Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     299
NP_001008938                                                           17    4312
NP_004727                                                              16    5631
NP_001129141                                                           16    5631
NP_001004725                                                           16    5631
NP_056112                                                              16    7355
NP_001171596                                                           16    7355
NP_001012770                                                           16    7355
NP_001012768                                                           16    7355
NP_001171593                                                           16    7355
NP_001171595                                                           16    7355
NP_005461                                                              16    7355
NP_001171594                                                           16    7355
NP_001171591                                                           16    7355
NP_001171587                                                           16    7355
NP_001012769                                                           16    7355
NP_001171592                                                           16    7355
NP_001171590                                                           16    7355
XP_006717424                                                           16    7355
XP_005252390                                                           16    7355
XP_006717423                                                           16    7355
XP_005252389                                                           16    7355
XP_006717422                                                           16    7355
XP_005251477                                                           16    7355
NP_005041                                                              15    9605
NP_898871                                                              15    9605
NP_000047                                                              15    9605
NP_996769                                                              15    9605
NP_060390                                                              15    9605
NP_001071131                                                           15    9605
NP_001277005                                                           15    9605
NP_001277004                                                           15    9605
NP_001071132                                                           15    9605
NP_001161052                                                           15    9605
NP_055663                                                              15    9605
NP_001171070                                                           15    9605
NP_001135419                                                           15    9605
NP_055797                                                              15    9605
NP_001012524                                                           15    9605
XP_005255055                                                           15    9605
XP_005255054                                                           15    9605
XP_005267995                                                           15    9605
XP_005267993                                                           15    9605
XP_005267486                                                           15    9605
XP_006720145                                                           15    9605
XP_005267485                                                           15    9605
XP_005267484                                                           15    9605
XP_005267483                                                           15    9605
XP_005267482                                                           15    9605
XP_005267481                                                           15    9605
XP_005267480                                                           15    9605
XP_005267479                                                           15    9605
XP_005267478                                                           15    9605
XP_005267477                                                           15    9605
XP_006715605                                                           15    9605
XP_005248813                                                           15    9605
XP_005265144                                                           15    9605
XP_005265141                                                           15    9605
XP_005265140                                                           15    9605
XP_006713178                                                           15    9605
XP_005265139                                                           15    9605
XP_005265138                                                           15    9605
XP_005273106                                                           15    9605
XP_005273105                                                           15    9605
XP_005273104                                                           15    9605
XP_005273103                                                           15    9605
XP_006711225                                                           15    9605
XP_006710675                                                           15    9605
XP_006710674                                                           15    9605
XP_006710673                                                           15    9605
XP_006710672                                                           15    9605
NP_620149                                                              15    9605
>NP_004351
          Length = 882

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TFMEQKIIY 9
           TFMEQKI Y
Sbjct: 515 TFMEQKITY 523
>NP_001008938
          Length = 2032

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TFMEQKIIY 9
            TFM+ ++IY
Sbjct: 1588 TFMQLRLIY 1596
>NP_004727
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TFMEQKIIY 9
           TF+ ++I+Y
Sbjct: 545 TFLREEIVY 553
>NP_001129141
          Length = 631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TFMEQKIIY 9
           TF+ ++I+Y
Sbjct: 480 TFLREEIVY 488
>NP_001004725
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TFMEQKII 8
          TF+E KII
Sbjct: 83 TFVEHKII 90
>NP_056112
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   TFMEQKIIY 9
           TF+++ ++Y
Sbjct: 375 TFLQENVLY 383
>NP_001171596
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 287 SFMEGAIIY 295
>NP_001012770
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 434 SFMEGAIIY 442
>NP_001012768
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 439 SFMEGAIIY 447
>NP_001171593
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 380 SFMEGAIIY 388
