Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_536858                                                              17    4312
NP_002822                                                              17    4312
NP_536859                                                              17    4312
XP_006719057                                                           17    4312
NP_001360                                                              16    5631
XP_005248319                                                           16    5631
NP_689644                                                              16    5631
NP_001245135                                                           16    7355
NP_001245136                                                           16    7355
NP_005419                                                              16    7355
XP_005259699                                                           16    7355
NP_004374                                                              15    9605
NP_001120662                                                           15    9605
NP_002652                                                              15    9605
NP_852664                                                              15    9605
NP_852556                                                              15    9605
NP_005408                                                              15    9605
NP_938033                                                              15    9605
NP_852665                                                              15    9605
NP_001229395                                                           15    9605
XP_005254222                                                           15    9605
XP_005248599                                                           15    9605

>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TFIVRQSIN 9
            TFIVRQSI+
Sbjct: 1558 TFIVRQSIH 1566



>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TFIVRQSIN 9
            TFIVRQSI+
Sbjct: 1558 TFIVRQSIH 1566



>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TFIVRQSIN 9
            TFIVRQSI+
Sbjct: 1558 TFIVRQSIH 1566



>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TFIVRQSIN 9
            TFIVRQSI+
Sbjct: 1558 TFIVRQSIH 1566



>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TFIVRQSIN 9
            TFIVRQSI+
Sbjct: 1558 TFIVRQSIH 1566



>NP_536858
          Length = 597

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TFIVRQSIN 9
           TF+VR+S++
Sbjct: 134 TFLVRESLS 142



>NP_002822
          Length = 595

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TFIVRQSIN 9
           TF+VR+S++
Sbjct: 132 TFLVRESLS 140



>NP_536859
          Length = 624

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TFIVRQSIN 9
           TF+VR+S++
Sbjct: 132 TFLVRESLS 140



>XP_006719057
          Length = 481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TFIVRQSIN 9
          TF+VR+S++
Sbjct: 18 TFLVRESLS 26



>NP_001360
          Length = 4624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FIVRQSIN 9
            F++ QSIN
Sbjct: 2453 FVITQSIN 2460



>XP_005248319
          Length = 4609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FIVRQSIN 9
            F++ QSIN
Sbjct: 2438 FVITQSIN 2445



>NP_689644
          Length = 852

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TFIVRQSIN 9
           TF+V QSI+
Sbjct: 830 TFLVAQSIH 838



>NP_001245135
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TFIVRQSI 8
           TF+VRQ +
Sbjct: 670 TFLVRQRV 677



>NP_001245136
          Length = 813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TFIVRQSI 8
           TF+VRQ +
Sbjct: 660 TFLVRQRV 667



>NP_005419
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TFIVRQSI 8
           TF+VRQ +
Sbjct: 692 TFLVRQRV 699



>XP_005259699
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TFIVRQSI 8
           TF+VRQ +
Sbjct: 692 TFLVRQRV 699



>NP_004374
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FIVRQSIN 9
           F+VR+S N
Sbjct: 104 FLVRESTN 111



>NP_001120662
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FIVRQSIN 9
           F+VR+S N
Sbjct: 104 FLVRESTN 111



>NP_002652
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 560 TFLVRES 566



>NP_852664
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 645 TFLVRES 651



>NP_852556
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 375 TFLVRES 381



>NP_005408
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 174 TFLVRES 180



>NP_938033
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 174 TFLVRES 180



>NP_852665
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 345 TFLVRES 351



>NP_001229395
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 282 TFLVRES 288



>XP_005254222
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FIVRQSIN 9
           F+VR+S N
Sbjct: 104 FLVRESTN 111



>XP_005248599
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TFIVRQS 7
           TF+VR+S
Sbjct: 645 TFLVRES 651



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.140    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 287,895
Number of extensions: 406
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)