Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     299
NP_001263689                                                           20     299
NP_001119584                                                           20     299
NP_001119586                                                           20     299
NP_001263625                                                           20     299
NP_001119590                                                           20     299
NP_001263690                                                           20     299
NP_001119585                                                           20     299
NP_001263624                                                           20     299
NP_001119588                                                           20     299
NP_001119587                                                           20     299
NP_001119589                                                           20     299
NP_001263627                                                           20     299
NP_001263628                                                           20     299
NP_001263626                                                           20     299
NP_001091884                                                           17    4312
NP_940886                                                              17    4312
XP_005265137                                                           17    4312
XP_006713177                                                           17    4312
XP_005265136                                                           17    4312
XP_005258399                                                           16    5631
NP_000825                                                              16    7355
NP_001164982                                                           16    7355
NP_001161846                                                           16    7355
NP_001161849                                                           16    7355
NP_001161848                                                           16    7355
NP_001239257                                                           16    7355
NP_055624                                                              16    7355
NP_001161847                                                           16    7355
XP_006715351                                                           16    7355
XP_006715350                                                           16    7355
XP_006715349                                                           16    7355
XP_005249561                                                           16    7355
NP_001107854                                                           15    9605
NP_001121636                                                           15    9605
NP_000323                                                              15    9605
NP_001070651                                                           15    9605
NP_000539                                                              15    9605
NP_063968                                                              15    9605
NP_001112                                                              15    9605
NP_058432                                                              15    9605
NP_001186978                                                           15    9605
NP_000732                                                              15    9605
NP_001121902                                                           15    9605
NP_001121901                                                           15    9605
NP_644807                                                              15    9605
NP_005579                                                              15    9605
NP_064544                                                              15    9605
NP_001361                                                              15    9605
NP_001241878                                                           15    9605
XP_005255589                                                           15    9605
XP_005255588                                                           15    9605
XP_005255587                                                           15    9605
XP_005255586                                                           15    9605
XP_005255585                                                           15    9605
XP_005255584                                                           15    9605
XP_005254927                                                           15    9605
XP_005269592                                                           15    9605
XP_006717692                                                           15    9605
XP_006717691                                                           15    9605
XP_005269591                                                           15    9605
XP_006717690                                                           15    9605
XP_005269590                                                           15    9605
XP_006717689                                                           15    9605
XP_005269588                                                           15    9605
XP_005269587                                                           15    9605
XP_005269586                                                           15    9605
XP_006714339                                                           15    9605
XP_006714338                                                           15    9605
XP_006712019                                                           15    9605
NP_694585                                                              15    9605
>NP_000537
          Length = 393

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001263689
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119584
          Length = 393

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001119586
          Length = 341

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001263625
          Length = 302

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119590
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001263690
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119585
          Length = 346

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 211 TFRHSVVVP 219
>NP_001263624
          Length = 307

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFRHIVVVP 9
           TFRH VVVP
Sbjct: 172 TFRHSVVVP 180
>NP_001119588
          Length = 209

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRHIVVVP 9
          TFRH VVVP
Sbjct: 79 TFRHSVVVP 87
>NP_001119587
          Length = 261

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRHIVVVP 9
          TFRH VVVP
Sbjct: 79 TFRHSVVVP 87
>NP_001119589
          Length = 214

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRHIVVVP 9
          TFRH VVVP
Sbjct: 79 TFRHSVVVP 87
>NP_001263627
          Length = 182

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRHIVVVP 9
          TFRH VVVP
Sbjct: 52 TFRHSVVVP 60
>NP_001263628
          Length = 187

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRHIVVVP 9
          TFRH VVVP
Sbjct: 52 TFRHSVVVP 60
>NP_001263626
          Length = 234

