Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     299
XP_005265476                                                           17    3301
NP_003232                                                              17    3301
NP_056127                                                              16    5631
NP_001241679                                                           16    5631
NP_001269105                                                           16    5631
NP_001269104                                                           16    5631
NP_006716                                                              16    5631
NP_001285                                                              16    5631
XP_006718801                                                           16    5631
XP_006714407                                                           16    5631
XP_006714406                                                           16    5631
XP_005263347                                                           16    5631
XP_005263346                                                           16    5631
XP_005263345                                                           16    5631
XP_005263344                                                           16    5631
XP_005263343                                                           16    5631
XP_005263342                                                           16    5631
XP_005263341                                                           16    5631
XP_005263340                                                           16    5631
XP_005263339                                                           16    5631
NP_066267                                                              16    7355
XP_006717852                                                           16    7355
XP_006717851                                                           16    7355
XP_006717850                                                           16    7355
XP_006717849                                                           16    7355
XP_006717848                                                           16    7355
XP_006717847                                                           16    7355
XP_006717846                                                           16    7355
XP_006717845                                                           16    7355
NP_000128                                                              15    9605
NP_000869                                                              15    9605
NP_000587                                                              15    9605
NP_001277131                                                           15    9605
NP_849191                                                              15    9605
NP_001092105                                                           15    9605
NP_671492                                                              15    9605
NP_001004065                                                           15    9605
NP_001185585                                                           15    9605
NP_036533                                                              15    9605
NP_009134                                                              15    9605
XP_005261968                                                           15    9605
XP_005261966                                                           15    9605
XP_005261967                                                           15    9605
XP_006724476                                                           15    9605
XP_005261965                                                           15    9605
NP_001130034                                                           15    9605
>NP_073713
          Length = 985

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TFYNSRQAV 9
          TFY+SRQAV
Sbjct: 90 TFYDSRQAV 98
>XP_005265476
          Length = 601

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FYNSRQAV 9
           +YN++QAV
Sbjct: 173 YYNTKQAV 180
>NP_003232
          Length = 684

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FYNSRQAV 9
           +YN++QAV
Sbjct: 256 YYNTKQAV 263
>NP_056127
          Length = 5005

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>NP_001241679
          Length = 601

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFYNSRQ 7
           TFYNS++
Sbjct: 469 TFYNSQR 475
>NP_001269105
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FYNSRQAV 9
           F+NSRQ++
Sbjct: 279 FWNSRQSL 286
>NP_001269104
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FYNSRQAV 9
           F+NSRQ++
Sbjct: 367 FWNSRQSL 374
>NP_006716
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFYNSRQ 7
           TFYNS++
Sbjct: 501 TFYNSQR 507
>NP_001285
          Length = 669

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FYNSRQAV 9
           F+NSRQ++
Sbjct: 381 FWNSRQSL 388
>XP_006718801
          Length = 636

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFYNSRQ 7
           TFYNS++
Sbjct: 469 TFYNSQR 475
>XP_006714407
          Length = 5004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_006714406
          Length = 3680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263347
          Length = 4640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263346
          Length = 4983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263345
          Length = 4991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263344
          Length = 5005

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263343
          Length = 5009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263342
          Length = 5025

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263341
          Length = 5026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263340
          Length = 5026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>XP_005263339
          Length = 5026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFYNSR 6
          T+YNSR
Sbjct: 45 TYYNSR 50
>NP_066267
          Length = 4377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3131 TFYTTRQ 3137
>XP_006717852
          Length = 3508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 2262 TFYTTRQ 2268
>XP_006717851
          Length = 3513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 2267 TFYTTRQ 2273
>XP_006717850
          Length = 4364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3118 TFYTTRQ 3124
>XP_006717849
          Length = 4383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3137 TFYTTRQ 3143
>XP_006717848
          Length = 4392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3146 TFYTTRQ 3152
>XP_006717847
          Length = 4395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3149 TFYTTRQ 3155
>XP_006717846
          Length = 4396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3150 TFYTTRQ 3156
>XP_006717845
          Length = 4397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TFYNSRQ 7
            TFY +RQ
Sbjct: 3151 TFYTTRQ 3157
>NP_000128
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FYNSRQ 7
           FY+SRQ
Sbjct: 127 FYSSRQ 132
>NP_000869
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  FYNSR 6
          FYNSR
Sbjct: 37 FYNSR 41
>NP_000587
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FYNSRQ 7
           FY+SRQ
Sbjct: 211 FYHSRQ 216
>NP_001277131
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYNSR 6
           FYNSR
Sbjct: 778 FYNSR 782
>NP_849191
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYNSR 6
           FYNSR
Sbjct: 903 FYNSR 907
>NP_001092105
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYNSR 6
           FYNSR
Sbjct: 903 FYNSR 907
>NP_671492
          Length = 1090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NSRQAV 9
           NSRQAV
Sbjct: 566 NSRQAV 571
>NP_001004065
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NSRQAV 9
           NSRQAV
Sbjct: 424 NSRQAV 429
>NP_001185585
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NSRQAV 9
           NSRQAV
Sbjct: 424 NSRQAV 429
>NP_036533
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYNSRQAV 9
           FY+ RQA+
Sbjct: 612 FYDCRQAM 619
>NP_009134
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NSRQAV 9
           NSRQAV
Sbjct: 566 NSRQAV 571
>XP_005261968
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYNSRQAV 9
           FY+ RQA+
Sbjct: 612 FYDCRQAM 619
>XP_005261966
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYNSRQAV 9
           FY+ RQA+
Sbjct: 612 FYDCRQAM 619
>XP_005261967
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYNSRQAV 9
           FY+ RQA+
Sbjct: 612 FYDCRQAM 619
>XP_006724476
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYNSRQAV 9
           FY+ RQA+
Sbjct: 612 FYDCRQAM 619
>XP_005261965
          Length = 1920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FYNSRQAV 9
           FY+ RQA+
Sbjct: 694 FYDCRQAM 701
>NP_001130034
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NSRQAV 9
           NSRQAV
Sbjct: 335 NSRQAV 340
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.125    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,738
Number of extensions: 370
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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