Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001177984                                                           19     665
NP_689686                                                              19     665
NP_004295                                                              19     869
NP_036602                                                              17    4312
NP_001248385                                                           17    4312
NP_002339                                                              17    4312
NP_001248386                                                           17    4312
XP_006715974                                                           17    4312
XP_006711388                                                           17    4312
XP_006711387                                                           17    4312
XP_006711386                                                           17    4312
XP_006711385                                                           17    4312
XP_006711384                                                           17    4312
XP_006711383                                                           17    4312
XP_005245221                                                           17    4312
NP_001186028                                                           16    5631
NP_001186026                                                           16    5631
NP_001186027                                                           16    5631
NP_001186025                                                           16    5631
NP_003924                                                              16    5631
NP_001273393                                                           16    5631
NP_001935                                                              16    5631
NP_001136025                                                           16    7355
NP_001136024                                                           16    7355
NP_001165973                                                           16    7355
NP_009163                                                              16    7355
NP_443117                                                              16    7355
NP_689919                                                              16    7355
NP_542770                                                              16    7355
XP_006723759                                                           16    7355
XP_005260323                                                           16    7355
NP_444274                                                              16    7355
NP_001191314                                                           15    9605
NP_001020539                                                           15    9605
NP_001028928                                                           15    9605
NP_001165093                                                           15    9605
NP_001020537                                                           15    9605
NP_001020540                                                           15    9605
NP_001020541                                                           15    9605
NP_003367                                                              15    9605
NP_055365                                                              15    9605
NP_001020538                                                           15    9605
NP_001014811                                                           15    9605
NP_006671                                                              15    9605
NP_001155058                                                           15    9605
NP_733828                                                              15    9605
NP_001161807                                                           15    9605
NP_002387                                                              15    9605
NP_002386                                                              15    9605
NP_001171761                                                           15    9605
NP_000329                                                              15    9605
NP_644815                                                              15    9605
NP_006827                                                              15    9605
NP_851782                                                              15    9605
NP_055069                                                              15    9605
XP_005261155                                                           15    9605
XP_006723962                                                           15    9605
XP_006720719                                                           15    9605
XP_005254663                                                           15    9605
XP_005254662                                                           15    9605
XP_006719259                                                           15    9605
XP_005273774                                                           15    9605
XP_005251107                                                           15    9605
XP_005262782                                                           15    9605
XP_006714141                                                           15    9605
XP_005262780                                                           15    9605
XP_005262779                                                           15    9605
XP_006710170                                                           15    9605
>NP_001177984
          Length = 535

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TGE AVGLL
Sbjct: 293 TGECAVGLL 301
>NP_689686
          Length = 477

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TGE AVGLL
Sbjct: 293 TGECAVGLL 301
>NP_004295
          Length = 1620

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   GEAAVGLL 9
           GEAAVGLL
Sbjct: 159 GEAAVGLL 166
>NP_036602
          Length = 923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EAAVGLL 9
           EAAVGLL
Sbjct: 556 EAAVGLL 562
>NP_001248385
          Length = 641

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>NP_002339
          Length = 655

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>NP_001248386
          Length = 565

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_006715974
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EAAVGLL 9
           EAAVGLL
Sbjct: 508 EAAVGLL 514
>XP_006711388
          Length = 551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_006711387
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_006711386
          Length = 574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_006711385
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_006711384
          Length = 632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_006711383
          Length = 650

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>XP_005245221
          Length = 664

