Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     665
NP_000391                                                              17    4312
XP_005258696                                                           17    4312
NP_005236                                                              16    5631
XP_006714202                                                           16    5631
XP_005262892                                                           16    5631
XP_005262891                                                           16    5631
NP_004037                                                              16    7355
NP_001001937                                                           16    7355
NP_001244264                                                           16    7355
NP_001001935                                                           16    7355
NP_689544                                                              16    7355
NP_114120                                                              16    7355
NP_001010883                                                           16    7355
NP_001032238                                                           16    7355
NP_001244263                                                           16    7355
NP_006812                                                              16    7355
XP_005276505                                                           16    7355
XP_005268309                                                           16    7355
XP_006720336                                                           16    7355
XP_006720335                                                           16    7355
XP_006720097                                                           16    7355
NP_000083                                                              15    9605
NP_001035373                                                           15    9605
NP_000148                                                              15    9605
NP_001005742                                                           15    9605
NP_001165282                                                           15    9605
NP_001005741                                                           15    9605
NP_000017                                                              15    9605
NP_071926                                                              15    9605
NP_066013                                                              15    9605
NP_001029345                                                           15    9605
NP_001012303                                                           15    9605
NP_006208                                                              15    9605
XP_006726274                                                           15    9605
XP_005259205                                                           15    9605
XP_005259203                                                           15    9605
XP_006723383                                                           15    9605
XP_006720685                                                           15    9605
XP_005268179                                                           15    9605
XP_006720330                                                           15    9605
XP_006714856                                                           15    9605
XP_005268556                                                           15    9605
XP_006714855                                                           15    9605
XP_006714854                                                           15    9605
XP_005268555                                                           15    9605
XP_005268554                                                           15    9605
XP_005265384                                                           15    9605
XP_006712315                                                           15    9605
XP_006712314                                                           15    9605
XP_005246339                                                           15    9605
XP_006712313                                                           15    9605
XP_006712312                                                           15    9605
XP_006712311                                                           15    9605
XP_006712310                                                           15    9605
XP_006712309                                                           15    9605
XP_005246338                                                           15    9605
XP_006711333                                                           15    9605
NP_001116850                                                           15    9605
>NP_443179
          Length = 2170

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGMTLILEP 9
           TGMTLIL P
Sbjct: 427 TGMTLILGP 435
>NP_000391
          Length = 760

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G T+I+EP
Sbjct: 413 GFTIIIEP 420
>XP_005258696
          Length = 736

