Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     509
NP_001263689                                                           20     509
NP_001119584                                                           20     509
NP_001119586                                                           20     509
NP_001263625                                                           20     509
NP_001119590                                                           20     509
NP_001263690                                                           20     509
NP_001119585                                                           20     509
NP_001263624                                                           20     509
NP_001119588                                                           20     509
NP_001119587                                                           20     509
NP_001119589                                                           20     509
NP_001263627                                                           20     509
NP_001263628                                                           20     509
NP_001263626                                                           20     509
NP_056493                                                              17    2528
XP_006719869                                                           17    2528
XP_006719868                                                           17    2528
XP_005266409                                                           17    2528
XP_005266408                                                           17    2528
XP_005266407                                                           17    2528
XP_005266403                                                           17    2528
XP_006719867                                                           17    2528
XP_006719866                                                           17    2528
XP_005266405                                                           17    2528
XP_005266404                                                           17    2528
NP_005850                                                              17    4312
NP_060043                                                              16    5631
XP_006722836                                                           16    5631
XP_006722835                                                           16    5631
XP_005259642                                                           16    5631
XP_006722834                                                           16    5631
XP_005259640                                                           16    5631
NP_005804                                                              16    7355
NP_001243239                                                           16    7355
NP_055720                                                              16    7355
NP_002733                                                              16    7355
NP_001073351                                                           16    7355
NP_001073350                                                           16    7355
NP_001073349                                                           16    7355
NP_057541                                                              16    7355
XP_005258773                                                           16    7355
XP_005267916                                                           16    7355
XP_005246524                                                           16    7355
XP_006712499                                                           16    7355
XP_006712498                                                           16    7355
XP_006712043                                                           16    7355
XP_006712042                                                           16    7355
XP_006712041                                                           16    7355
XP_005264295                                                           16    7355
XP_005264294                                                           16    7355
NP_009052                                                              15    9605
NP_056112                                                              15    9605
NP_443109                                                              15    9605
NP_000520                                                              15    9605
NP_963836                                                              15    9605
XP_005251477                                                           15    9605
>NP_000537
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001263689
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119584
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001119586
          Length = 341

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001263625
          Length = 302

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119590
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001263690
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119585
          Length = 346

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001263624
          Length = 307

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           TFR SVVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119588
          Length = 209

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRRSVVVP 9
          TFR SVVVP
Sbjct: 79 TFRHSVVVP 87
>NP_001119587
          Length = 261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRRSVVVP 9
          TFR SVVVP
Sbjct: 79 TFRHSVVVP 87
>NP_001119589
          Length = 214

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRRSVVVP 9
          TFR SVVVP
Sbjct: 79 TFRHSVVVP 87
>NP_001263627
          Length = 182

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRRSVVVP 9
          TFR SVVVP
Sbjct: 52 TFRHSVVVP 60
>NP_001263628
          Length = 187

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRRSVVVP 9
          TFR SVVVP
Sbjct: 52 TFRHSVVVP 60
>NP_001263626
          Length = 234

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRRSVVVP 9
          TFR SVVVP
Sbjct: 52 TFRHSVVVP 60
>NP_056493
          Length = 2946

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1786 SFDRSVVVP 1794
>XP_006719869
          Length = 2943

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1783 SFDRSVVVP 1791
>XP_006719868
          Length = 2938

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1783 SFDRSVVVP 1791
>XP_005266409
          Length = 1430

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TFRRSVVVP 9
           +F RSVVVP
Sbjct: 249 SFDRSVVVP 257
>XP_005266408
          Length = 1934

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1786 SFDRSVVVP 1794
>XP_005266407
          Length = 2641

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1460 SFDRSVVVP 1468
>XP_005266403
          Length = 2941

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1786 SFDRSVVVP 1794
>XP_006719867
          Length = 2961

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1786 SFDRSVVVP 1794
>XP_006719866
          Length = 2962

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1786 SFDRSVVVP 1794
>XP_005266405
          Length = 2964

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1783 SFDRSVVVP 1791
>XP_005266404
          Length = 2967

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TFRRSVVVP 9
            +F RSVVVP
Sbjct: 1786 SFDRSVVVP 1794
>NP_005850
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRRSVVVP 9
           T+R S+ VP
Sbjct: 252 TYRNSITVP 260
>NP_060043
          Length = 755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRSVVVP 9
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006722836
          Length = 510

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRSVVVP 9
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006722835
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRSVVVP 9
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_005259642
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRSVVVP 9
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_006722834
          Length = 697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRSVVVP 9
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>XP_005259640
          Length = 746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RRSVVVP 9
           +RSVVVP
Sbjct: 112 KRSVVVP 118
>NP_005804
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 731 SFRRSVV 737
>NP_001243239
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRRSVVVP 9
           FRR  V+P
Sbjct: 215 FRRKFVIP 222
>NP_055720
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRRSVVVP 9
           FRR  V+P
Sbjct: 215 FRRKFVIP 222
>NP_002733
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 738 SFRRSVV 744
>NP_001073351
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 549 SFRRSVV 555
>NP_001073350
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_001073349
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_057541
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>XP_005258773
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 549 SFRRSVV 555
>XP_005267916
          Length = 920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 746 SFRRSVV 752
>XP_005246524
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRRSVVVP 9
           FRR  V+P
Sbjct: 215 FRRKFVIP 222
>XP_006712499
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRRSVVVP 9
           FRR  V+P
Sbjct: 215 FRRKFVIP 222
>XP_006712498
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRRSVVVP 9
           FRR  V+P
Sbjct: 215 FRRKFVIP 222
>XP_006712043
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 472 SFRRSVV 478
>XP_006712042
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 558 SFRRSVV 564
>XP_006712041
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 558 SFRRSVV 564
>XP_005264295
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 627 SFRRSVV 633
>XP_005264294
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TFRRSVV 7
           +FRRSVV
Sbjct: 731 SFRRSVV 737
>NP_009052
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   FRRSVV 7
           FRRSVV
Sbjct: 111 FRRSVV 116
>NP_056112
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRRSVVVP 9
           TF+R  V+P
Sbjct: 206 TFQRCKVIP 214
>NP_443109
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  FRRSVVVP 9
          FR  V++P
Sbjct: 71 FRNQVIIP 78
>NP_000520
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TFRRSVVV 8
           T RR+VVV
Sbjct: 143 TMRRTVVV 150
>NP_963836
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  FRRSVVVP 9
          FR  V++P
Sbjct: 71 FRNQVIIP 78
>XP_005251477
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRRSVVVP 9
           TF+R  V+P
Sbjct: 206 TFQRCKVIP 214
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.142    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 397,228
Number of extensions: 523
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package