Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     390
XP_005262424                                                           20     390
NP_840054                                                              18    1135
XP_005262121                                                           18    1135
NP_443168                                                              18    1135
NP_001188333                                                           18    1935
NP_008921                                                              18    1935
NP_000114                                                              17    4312
NP_001191354                                                           17    4312
NP_775871                                                              17    4312
NP_005318                                                              16    5631
NP_001171634                                                           16    5631
NP_002668                                                              16    5631
XP_005263029                                                           16    5631
NP_852002                                                              16    5631
NP_001156956                                                           16    5631
NP_079506                                                              16    5631
NP_055483                                                              16    7355
NP_036595                                                              16    7355
XP_006719381                                                           16    7355
XP_006719380                                                           16    7355
XP_006711971                                                           16    7355
XP_005246252                                                           16    7355
XP_006711970                                                           16    7355
XP_006711969                                                           16    7355
XP_005246249                                                           16    7355
XP_006711968                                                           16    7355
XP_006711967                                                           16    7355
NP_006506                                                              15    9605
NP_001243778                                                           15    9605
NP_002682                                                              15    9605
NP_733793                                                              15    9605
NP_004832                                                              15    9605
NP_001230652                                                           15    9605
NP_002588                                                              15    9605
NP_056235                                                              15    9605
NP_150229                                                              15    9605
NP_079215                                                              15    9605
NP_619636                                                              15    9605
XP_005259065                                                           15    9605
XP_006723311                                                           15    9605
XP_005259064                                                           15    9605
XP_005259063                                                           15    9605
XP_006721337                                                           15    9605
XP_006721336                                                           15    9605
XP_005256210                                                           15    9605
XP_006713360                                                           15    9605
XP_006713358                                                           15    9605
XP_006713357                                                           15    9605
XP_006713356                                                           15    9605
XP_006713355                                                           15    9605
XP_005245679                                                           15    9605
XP_005245678                                                           15    9605
XP_005245677                                                           15    9605
XP_006711697                                                           15    9605
NP_072098                                                              15    9605
>NP_722576
          Length = 3080

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   GQEFIEST 9
           GQEFIEST
Sbjct: 434 GQEFIEST 441
>XP_005262424
          Length = 2875

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   GQEFIEST 9
           GQEFIEST
Sbjct: 229 GQEFIEST 236
>NP_840054
          Length = 336

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EFI+ST
Sbjct: 311 TGAEFIDST 319
>XP_005262121
          Length = 321

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EFI+ST
Sbjct: 296 TGAEFIDST 304
>NP_443168
          Length = 398

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EFI+ST
Sbjct: 373 TGAEFIDST 381
>NP_001188333
          Length = 281

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQEFIES 8
           GQEF+ES
Sbjct: 209 GQEFVES 215
>NP_008921
          Length = 498

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQEFIES 8
           GQEF+ES
Sbjct: 209 GQEFVES 215
>NP_000114
          Length = 1186

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQEFIES 8
           TGQ F+ES
Sbjct: 765 TGQMFLES 772
>NP_001191354
          Length = 1640

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TGQEFIES 8
            TGQ F+ES
Sbjct: 1219 TGQMFLES 1226
>NP_775871
          Length = 8384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TGQEFIES 8
            TG+ FIES
Sbjct: 2273 TGKSFIES 2280
>NP_005318
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GQEFIEST 9
          G EF+E T
Sbjct: 89 GDEFVEKT 96
>NP_001171634
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GQEFIEST 9
          G EF+E T
Sbjct: 89 GDEFVEKT 96
>NP_002668
          Length = 132

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GQEFIEST 9
          GQEF E+T
Sbjct: 68 GQEFEETT 75
>XP_005263029
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GQEFIEST 9
           G EF+E T
Sbjct: 93  GDEFVEKT 100
>NP_852002
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQEFIES 8
           TGQ+FI S
Sbjct: 425 TGQQFIYS 432
>NP_001156956
          Length = 546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQEFIES 8
           TGQ+FI S
Sbjct: 451 TGQQFIYS 458
>NP_079506
          Length = 546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGQEFIES 8
           TGQ+FI S
Sbjct: 451 TGQQFIYS 458
>NP_055483
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>NP_036595
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TGQE+++
Sbjct: 643 TGQEYVQ 649
>XP_006719381
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TGQE+++
Sbjct: 369 TGQEYVQ 375
>XP_006719380
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TGQE+++
Sbjct: 472 TGQEYVQ 478
>XP_006711971
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>XP_005246252
          Length = 1850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 760 EFIEST 765
>XP_006711970
          Length = 1948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>XP_006711969
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>XP_005246249
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>XP_006711968
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>XP_006711967
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EFIEST 9
           EFIEST
Sbjct: 859 EFIEST 864
>NP_006506
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 650 QEFVES 655
>NP_001243778
          Length = 1107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EF++++
Sbjct: 642 TGDEFVKTS 650
>NP_002682
          Length = 1107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EF++++
Sbjct: 642 TGDEFVKTS 650
>NP_733793
          Length = 1280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG++F+E
Sbjct: 406 TGRQFVE 412
>NP_004832
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG++F+E
Sbjct: 258 TGRQFVE 264
>NP_001230652
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 511 QEFVES 516
>NP_002588
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TGQEFIES 8
           TG++F+E+
Sbjct: 119 TGKQFLET 126
>NP_056235
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG+EF+ ++
Sbjct: 445 TGKEFVSAS 453
>NP_150229
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TGQEFIES 8
           TG EF+++
Sbjct: 752 TGSEFVDT 759
>NP_079215
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG+EF++
Sbjct: 323 TGEEFVK 329
>NP_619636
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GQEFIEST 9
           GQEF+  T
Sbjct: 521 GQEFVRLT 528
>XP_005259065
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EF++++
Sbjct: 642 TGDEFVKTS 650
>XP_006723311
          Length = 1109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EF++++
Sbjct: 668 TGDEFVKTS 676
>XP_005259064
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EF++++
Sbjct: 668 TGDEFVKTS 676
>XP_005259063
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TGQEFIEST 9
           TG EF++++
Sbjct: 668 TGDEFVKTS 676
>XP_006721337
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG+EF++
Sbjct: 197 TGEEFVK 203
>XP_006721336
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG+EF++
Sbjct: 197 TGEEFVK 203
>XP_005256210
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG+EF++
Sbjct: 322 TGEEFVK 328
>XP_006713360
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 328 QEFVES 333
>XP_006713358
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 362 QEFVES 367
>XP_006713357
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 394 QEFVES 399
>XP_006713356
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 394 QEFVES 399
>XP_006713355
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QEFIES 8
           QEF+ES
Sbjct: 414 QEFVES 419
>XP_005245679
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG++F+E
Sbjct: 258 TGRQFVE 264
>XP_005245678
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG++F+E
Sbjct: 261 TGRQFVE 267
>XP_005245677
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG++F+E
Sbjct: 289 TGRQFVE 295
>XP_006711697
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TGQEFIE 7
           TG++F+E
Sbjct: 298 TGRQFVE 304
>NP_072098
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TGQEFIES 8
          TG++F+E+
Sbjct: 67 TGKQFLET 74
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.122    0.311 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 543,175
Number of extensions: 1170
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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