Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           19     869
NP_001277143                                                           19     869
NP_001077383                                                           19     869
NP_001320                                                              19     869
NP_073713                                                              19     869
XP_005269629                                                           19     869
XP_005269628                                                           19     869
XP_005269627                                                           19     869
XP_005269626                                                           19     869
XP_006717706                                                           19     869
XP_005269625                                                           19     869
XP_005269624                                                           19     869
XP_006717705                                                           19     869
XP_005269622                                                           19     869
XP_005269621                                                           19     869
XP_006717704                                                           19     869
XP_005269619                                                           19     869
XP_005269618                                                           19     869
NP_006273                                                              17    3301
NP_001269165                                                           17    3301
NP_003322                                                              17    3301
NP_004187                                                              17    3301
XP_005260590                                                           17    3301
XP_006723933                                                           17    3301
XP_005260589                                                           17    3301
XP_005260588                                                           17    3301
XP_005260587                                                           17    3301
XP_005268216                                                           17    3301
XP_005268215                                                           17    3301
XP_005268214                                                           17    3301
XP_005268213                                                           17    3301
XP_006714709                                                           17    3301
XP_006714708                                                           17    3301
XP_006714707                                                           17    3301
XP_006714706                                                           17    3301
XP_006714705                                                           17    3301
NP_001107047                                                           17    3301
NP_057592                                                              17    3301
NP_004963                                                              17    4312
NP_001163878                                                           17    4312
NP_001163877                                                           17    4312
NP_001777                                                              17    4312
NP_203698                                                              17    4312
XP_006718146                                                           17    4312
XP_006718145                                                           17    4312
XP_005270360                                                           17    4312
XP_005251512                                                           17    4312
NP_620590                                                              16    5631
NP_001009565                                                           16    5631
XP_006725141                                                           16    5631
XP_006725140                                                           16    5631
XP_005258110                                                           16    5631
XP_006716592                                                           16    5631
XP_006716591                                                           16    5631
XP_006712067                                                           16    5631
XP_006712066                                                           16    5631
NP_001243241                                                           16    7355
NP_006272                                                              16    7355
NP_001243242                                                           16    7355
NP_001277159                                                           15    9605
NP_001789                                                              15    9605
NP_439892                                                              15    9605
NP_660186                                                              15    9605
NP_065802                                                              15    9605
NP_001138551                                                           15    9605
NP_001643                                                              15    9605
NP_003939                                                              15    9605
NP_001072                                                              15    9605
XP_005272547                                                           15    9605
XP_005272546                                                           15    9605
XP_006722863                                                           15    9605
XP_006714470                                                           15    9605
XP_006714469                                                           15    9605
XP_005263392                                                           15    9605
NP_722578                                                              15    9605
>NP_001277144
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>NP_001277143
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>NP_001077383
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>NP_001320
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>NP_073713
          Length = 985

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 731 TGQAVAVRA 739
>XP_005269629
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269628
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269627
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269626
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_006717706
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269625
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269624
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_006717705
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269622
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269621
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_006717704
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269619
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>XP_005269618
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGQVVAVRA 9
           TGQ VAVRA
Sbjct: 191 TGQAVAVRA 199
>NP_006273
          Length = 487

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 52 TGQIVAIK 59
>NP_001269165
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 27 TGQIVAIK 34
>NP_003322
          Length = 1187

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TGQVVAVRA 9
           TG++VAV+A
Sbjct: 923 TGEMVAVKA 931
>NP_004187
          Length = 358

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 27 TGQIVAIK 34
>XP_005260590
          Length = 462

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 52 TGQIVAIK 59
>XP_006723933
          Length = 474

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 39 TGQIVAIK 46
>XP_005260589
          Length = 474

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 39 TGQIVAIK 46
>XP_005260588
          Length = 478

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 68 TGQIVAIK 75
>XP_005260587
          Length = 503

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 68 TGQIVAIK 75
>XP_005268216
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 27 TGQIVAIK 34
>XP_005268215
          Length = 339

