Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              19     869
XP_005264617                                                           18    1482
NP_001136155                                                           18    1482
NP_001001991                                                           17    2528
NP_001269605                                                           17    2528
NP_056245                                                              17    2528
NP_001269604                                                           17    2528
NP_066973                                                              17    2528
NP_001171545                                                           17    2528
XP_005268816                                                           17    2528
XP_005268815                                                           17    2528
XP_005268814                                                           17    2528
XP_005268813                                                           17    2528
XP_005268812                                                           17    2528
XP_005268811                                                           17    2528
NP_004095                                                              17    4312
NP_114160                                                              17    4312
NP_001073892                                                           17    4312
XP_005254003                                                           17    4312
XP_005254002                                                           17    4312
XP_005272295                                                           16    5631
NP_004651                                                              16    7355
NP_001116137                                                           16    7355
NP_001347                                                              16    7355
NP_001180346                                                           16    7355
NP_001180345                                                           16    7355
XP_006724941                                                           16    7355
XP_005262621                                                           16    7355
XP_006724940                                                           16    7355
NP_004930                                                              15    9605
NP_001075224                                                           15    9605
NP_001265844                                                           15    9605
NP_000492                                                              15    9605
NP_001265842                                                           15    9605
NP_001265846                                                           15    9605
NP_001265843                                                           15    9605
NP_001265868                                                           15    9605
NP_061722                                                              15    9605
NP_001136099                                                           15    9605
NP_001136100                                                           15    9605
NP_060614                                                              15    9605
XP_006715941                                                           15    9605
XP_006715939                                                           15    9605
XP_006715937                                                           15    9605
XP_005250245                                                           15    9605
XP_005250244                                                           15    9605
NP_114089                                                              15    9605
>NP_002430
          Length = 1137

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TGGIAARSY 9
            T GIAARSY
Sbjct: 1060 TRGIAARSY 1068
>XP_005264617
          Length = 442

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TGGIAARSY 9
          TGG AAR+Y
Sbjct: 30 TGGPAARAY 38
>NP_001136155
          Length = 440

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TGGIAARSY 9
          TGG AAR+Y
Sbjct: 30 TGGPAARAY 38
>NP_001001991
          Length = 720

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGGIAARSY 9
           TGGIAA S+
Sbjct: 665 TGGIAAVSF 673
>NP_001269605
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGGIAARSY 9
           TGGIAA S+
Sbjct: 554 TGGIAAVSF 562
>NP_056245
          Length = 737

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGGIAARSY 9
           TGGIAA S+
Sbjct: 682 TGGIAAVSF 690
>NP_001269604
          Length = 680

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TGGIAARSY 9
           TGGIAA S+
Sbjct: 625 TGGIAAVSF 633
>NP_066973
          Length = 1076

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 86 GGIAARS 92
>NP_001171545
          Length = 1061

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 86 GGIAARS 92
>XP_005268816
          Length = 1062

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 87 GGIAARS 93
>XP_005268815
          Length = 1077

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 87 GGIAARS 93
>XP_005268814
          Length = 1102

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 60 GGIAARS 66
>XP_005268813
          Length = 1114

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 87 GGIAARS 93
>XP_005268812
          Length = 1128

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 87 GGIAARS 93
>XP_005268811
          Length = 1129

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  GGIAARS 8
          GGIAARS
Sbjct: 87 GGIAARS 93
>NP_004095
          Length = 2511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           TGG+A  SY
Sbjct: 677 TGGMAFHSY 685
>NP_114160
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           TGG A RS+
Sbjct: 275 TGGAAGRSH 283
>NP_001073892
          Length = 1140

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GGIAARS 8
           GG+AARS
Sbjct: 178 GGLAARS 184
>XP_005254003
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           TGG A RS+
Sbjct: 276 TGGAAGRSH 284
>XP_005254002
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           TGG A RS+
Sbjct: 284 TGGAAGRSH 292
>XP_005272295
          Length = 961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TGGIAARS 8
           TGG +ARS
Sbjct: 120 TGGASARS 127
>NP_004651
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 592 SGGFGARDY 600
>NP_001116137
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 592 SGGFGARDY 600
>NP_001347
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 594 SGGFGARDY 602
>NP_001180346
          Length = 646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 578 SGGFGARDY 586
>NP_001180345
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 593 SGGFGARDY 601
>XP_006724941
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 569 SGGFGARDY 577
>XP_005262621
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 589 SGGFGARDY 597
>XP_006724940
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   TGGIAARSY 9
           +GG  AR Y
Sbjct: 592 SGGFGARDY 600
>NP_004930
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 325 GGVAAR 330
>NP_001075224
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 676 GGVAAR 681
>NP_001265844
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 701 GGVAAR 706
>NP_000492
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 695 GGVAAR 700
>NP_001265842
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 614 GGVAAR 619
>NP_001265846
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 685 GGVAAR 690
>NP_001265843
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 671 GGVAAR 676
>NP_001265868
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 757 GGVAAR 762
>NP_061722
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GGIAARS 8
           GGI ARS
Sbjct: 232 GGIPARS 238
>NP_001136099
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           +GG  ARSY
Sbjct: 328 SGGGPARSY 336
>NP_001136100
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           +GG  ARSY
Sbjct: 306 SGGGPARSY 314
>NP_060614
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGGIAARSY 9
           +GG  ARSY
Sbjct: 328 SGGGPARSY 336
>XP_006715941
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 527 GGVAAR 532
>XP_006715939
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 658 GGVAAR 663
>XP_006715937
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 677 GGVAAR 682
>XP_005250245
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 681 GGVAAR 686
>XP_005250244
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GGIAAR 7
           GG+AAR
Sbjct: 683 GGVAAR 688
>NP_114089
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GGIAARS 8
           GGI ARS
Sbjct: 232 GGIPARS 238
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.131    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,484
Number of extensions: 761
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package