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TFRHIVVVP 9
          TFRH VVVP
Sbjct: 52 TFRHSVVVP 60
>NP_001091884
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRHIVVVP 9
           TF H V++P
Sbjct: 385 TFPHAVLIP 393
>NP_940886
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRHIVVVP 9
           TF H V++P
Sbjct: 385 TFPHAVLIP 393
>XP_005265137
          Length = 404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRHIVVVP 9
           TF H V++P
Sbjct: 350 TFPHAVLIP 358
>XP_006713177
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRHIVVVP 9
           TF H V++P
Sbjct: 377 TFPHAVLIP 385
>XP_005265136
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TFRHIVVVP 9
           TF H V++P
Sbjct: 377 TFPHAVLIP 385
>XP_005258399
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TFRHIVVVP 9
           + RH V++P
Sbjct: 185 SLRHCVIIP 193
>NP_000825
          Length = 1484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  FRHIVVVP 9
          F H+ VVP
Sbjct: 59 FHHLSVVP 66
>NP_001164982
          Length = 127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TFRHIV 6
          TFRHI+
Sbjct: 29 TFRHIM 34
>NP_001161846
          Length = 1063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 717 RHVLVLP 723
>NP_001161849
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 726 RHVLVLP 732
>NP_001161848
          Length = 1027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 681 RHVLVLP 687
>NP_001239257
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 137 RHVLVLP 143
>NP_055624
          Length = 1072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 726 RHVLVLP 732
>NP_001161847
          Length = 1072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 726 RHVLVLP 732
>XP_006715351
          Length = 920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 574 RHVLVLP 580
>XP_006715350
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 788 RHVLVLP 794
>XP_006715349
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 755 RHVLVLP 761
>XP_005249561
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RHIVVVP 9
           RH++V+P
Sbjct: 788 RHVLVLP 794
>NP_001107854
          Length = 1784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1645 FVHVIVTP 1652
>NP_001121636
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RHIVVVP 9
           RH+VV P
Sbjct: 359 RHVVVHP 365
>NP_000323
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RHIVVVP 9
           RH+VV P
Sbjct: 359 RHVVVHP 365
>NP_001070651
          Length = 1740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1601 FVHVIVTP 1608
>NP_000539
          Length = 1807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1668 FVHVIVTP 1675
>NP_063968
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>NP_001112
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>NP_058432
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>NP_001186978
          Length = 2715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    FRHIVVV 8
            F+H+V+V
Sbjct: 1151 FKHMVIV 1157
>NP_000732
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TFRHIVV 7
           TFRH+++
Sbjct: 463 TFRHLLL 469
>NP_001121902
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           H++VVP
Sbjct: 548 HLIVVP 553
>NP_001121901
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           H++VVP
Sbjct: 548 HLIVVP 553
>NP_644807
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRHIVV 7
           +RHIVV
Sbjct: 539 YRHIVV 544
>NP_005579
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2  FRHIVVVP 9
          F HI  VP
Sbjct: 16 FAHIAAVP 23
>NP_064544
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           H++VVP
Sbjct: 548 HLIVVP 553
>NP_001361
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  TFRHI 5
          TFRHI
Sbjct: 52 TFRHI 56
>NP_001241878
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           H++VVP
Sbjct: 118 HLIVVP 123
>XP_005255589
          Length = 1831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1692 FVHVIVTP 1699
>XP_005255588
          Length = 1832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1693 FVHVIVTP 1700
>XP_005255587
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1715 FVHVIVTP 1722
>XP_005255586
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1716 FVHVIVTP 1723
>XP_005255585
          Length = 1875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1736 FVHVIVTP 1743
>XP_005255584
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    FRHIVVVP 9
            F H++V P
Sbjct: 1759 FVHVIVTP 1766
>XP_005254927
          Length = 165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   TFRHIVV 7
           TF H+V+
Sbjct: 118 TFNHLVI 124
>XP_005269592
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4  HIVVVP 9
          HI+++P
Sbjct: 93 HIIIIP 98
>XP_006717692
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4  HIVVVP 9
          HI+++P
Sbjct: 93 HIIIIP 98
>XP_006717691
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_005269591
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_006717690
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_005269590
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_006717689
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_005269588
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_005269587
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_005269586
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           HI+++P
Sbjct: 171 HIIIIP 176
>XP_006714339
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           H++VVP
Sbjct: 315 HLIVVP 320
>XP_006714338
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HIVVVP 9
           H++VVP
Sbjct: 518 HLIVVP 523
>XP_006712019
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  TFRHI 5
          TFRHI
Sbjct: 52 TFRHI 56
>NP_694585
          Length = 178

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   TFRHIVV 7
           TF H+V+
Sbjct: 118 TFNHLVI 124
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.153    0.499 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 563,217
Number of extensions: 985
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package