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 27 TGQIVAIK 34
>XP_005268214
          Length = 358

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 27 TGQIVAIK 34
>XP_005268213
          Length = 993

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TGQVVAVR 8
           TGQ+VA++
Sbjct: 216 TGQIVAIK 223
>XP_006714709
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>XP_006714708
          Length = 602

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>XP_006714707
          Length = 602

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>XP_006714706
          Length = 603

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>XP_006714705
          Length = 604

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>NP_001107047
          Length = 592

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>NP_057592
          Length = 455

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQ+VA++
Sbjct: 26 TGQIVAIK 33
>NP_004963
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TGQVVAVR 8
           TG+VVAV+
Sbjct: 875 TGEVVAVK 882
>NP_001163878
          Length = 109

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>NP_001163877
          Length = 109

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>NP_001777
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>NP_203698
          Length = 240

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>XP_006718146
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>XP_006718145
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>XP_005270360
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TGQVVA++
Sbjct: 26 TGQVVAMK 33
>XP_005251512
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TGQVVAVR 8
           TG+VVAV+
Sbjct: 875 TGEVVAVK 882
>NP_620590
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 35 TGEVVAIK 42
>NP_001009565
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          +GQVVAV+
Sbjct: 26 SGQVVAVK 33
>XP_006725141
          Length = 325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 35 TGEVVAIK 42
>XP_006725140
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 35 TGEVVAIK 42
>XP_005258110
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GQVVAVRA 9
           GQVVAV A
Sbjct: 207 GQVVAVSA 214
>XP_006716592
          Length = 325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 35 TGEVVAIK 42
>XP_006716591
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 35 TGEVVAIK 42
>XP_006712067
          Length = 175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          +GQVVAV+
Sbjct: 26 SGQVVAVK 33
>XP_006712066
          Length = 342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          +GQVVAV+
Sbjct: 26 SGQVVAVK 33
>NP_001243241
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          +GQVVA++
Sbjct: 77 SGQVVAIK 84
>NP_006272
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          +GQVVA++
Sbjct: 49 SGQVVAIK 56
>NP_001243242
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          +GQVVA++
Sbjct: 49 SGQVVAIK 56
>NP_001277159
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 26 TGEVVALK 33
>NP_001789
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 26 TGEVVALK 33
>NP_439892
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG+VVA++
Sbjct: 26 TGEVVALK 33
>NP_660186
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TGQVVAVR 8
           TG V+AV+
Sbjct: 142 TGHVIAVK 149
>NP_065802
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TGQVVAVRA 9
          +G+VVAV A
Sbjct: 5  SGEVVAVSA 13
>NP_001138551
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TGQVVAVRA 9
          +G+VVAV A
Sbjct: 5  SGEVVAVSA 13
>NP_001643
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TGQVVAV 7
           TGQ VAV
Sbjct: 141 TGQAVAV 147
>NP_003939
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG++VA++
Sbjct: 26 TGRIVAIK 33
>NP_001072
          Length = 3623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TGQVVAV 7
            TGQ++AV
Sbjct: 1082 TGQLIAV 1088
>XP_005272547
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TGQVVAVR 8
           TG V+AV+
Sbjct: 142 TGHVIAVK 149
>XP_005272546
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TGQVVAVR 8
           TG V+AV+
Sbjct: 158 TGHVIAVK 165
>XP_006722863
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TGQVVAVR 8
           TG V+AV+
Sbjct: 158 TGHVIAVK 165
>XP_006714470
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG++VA++
Sbjct: 26 TGRIVAIK 33
>XP_006714469
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG++VA++
Sbjct: 26 TGRIVAIK 33
>XP_005263392
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TGQVVAVR 8
          TG++VA++
Sbjct: 26 TGRIVAIK 33
>NP_722578
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TGQVVAV 7
           TGQ++AV
Sbjct: 221 TGQMIAV 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.127    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,987
Number of extensions: 505
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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