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TGEAAVGLL 9
           TGE  VG+L
Sbjct: 253 TGETVVGVL 261
>NP_001186028
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GEAAVGL 8
            GEAA+GL
Sbjct: 1053 GEAALGL 1059
>NP_001186026
          Length = 1152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GEAAVGL 8
            GEAA+GL
Sbjct: 1081 GEAALGL 1087
>NP_001186027
          Length = 1129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GEAAVGL 8
            GEAA+GL
Sbjct: 1058 GEAALGL 1064
>NP_001186025
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GEAAVGL 8
            GEAA+GL
Sbjct: 1045 GEAALGL 1051
>NP_003924
          Length = 1187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GEAAVGL 8
            GEAA+GL
Sbjct: 1116 GEAALGL 1122
>NP_001273393
          Length = 1169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GEAAVGL 8
            GEAA+GL
Sbjct: 1098 GEAALGL 1104
>NP_001935
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GEAAVGLL 9
           G AA+GLL
Sbjct: 617 GPAAIGLL 624
>NP_001136025
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TGEAAVGL 8
           TGE  VGL
Sbjct: 455 TGELGVGL 462
>NP_001136024
          Length = 1369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TGEAAVGL 8
           TGE  VGL
Sbjct: 455 TGELGVGL 462
>NP_001165973
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GEAAVGL 8
          GE AVGL
Sbjct: 11 GEVAVGL 17
>NP_009163
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GEAAVG 7
           GEAAVG
Sbjct: 278 GEAAVG 283
>NP_443117
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GEAAVGLL 9
           G AAVGLL
Sbjct: 581 GFAAVGLL 588
>NP_689919
          Length = 253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GEAAVGLL 9
          GEA  GLL
Sbjct: 82 GEAVTGLL 89
>NP_542770
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           +GEA+ GL+
Sbjct: 158 SGEASAGLM 166
>XP_006723759
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GEAAVG 7
           GEAAVG
Sbjct: 224 GEAAVG 229
>XP_005260323
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GEAAVG 7
           GEAAVG
Sbjct: 278 GEAAVG 283
>NP_444274
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           +GEA+ GL+
Sbjct: 158 SGEASAGLM 166
>NP_001191314
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001020539
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001028928
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001165093
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001020537
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001020540
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001020541
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_003367
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_055365
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 492 TGEAAV 497
>NP_001020538
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TGEAAV 6
           TGEAAV
Sbjct: 120 TGEAAV 125
>NP_001014811
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 338 GEAAMGI 344
>NP_006671
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 338 GEAAMGI 344
>NP_001155058
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 338 GEAAMGI 344
>NP_733828
          Length = 1322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TG++ VG+L
Sbjct: 286 TGDSQVGVL 294
>NP_001161807
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 313 GEAALGI 319
>NP_002387
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 313 GEAALGI 319
>NP_002386
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 303 GEAALGI 309
>NP_001171761
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GEAAVGL 8
           GEA +GL
Sbjct: 205 GEAGIGL 211
>NP_000329
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GEAAVGL 8
           GEA +GL
Sbjct: 205 GEAGIGL 211
>NP_644815
          Length = 85

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  GEAAVGL 8
          GE A+GL
Sbjct: 44 GEGAIGL 50
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EAAVGLL 9
           EAA+GLL
Sbjct: 856 EAALGLL 862
>NP_851782
          Length = 1283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TG++ VG+L
Sbjct: 262 TGDSQVGVL 270
>NP_055069
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           G+AA+GL
Sbjct: 104 GKAAIGL 110
>XP_005261155
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TGEAAVG 7
           TGE AVG
Sbjct: 299 TGEFAVG 305
>XP_006723962
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TGEAAVG 7
           TGE AVG
Sbjct: 299 TGEFAVG 305
>XP_006720719
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GEAAVGL 8
           GEA +GL
Sbjct: 205 GEAGIGL 211
>XP_005254663
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GEAAVGL 8
           GEA +GL
Sbjct: 205 GEAGIGL 211
>XP_005254662
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GEAAVGL 8
           GEA +GL
Sbjct: 205 GEAGIGL 211
>XP_006719259
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           G+AA+GL
Sbjct: 104 GKAAIGL 110
>XP_005273774
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEAAVGL 8
           GEAA+G+
Sbjct: 338 GEAAMGI 344
>XP_005251107
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GEAAVGL 8
           GE AVGL
Sbjct: 171 GEPAVGL 177
>XP_005262782
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TG++ VG+L
Sbjct: 188 TGDSQVGVL 196
>XP_006714141
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TG++ VG+L
Sbjct: 286 TGDSQVGVL 294
>XP_005262780
          Length = 1307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TG++ VG+L
Sbjct: 286 TGDSQVGVL 294
>XP_005262779
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TGEAAVGLL 9
           TG++ VG+L
Sbjct: 286 TGDSQVGVL 294
>XP_006710170
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TGEAAVG 7
           TGE AVG
Sbjct: 299 TGEFAVG 305
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.134    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 512,718
Number of extensions: 957
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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