715477                                                           16    7355
XP_006715476                                                           16    7355
XP_006715475                                                           16    7355
XP_006715474                                                           16    7355
XP_006715473                                                           16    7355
XP_006715472                                                           16    7355
XP_006715471                                                           16    7355
XP_006715470                                                           16    7355
NP_001167629                                                           16    7355
NP_006107                                                              15    9605
NP_705717                                                              15    9605
NP_001271286                                                           15    9605
NP_001185947                                                           15    9605
NP_001185946                                                           15    9605
NP_001027025                                                           15    9605
NP_066288                                                              15    9605
NP_060161                                                              15    9605
NP_036533                                                              15    9605
XP_005261968                                                           15    9605
XP_005261966                                                           15    9605
XP_005261967                                                           15    9605
XP_006724476                                                           15    9605
XP_005261965                                                           15    9605
XP_005260618                                                           15    9605
XP_005254549                                                           15    9605
NP_001118228                                                           15    9605
>NP_000236
          Length = 1390

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIANIGTSE 9
           TIAN+GTSE
Sbjct: 451 TIANLGTSE 459
>NP_001120972
          Length = 1408

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIANIGTSE 9
           TIAN+GTSE
Sbjct: 451 TIANLGTSE 459
>XP_006716054
          Length = 960

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIANIGTSE 9
          TIAN+GTSE
Sbjct: 21 TIANLGTSE 29
>XP_006716053
          Length = 960

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TIANIGTSE 9
          TIAN+GTSE
Sbjct: 21 TIANLGTSE 29
>XP_006716052
          Length = 1409

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIANIGTSE 9
           TIAN+GTSE
Sbjct: 470 TIANLGTSE 478
>XP_006716051
          Length = 1427

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TIANIGTSE 9
           TIAN+GTSE
Sbjct: 470 TIANLGTSE 478
>NP_055835
          Length = 1323

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+AN+GT +
Sbjct: 894 TVANVGTCQ 902
>NP_001275932
          Length = 1256

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+AN+GT +
Sbjct: 827 TVANVGTCQ 835
>NP_001268653
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 172 VANLGTKE 179
>NP_000051
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 170 VANLGTKE 177
>NP_001268654
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 150 VANLGTKE 157
>NP_036228
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IANIGTS 8
           +ANIGTS
Sbjct: 226 LANIGTS 232
>NP_003290
          Length = 803

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TIANIGTSE 9
           TIA  GTSE
Sbjct: 165 TIAKSGTSE 173
>NP_078966
          Length = 14507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IANIGTS 8
            +AN+GTS
Sbjct: 5720 VANVGTS 5726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    IANIGTS 8
            +AN+GT+
Sbjct: 6303 VANVGTT 6309
>NP_001268652
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 172 VANLGTKE 179
>NP_001120691
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           I N+GTSE
Sbjct: 98  IINLGTSE 105
>NP_115981
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           I N+GTSE
Sbjct: 98  IINLGTSE 105
>XP_005253228
          Length = 475

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           I N+GTSE
Sbjct: 98  IINLGTSE 105
>XP_005253227
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           I N+GTSE
Sbjct: 98  IINLGTSE 105
>XP_006713378
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 150 VANLGTKE 157
>XP_006713377
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 150 VANLGTKE 157
>XP_005265474
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +AN+GT E
Sbjct: 150 VANLGTKE 157
>NP_640338
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TIANIGTS 8
           T+AN+G S
Sbjct: 206 TVANVGDS 213
>NP_002284
          Length = 1609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IANIGTSE 9
            IAN+GT +
Sbjct: 1056 IANLGTGD 1063
>NP_892006
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>NP_149062
          Length = 8749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>NP_065914
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANIGTSE 9
            AN+GT E
Sbjct: 1023 ANVGTGE 1029
>NP_001167628
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ANIGTSE 9
           AN+GT E
Sbjct: 961 ANVGTGE 967
>NP_001276323
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANIGTSE 9
            AN+GT E
Sbjct: 1011 ANVGTGE 1017
>NP_006415
          Length = 690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ANIGTS 8
           ANIGTS
Sbjct: 188 ANIGTS 193
>NP_001025110
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANIGTSE 9
            AN+GT E
Sbjct: 1011 ANVGTGE 1017
>NP_001161055
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANIGTSE 9
            AN+GT E
Sbjct: 1011 ANVGTGE 1017
>NP_001171470
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ANIGTS 8
           ANIGTS
Sbjct: 187 ANIGTS 192
>NP_001171469
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ANIGTS 8
           ANIGTS
Sbjct: 187 ANIGTS 192
>XP_006715488
          Length = 8721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715487
          Length = 8744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715486
          Length = 8758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715485
          Length = 8793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715484
          Length = 8794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715483
          Length = 8795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715482
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715481
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 42 VANIGTA 48
>XP_006715480
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715479
          Length = 8804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715478
          Length = 8809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715477
          Length = 8822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715476
          Length = 8823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715475
          Length = 8827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715474
          Length = 8829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715473
          Length = 8832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715472
          Length = 8839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715471
          Length = 8842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>XP_006715470
          Length = 8846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IANIGTS 8
          +ANIGT+
Sbjct: 89 VANIGTA 95
>NP_001167629
          Length = 1145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ANIGTSE 9
            AN+GT E
Sbjct: 1011 ANVGTGE 1017
>NP_006107
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IANIGTS 8
           +AN+GT+
Sbjct: 180 VANVGTN 186
>NP_705717
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IANIGTS 8
           +AN+GT+
Sbjct: 180 VANVGTN 186
>NP_001271286
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +ANI T+E
Sbjct: 346 VANIATNE 353
>NP_001185947
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +ANI T+E
Sbjct: 312 VANIATNE 319
>NP_001185946
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +ANI T+E
Sbjct: 361 VANIATNE 368
>NP_001027025
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NIGTSE 9
           N+GTSE
Sbjct: 172 NLGTSE 177
>NP_066288
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TIANIGTS 8
           T+AN+G +
Sbjct: 102 TVANVGAA 109
>NP_060161
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IANIGTSE 9
           +ANI T+E
Sbjct: 356 VANIATNE 363
>NP_036533
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+A +GTS+
Sbjct: 404 TVAFLGTSD 412
>XP_005261968
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+A +GTS+
Sbjct: 404 TVAFLGTSD 412
>XP_005261966
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+A +GTS+
Sbjct: 404 TVAFLGTSD 412
>XP_005261967
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+A +GTS+
Sbjct: 404 TVAFLGTSD 412
>XP_006724476
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+A +GTS+
Sbjct: 404 TVAFLGTSD 412
>XP_005261965
          Length = 1920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TIANIGTSE 9
           T+A +GTS+
Sbjct: 486 TVAFLGTSD 494
>XP_005260618
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IANIGT 7
           +ANIGT
Sbjct: 481 VANIGT 486
>XP_005254549
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IANIGTSE 9
          +ANI T+E
Sbjct: 62 VANIATNE 69
>NP_001118228
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IANIGT 7
           +ANIGT
Sbjct: 481 VANIGT 486
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.118    0.289 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 366,822
Number of extensions: 547
Number of successful extensions: 72
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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