Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     869
XP_006717990                                                           19     869
XP_006717989                                                           19     869
NP_055826                                                              17    3301
NP_001185879                                                           17    3301
NP_078863                                                              17    4312
XP_005271253                                                           17    4312
XP_005271252                                                           17    4312
XP_005271251                                                           17    4312
NP_689635                                                              16    5631
NP_001240759                                                           16    5631
NP_818931                                                              16    5631
NP_001240758                                                           16    5631
NP_000444                                                              16    5631
NP_666018                                                              16    5631
NP_036565                                                              16    5631
NP_848593                                                              16    5631
XP_006718220                                                           16    5631
XP_006718219                                                           16    5631
XP_006718218                                                           16    5631
XP_006717021                                                           16    5631
XP_005251769                                                           16    5631
XP_006717020                                                           16    5631
XP_005251768                                                           16    5631
XP_005246485                                                           16    5631
NP_001074295                                                           16    7355
NP_079052                                                              16    7355
NP_877950                                                              16    7355
NP_689616                                                              16    7355
NP_001192230                                                           16    7355
NP_001191006                                                           16    7355
NP_004779                                                              16    7355
XP_005254732                                                           16    7355
XP_005254731                                                           16    7355
XP_006720754                                                           16    7355
XP_005254729                                                           16    7355
XP_005254730                                                           16    7355
XP_005254728                                                           16    7355
XP_005254727                                                           16    7355
XP_005272427                                                           16    7355
XP_005272426                                                           16    7355
XP_006714503                                                           16    7355
NP_001005199                                                           16    7355
NP_001005201                                                           16    7355
NP_001001914                                                           16    7355
NP_001165881                                                           15    9605
NP_001165828                                                           15    9605
NP_001416                                                              15    9605
NP_003009                                                              15    9605
NP_006242                                                              15    9605
NP_996790                                                              15    9605
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_954868                                                              15    9605
NP_620598                                                              15    9605
NP_620599                                                              15    9605
NP_004348                                                              15    9605
NP_954869                                                              15    9605
NP_001034579                                                           15    9605
NP_001277153                                                           15    9605
NP_954870                                                              15    9605
NP_004781                                                              15    9605
NP_695008                                                              15    9605
NP_695010                                                              15    9605
NP_695009                                                              15    9605
NP_937822                                                              15    9605
NP_009158                                                              15    9605
XP_006716443                                                           15    9605
XP_006716442                                                           15    9605
XP_005273655                                                           15    9605
XP_006714544                                                           15    9605
>NP_000305
          Length = 403

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGVMIYAYL 9
           TGVMI AYL
Sbjct: 131 TGVMICAYL 139
>XP_006717990
          Length = 175

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGVMIYAYL 9
           TGVMI AYL
Sbjct: 116 TGVMICAYL 124
>XP_006717989
          Length = 388

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGVMIYAYL 9
           TGVMI AYL
Sbjct: 116 TGVMICAYL 124
>NP_055826
          Length = 1858

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGVMIYAYL 9
           TG  IY YL
Sbjct: 569 TGARIYTYL 577
>NP_001185879
          Length = 1880

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGVMIYAYL 9
           TG  IY YL
Sbjct: 591 TGARIYTYL 599
>NP_078863
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVMIYAYL 9
           GVM+Y Y+
Sbjct: 116 GVMLYRYV 123
>XP_005271253
          Length = 204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GVMIYAYL 9
          GVM+Y Y+
Sbjct: 43 GVMLYRYV 50
>XP_005271252
          Length = 246

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GVMIYAYL 9
          GVM+Y Y+
Sbjct: 85 GVMLYRYV 92
>XP_005271251
          Length = 247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GVMIYAYL 9
          GVM+Y Y+
Sbjct: 86 GVMLYRYV 93
>NP_689635
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 249 TGVLIACYL 257
>NP_001240759
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 197 TGVLIACYL 205
>NP_818931
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 197 TGVLIACYL 205
>NP_001240758
          Length = 808