>NP_001171595
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 346 SFMEGAIIY 354
>NP_005461
          Length = 508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 466 SFMEGAIIY 474
>NP_001171594
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 351 SFMEGAIIY 359
>NP_001171591
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 409 SFMEGAIIY 417
>NP_001171587
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 454 SFMEGAIIY 462
>NP_001012769
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 410 SFMEGAIIY 418
>NP_001171592
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 404 SFMEGAIIY 412
>NP_001171590
          Length = 480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 438 SFMEGAIIY 446
>XP_006717424
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 405 SFMEGAIIY 413
>XP_005252390
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 433 SFMEGAIIY 441
>XP_006717423
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 437 SFMEGAIIY 445
>XP_005252389
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 461 SFMEGAIIY 469
>XP_006717422
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           +FME  IIY
Sbjct: 465 SFMEGAIIY 473
>XP_005251477
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   TFMEQKIIY 9
           TF+++ ++Y
Sbjct: 375 TFLQENVLY 383
>NP_005041
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TFMEQKIIY 9
          T +EQ +IY
Sbjct: 50 TLLEQFVIY 58
>NP_898871
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FMEQKIIY 9
           F E KI+Y
Sbjct: 237 FFEPKILY 244
>NP_000047
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FMEQKIIY 9
           F E KI+Y
Sbjct: 237 FFEPKILY 244
>NP_996769
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    MEQKII 8
            MEQKII
Sbjct: 1042 MEQKII 1047
>NP_060390
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           ME++IIY
Sbjct: 142 MEEEIIY 148
>NP_001071131
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           ME++IIY
Sbjct: 151 MEEEIIY 157
>NP_001277005
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           ME++IIY
Sbjct: 108 MEEEIIY 114
>NP_001277004
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           ME++IIY
Sbjct: 108 MEEEIIY 114
>NP_001071132
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           ME++IIY
Sbjct: 108 MEEEIIY 114
>NP_001161052
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TFMEQK 6
           TF+EQK
Sbjct: 367 TFLEQK 372
>NP_055663
          Length = 683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TFMEQK 6
           TF+EQK
Sbjct: 518 TFLEQK 523
>NP_001171070
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TFMEQKIIY 9
           TFME+K  Y
Sbjct: 396 TFMEKKGSY 404
>NP_001135419
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 348 IEEKIIY 354
>NP_055797
          Length = 2341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1356 FVEKNIIY 1363
>NP_001012524
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 314 IEEKIIY 320
>XP_005255055
          Length = 683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TFMEQK 6
           TF+EQK
Sbjct: 518 TFLEQK 523
>XP_005255054
          Length = 683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TFMEQK 6
           TF+EQK
Sbjct: 518 TFLEQK 523
>XP_005267995
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TFMEQKIIY 9
          T +EQ +IY
Sbjct: 50 TLLEQFVIY 58
>XP_005267993
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TFMEQKIIY 9
          T +EQ +IY
Sbjct: 50 TLLEQFVIY 58
>XP_005267486
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FMEQKIIY 9
           F+E+ IIY
Sbjct: 436 FVEKNIIY 443
>XP_006720145
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FMEQKIIY 9
           F+E+ IIY
Sbjct: 438 FVEKNIIY 445
>XP_005267485
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FMEQKIIY 9
           F+E+ IIY
Sbjct: 474 FVEKNIIY 481
>XP_005267484
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1364 FVEKNIIY 1371
>XP_005267483
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1245 FVEKNIIY 1252
>XP_005267482
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1258 FVEKNIIY 1265
>XP_005267481
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1308 FVEKNIIY 1315
>XP_005267480
          Length = 2336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1351 FVEKNIIY 1358
>XP_005267479
          Length = 2344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1359 FVEKNIIY 1366
>XP_005267478
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1363 FVEKNIIY 1370
>XP_005267477
          Length = 2349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FMEQKIIY 9
            F+E+ IIY
Sbjct: 1364 FVEKNIIY 1371
>XP_006715605
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FMEQKIIY 9
           F E KI+Y
Sbjct: 167 FFEPKILY 174
>XP_005248813
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FMEQKIIY 9
           F E KI+Y
Sbjct: 237 FFEPKILY 244
>XP_005265144
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 348 IEEKIIY 354
>XP_005265141
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MEQKIIY 9
          +E+KIIY
Sbjct: 49 IEEKIIY 55
>XP_005265140
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 348 IEEKIIY 354
>XP_006713178
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 338 IEEKIIY 344
>XP_005265139
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 341 IEEKIIY 347
>XP_005265138
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MEQKIIY 9
           +E+KIIY
Sbjct: 348 IEEKIIY 354
>XP_005273106
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TFMEQKIIY 9
          TF   KIIY
Sbjct: 12 TFQHIKIIY 20
>XP_005273105
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TFMEQKIIY 9
          TF   KIIY
Sbjct: 12 TFQHIKIIY 20
>XP_005273104
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TFMEQKIIY 9
          TF   KIIY
Sbjct: 12 TFQHIKIIY 20
>XP_005273103
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TFMEQKIIY 9
          TF   KIIY
Sbjct: 50 TFQHIKIIY 58
>XP_006711225
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TFMEQKIIY 9
          TF   KIIY
Sbjct: 50 TFQHIKIIY 58
>XP_006710675
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   MEQKII 8
           MEQKII
Sbjct: 370 MEQKII 375
>XP_006710674
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   MEQKII 8
           MEQKII
Sbjct: 721 MEQKII 726
>XP_006710673
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    MEQKII 8
            MEQKII
Sbjct: 1150 MEQKII 1155
>XP_006710672
          Length = 1563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    MEQKII 8
            MEQKII
Sbjct: 1150 MEQKII 1155
>NP_620149
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TFMEQKIIY 9
          TF   KIIY
Sbjct: 50 TFQHIKIIY 58
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.144    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 459,119
Number of extensions: 626
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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