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G T+I+EP
Sbjct: 389 GFTIIIEP 396
>NP_005236
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+  ILEP
Sbjct: 417 TGLISILEP 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGMTLILEP 9
           TGM  IL P
Sbjct: 771 TGMLKILSP 779
>XP_006714202
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+  ILEP
Sbjct: 417 TGLISILEP 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGMTLILEP 9
           TGM  IL P
Sbjct: 771 TGMLKILSP 779
>XP_005262892
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+  ILEP
Sbjct: 417 TGLISILEP 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGMTLILEP 9
           TGM  IL P
Sbjct: 771 TGMLKILSP 779
>XP_005262891
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+  ILEP
Sbjct: 417 TGLISILEP 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGMTLILEP 9
           TGM  IL P
Sbjct: 771 TGMLKILSP 779
>NP_004037
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           GM+L LEP
Sbjct: 104 GMSLNLEP 111
>NP_001001937
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           GM+L LEP
Sbjct: 104 GMSLNLEP 111
>NP_001244264
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GMTLILEP 9
          GM+L LEP
Sbjct: 54 GMSLNLEP 61
>NP_001001935
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GMTLILEP 9
          GM+L LEP
Sbjct: 54 GMSLNLEP 61
>NP_689544
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLILEP 9
         TLILEP
Sbjct: 4 TLILEP 9
>NP_114120
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MTLILEP 9
           +TL+LEP
Sbjct: 467 VTLVLEP 473
>NP_001010883
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+  ILEP
Sbjct: 245 TGVESILEP 253
>NP_001032238
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLILEP 9
         TLILEP
Sbjct: 4 TLILEP 9
>NP_001244263
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           GM+L LEP
Sbjct: 104 GMSLNLEP 111
>NP_006812
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  TLILEP 9
          TLILEP
Sbjct: 66 TLILEP 71
>XP_005276505
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLILEP 9
         TLILEP
Sbjct: 4 TLILEP 9
>XP_005268309
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLILEP 9
         TLILEP
Sbjct: 4 TLILEP 9
>XP_006720336
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MTLILEP 9
           +TL+LEP
Sbjct: 396 VTLVLEP 402
>XP_006720335
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MTLILEP 9
           +TL+LEP
Sbjct: 467 VTLVLEP 473
>XP_006720097
          Length = 167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 TLILEP 9
         TLILEP
Sbjct: 4 TLILEP 9
>NP_000083
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>NP_001035373
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           T  TLIL+P
Sbjct: 252 THSTLILQP 260
>NP_000148
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+ L L+P
Sbjct: 102 TGLLLTLQP 110
>NP_001005742
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+ L L+P
Sbjct: 102 TGLLLTLQP 110
>NP_001165282
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TGMTLILEP 9
          TG+ L L+P
Sbjct: 15 TGLLLTLQP 23
>NP_001005741
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+ L L+P
Sbjct: 102 TGLLLTLQP 110
>NP_000017
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MTLILEP 9
           MTL+++P
Sbjct: 312 MTLVMDP 318
>NP_071926
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1293 GFTLILE 1299
>NP_066013
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TGMTLILE 8
            TG TL+L+
Sbjct: 1099 TGQTLLLQ 1106
>NP_001029345
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL+L+P
Sbjct: 612 GNTLVLKP 619
>NP_001012303
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GMTLILE 8
          G+TL+LE
Sbjct: 61 GITLVLE 67
>NP_006208
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GMTLILE 8
          G+TL+LE
Sbjct: 51 GITLVLE 57
>XP_006726274
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+ L L+P
Sbjct: 102 TGLLLTLQP 110
>XP_005259205
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           T  TLIL+P
Sbjct: 252 THSTLILQP 260
>XP_005259203
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           T  TLIL+P
Sbjct: 255 THSTLILQP 263
>XP_006723383
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           T  TLIL+P
Sbjct: 252 THSTLILQP 260
>XP_006720685
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TGMTLILE 8
           TG TL+L+
Sbjct: 514 TGQTLLLQ 521
>XP_005268179
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGMTLILEP 9
           TGM L  EP
Sbjct: 277 TGMLLQFEP 285
>XP_006720330
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TGMTLILEP 9
           TGM L  EP
Sbjct: 479 TGMLLQFEP 487
>XP_006714856
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1095 GFTLILE 1101
>XP_005268556
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1215 GFTLILE 1221
>XP_006714855
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1222 GFTLILE 1228
>XP_006714854
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1235 GFTLILE 1241
>XP_005268555
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1273 GFTLILE 1279
>XP_005268554
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    GMTLILE 8
            G TLILE
Sbjct: 1293 GFTLILE 1299
>XP_005265384
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           T  TL+L+P
Sbjct: 524 TAATLLLDP 532
>XP_006712315
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006712314
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_005246339
          Length = 1505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006712313
          Length = 1608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006712312
          Length = 1611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006712311
          Length = 1612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006712310
          Length = 1612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006712309
          Length = 1627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_005246338
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTLILEP 9
           G TL++EP
Sbjct: 255 GPTLLVEP 262
>XP_006711333
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TGMTLILEP 9
           TG+ L L+P
Sbjct: 102 TGLLLTLQP 110
>NP_001116850
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MTLILEP 9
           MTL+++P
Sbjct: 312 MTLVMDP 318
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.141    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 504,410
Number of extensions: 891
Number of successful extensions: 63
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package