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 251 TGVLIACYL 259
>NP_000444
          Length = 643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TGVMIYA 7
           TG++IYA
Sbjct: 145 TGIVIYA 151
>NP_666018
          Length = 610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TGVMIYA 7
           TG++IYA
Sbjct: 143 TGIVIYA 149
>NP_036565
          Length = 1304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVMIYAYL 9
           GV++Y YL
Sbjct: 975 GVVLYEYL 982
>NP_848593
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TGVMIYA 7
           TGV++YA
Sbjct: 139 TGVVVYA 145
>XP_006718220
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TGVMIYA 7
           TGV++YA
Sbjct: 139 TGVVVYA 145
>XP_006718219
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TGVMIYA 7
           TGV++YA
Sbjct: 139 TGVVVYA 145
>XP_006718218
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TGVMIYA 7
          TGV++YA
Sbjct: 28 TGVVVYA 34
>XP_006717021
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TGVMIYAYL 9
          TGV+I  YL
Sbjct: 73 TGVLIACYL 81
>XP_005251769
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 146 TGVLIACYL 154
>XP_006717020
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 197 TGVLIACYL 205
>XP_005251768
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TGV+I  YL
Sbjct: 197 TGVLIACYL 205
>XP_005246485
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVMIYAYL 9
           GV++Y YL
Sbjct: 829 GVVLYEYL 836
>NP_001074295
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1257 TGILIYELL 1265
>NP_079052
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>NP_877950
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GVMIYAY 8
           GV++Y+Y
Sbjct: 414 GVLLYSY 420
>NP_689616
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GVMIYAY 8
           GV++Y+Y
Sbjct: 648 GVLLYSY 654
>NP_001192230
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GVMIYAY 8
           GV++Y+Y
Sbjct: 648 GVLLYSY 654
>NP_001191006
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VMIYAYL 9
           +++YAYL
Sbjct: 288 ILLYAYL 294
>NP_004779
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VMIYAYL 9
           +++YAYL
Sbjct: 295 ILLYAYL 301
>XP_005254732
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_005254731
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_006720754
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_005254729
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_005254730
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_005254728
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_005254727
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1595 TGILIYEML 1603
>XP_005272427
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1257 TGILIYELL 1265
>XP_005272426
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TGVMIYAYL 9
            TG++IY  L
Sbjct: 1257 TGILIYELL 1265
>XP_006714503
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GVMIYAY 8
           GV++Y+Y
Sbjct: 648 GVLLYSY 654
>NP_001005199
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G MI+ YL
Sbjct: 252 GTMIFTYL 259
>NP_001005201
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G MI+ YL
Sbjct: 253 GTMIFTYL 260
>NP_001001914
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G +IY YL
Sbjct: 253 GTIIYVYL 260
>NP_001165881
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGVMIYAY 8
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>NP_001165828
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGVMIYAY 8
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>NP_001416
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TGVMIYA 7
           TG +IYA
Sbjct: 113 TGALIYA 119
>NP_003009
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGVMIYAY 8
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>NP_006242
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGVMIYAYL 9
           +GV++YA L
Sbjct: 211 SGVILYALL 219
>NP_996790
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGVMIYAYL 9
           +GV++YA L
Sbjct: 226 SGVILYALL 234
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TGVMIYAY 8
            TGV  Y+Y
Sbjct: 2047 TGVQSYSY 2054
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TGVMIYAY 8
            TGV  Y+Y
Sbjct: 2047 TGVQSYSY 2054
>NP_954868
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TG M+ A+L
Sbjct: 327 TGTMVCAFL 335
>NP_620598
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GVMIYAY 8
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_620599
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GVMIYAY 8
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_004348
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GVMIYAY 8
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_954869
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TG M+ A+L
Sbjct: 307 TGTMVCAFL 315
>NP_001034579
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GVMIYAY 8
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_001277153
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TG M+ A+L
Sbjct: 207 TGTMVCAFL 215
>NP_954870
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGVMIYAYL 9
           TG M+ A+L
Sbjct: 345 TGTMVCAFL 353
>NP_004781
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G M++ YL
Sbjct: 148 GAMVFGYL 155
>NP_695008
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G M++ YL
Sbjct: 148 GAMVFGYL 155
>NP_695010
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G M++ YL
Sbjct: 148 GAMVFGYL 155
>NP_695009
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   GVMIYAYL 9
           G M++ YL
Sbjct: 148 GAMVFGYL 155
>NP_937822
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TGVMIYA 7
          TGV+I+A
Sbjct: 51 TGVLIFA 57
>NP_009158
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVMIYAYL 9
           GVM+ AY+
Sbjct: 209 GVMLCAYM 216
>XP_006716443
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGVMIYAY 8
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>XP_006716442
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGVMIYAY 8
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>XP_005273655
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGVMIYAY 8
           TG+++Y Y
Sbjct: 148 TGLVVYDY 155
>XP_006714544
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGVMIYAYL 9
           +GV++YA L
Sbjct: 110 SGVILYALL 118
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.148    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 366,900
Number of extensions: 681
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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