Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              19     665
NP_001087241                                                           19     665
XP_005265799                                                           19     665
XP_005265798                                                           19     665
XP_005265797                                                           19     665
NP_004110                                                              18    1935
NP_002966                                                              17    4312
NP_005202                                                              16    5631
NP_001275634                                                           16    5631
NP_702918                                                              16    5631
NP_702915                                                              16    5631
NP_702911                                                              16    5631
NP_001229282                                                           16    5631
NP_001229281                                                           16    5631
NP_001229283                                                           16    5631
NP_002531                                                              16    5631
NP_702914                                                              16    5631
NP_702913                                                              16    5631
NP_702910                                                              16    5631
NP_702917                                                              16    5631
XP_006717191                                                           16    5631
XP_006717190                                                           16    5631
XP_005252086                                                           16    5631
XP_005252085                                                           16    5631
XP_006717189                                                           16    5631
XP_006717188                                                           16    5631
XP_005252084                                                           16    5631
XP_005252083                                                           16    5631
XP_005252082                                                           16    5631
XP_006717187                                                           16    5631
XP_005252081                                                           16    5631
XP_005252080                                                           16    5631
XP_005252079                                                           16    5631
XP_005252078                                                           16    5631
XP_006717186                                                           16    5631
XP_005252077                                                           16    5631
XP_005252075                                                           16    5631
XP_005252076                                                           16    5631
XP_005252074                                                           16    5631
XP_005252073                                                           16    5631
XP_006717185                                                           16    5631
XP_005252072                                                           16    5631
XP_005252071                                                           16    5631
XP_005252070                                                           16    5631
XP_005252069                                                           16    5631
XP_005252068                                                           16    5631
XP_005252067                                                           16    5631
XP_005265526                                                           16    5631
XP_005265525                                                           16    5631
XP_005265517                                                           16    5631
XP_005265515                                                           16    5631
XP_005265514                                                           16    5631
XP_005265513                                                           16    5631
NP_001073883                                                           16    7355
XP_005267749                                                           16    7355
XP_005267748                                                           16    7355
NP_659462                                                              15    9605
NP_001138600                                                           15    9605
XP_006715439                                                           15    9605
>NP_000213
          Length = 976

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TEREALMSK 9
           TEREALMS+
Sbjct: 632 TEREALMSE 640
>NP_001087241
          Length = 972

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TEREALMSK 9
           TEREALMS+
Sbjct: 628 TEREALMSE 636
>XP_005265799
          Length = 973

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TEREALMSK 9
           TEREALMS+
Sbjct: 629 TEREALMSE 637
>XP_005265798
          Length = 976

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TEREALMSK 9
           TEREALMS+
Sbjct: 633 TEREALMSE 641
>XP_005265797
          Length = 977

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TEREALMSK 9
           TEREALMS+
Sbjct: 633 TEREALMSE 641
>NP_004110
          Length = 993

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   TEREALMSK 9
           +EREALMS+
Sbjct: 653 SEREALMSE 661
>NP_002966
          Length = 323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EREALMSK 9
          EREALM K
Sbjct: 42 EREALMLK 49
>NP_005202
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EREALMSK 9
           E+EALMS+
Sbjct: 626 EKEALMSE 633
>NP_001275634
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EREALMSK 9
           E+EALMS+
Sbjct: 626 EKEALMSE 633
>NP_702918
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>NP_702915
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>NP_702911
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>NP_001229282
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>NP_001229281
          Length = 824

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 198 EKECLMSK 205
>NP_001229283
          Length = 576

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 122 EKECLMSK 129
>NP_002531
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 179 EKECLMSK 186
>NP_702914
          Length = 657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>NP_702913
          Length = 893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 267 EKECLMSK 274
>NP_702910
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 247 EKECLMSK 254
>NP_702917
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 228 EKECLMSK 235
>XP_006717191
          Length = 657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_006717190
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 179 EKECLMSK 186
>XP_005252086
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>XP_005252085
          Length = 819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 141 EKECLMSK 148
>XP_006717189
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_006717188
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 228 EKECLMSK 235
>XP_005252084
          Length = 857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 179 EKECLMSK 186
>XP_005252083
          Length = 857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 179 EKECLMSK 186
>XP_005252082
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>XP_006717187
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>XP_005252081
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>XP_005252080
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>XP_005252079
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 184 EKECLMSK 191
>XP_005252078
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 190 EKECLMSK 197
>XP_006717186
          Length = 873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 247 EKECLMSK 254
>XP_005252077
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 198 EKECLMSK 205
>XP_005252075
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 198 EKECLMSK 205
>XP_005252076
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 198 EKECLMSK 205
>XP_005252074
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 198 EKECLMSK 205
>XP_005252073
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_006717185
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_005252072
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_005252071
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_005252070
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_005252069
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 203 EKECLMSK 210
>XP_005252068
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 228 EKECLMSK 235
>XP_005252067
          Length = 925

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EREALMSK 9
           E+E LMSK
Sbjct: 247 EKECLMSK 254
>XP_005265526
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TEREALMSK 9
           TE+E L+SK
Sbjct: 412 TEKEHLLSK 420
>XP_005265525
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TEREALMSK 9
           TE+E L+SK
Sbjct: 412 TEKEHLLSK 420
>XP_005265517
          Length = 830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TEREALMSK 9
           TE+E L+SK
Sbjct: 395 TEKEHLLSK 403
>XP_005265515
          Length = 844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TEREALMSK 9
           TE+E L+SK
Sbjct: 412 TEKEHLLSK 420
>XP_005265514
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TEREALMSK 9
           TE+E L+SK
Sbjct: 410 TEKEHLLSK 418
>XP_005265513
          Length = 847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TEREALMSK 9
           TE+E L+SK
Sbjct: 412 TEKEHLLSK 420
>NP_001073883
          Length = 2028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TEREALMSK 9
            TEREAL  +
Sbjct: 1232 TEREALQQE 1240
>XP_005267749
          Length = 1055

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TEREALMSK 9
           TEREAL  +
Sbjct: 259 TEREALQQE 267
>XP_005267748
          Length = 1535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TEREALMSK 9
            TEREAL  +
Sbjct: 1232 TEREALQQE 1240
>NP_659462
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TEREALMSK 9
          TER  L+SK
Sbjct: 21 TERNFLLSK 29
>NP_001138600
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TEREALMSK 9
          TER  L+SK
Sbjct: 21 TERNFLLSK 29
>XP_006715439
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TEREALMSK 9
          TER  L+SK
Sbjct: 21 TERNFLLSK 29
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.109    0.246 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 340,885
Number of extensions: 403
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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