Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_006726410                                                           20     509
XP_006711164                                                           20     509
NP_001185761                                                           19     869
NP_071754                                                              19     869
NP_001185763                                                           19     869
NP_001002810                                                           19     869
NP_055459                                                              19     869
NP_001182189                                                           19     869
NP_001002812                                                           19     869
NP_001182190                                                           19     869
XP_006711719                                                           19     869
XP_006711717                                                           19     869
XP_006711716                                                           19     869
XP_006711715                                                           19     869
XP_006711714                                                           19     869
XP_006711713                                                           19     869
XP_006711710                                                           19     869
XP_006711709                                                           19     869
XP_006726402                                                           18    1135
XP_006711153                                                           18    1135
XP_005246376                                                           17    2528
NP_001248339                                                           17    3301
NP_003558                                                              17    3301
NP_001248337                                                           17    3301
NP_001248338                                                           17    3301
NP_570899                                                              17    4312
NP_443161                                                              17    4312
XP_006718835                                                           17    4312
XP_005273858                                                           17    4312
XP_005273857                                                           17    4312
XP_006718834                                                           17    4312
XP_005273855                                                           17    4312
XP_006710380                                                           17    4312
XP_005245788                                                           17    4312
XP_006710379                                                           17    4312
XP_006710378                                                           17    4312
NP_149055                                                              16    7355
XP_005246793                                                           16    7355
XP_005246792                                                           16    7355
XP_005246791                                                           16    7355
XP_005246790                                                           16    7355
XP_005246789                                                           16    7355
XP_006710802                                                           16    7355
NP_001207705                                                           15    9605
NP_001207703                                                           15    9605
NP_001207696                                                           15    9605
NP_001207699                                                           15    9605
NP_997237                                                              15    9605
NP_071926                                                              15    9605
NP_062535                                                              15    9605
NP_877435                                                              15    9605
NP_001138998                                                           15    9605
NP_001010982                                                           15    9605
XP_006721763                                                           15    9605
XP_006721762                                                           15    9605
XP_006721761                                                           15    9605
XP_006721760                                                           15    9605
XP_006721759                                                           15    9605
XP_005267917                                                           15    9605
XP_006718594                                                           15    9605
XP_005268557                                                           15    9605
XP_006714856                                                           15    9605
XP_005268556                                                           15    9605
XP_006714855                                                           15    9605
XP_006714854                                                           15    9605
XP_005268555                                                           15    9605
XP_005268554                                                           15    9605
NP_006625                                                              15    9605
>XP_006726410
          Length = 2087

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 240 TETLAQRDK 248
>XP_006711164
          Length = 2087

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 240 TETLAQRDK 248
>NP_001185761
          Length = 2240

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 231 TEALAQRDK 239
>NP_071754
          Length = 310

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 302 TEALAQRDK 310
>NP_001185763
          Length = 2362

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 165 TEALAQRDK 173
>NP_001002810
          Length = 173

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 165 TEALAQRDK 173
>NP_055459
          Length = 2346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 165 TEALAQRDK 173
>NP_001182189
          Length = 141

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 133 TEALAQRDK 141
>NP_001002812
          Length = 969

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 165 TEALAQRDK 173
>NP_001182190
          Length = 176

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 168 TEALAQRDK 176
>XP_006711719
          Length = 2302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 231 TEALAQRDK 239
>XP_006711717
          Length = 2385

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 231 TEALAQRDK 239
>XP_006711716
          Length = 2411

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 231 TEALAQRDK 239
>XP_006711715
          Length = 2428

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 165 TEALAQRDK 173
>XP_006711714
          Length = 2429

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 165 TEALAQRDK 173
>XP_006711713
          Length = 2432

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 168 TEALAQRDK 176
>XP_006711710
          Length = 2494

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 231 TEALAQRDK 239
>XP_006711709
          Length = 2495

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQRDK
Sbjct: 231 TEALAQRDK 239
>XP_006726402
          Length = 112

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQ+DK
Sbjct: 103 TETLAQKDK 111
>XP_006711153
          Length = 112

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE LAQ+DK
Sbjct: 103 TETLAQKDK 111
>XP_005246376
          Length = 612

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TENLAQRDK 9
          TEN+ QRD+
Sbjct: 10 TENMNQRDQ 18
>NP_001248339
          Length = 734

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TENLAQRD 8
          +ENL QRD
Sbjct: 73 SENLVQRD 80
>NP_003558
          Length = 825

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           +ENL QRD
Sbjct: 164 SENLVQRD 171
>NP_001248337
          Length = 825

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           +ENL QRD
Sbjct: 164 SENLVQRD 171
>NP_001248338
          Length = 825

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           +ENL QRD
Sbjct: 164 SENLVQRD 171
>NP_570899
          Length = 956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TENLAQRD 8
           TENL Q D
Sbjct: 141 TENLTQED 148
>NP_443161
          Length = 1412

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ENLAQRDK 9
           E+LAQ+DK
Sbjct: 219 EDLAQQDK 226
>XP_006718835
          Length = 677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TENLAQRD 8
           TENL Q D
Sbjct: 170 TENLTQED 177
>XP_005273858
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TENLAQRD 8
          TENL Q D
Sbjct: 55 TENLTQED 62
>XP_005273857
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TENLAQRD 8
          TENL Q D
Sbjct: 91 TENLTQED 98
>XP_006718834
          Length = 978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TENLAQRD 8
           TENL Q D
Sbjct: 163 TENLTQED 170
>XP_005273855
          Length = 985

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TENLAQRD 8
           TENL Q D
Sbjct: 170 TENLTQED 177
>XP_006710380
          Length = 1398

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ENLAQRDK 9
           E+LAQ+DK
Sbjct: 219 EDLAQQDK 226
>XP_005245788
          Length = 1434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ENLAQRDK 9
           E+LAQ+DK
Sbjct: 219 EDLAQQDK 226
>XP_006710379
          Length = 1452

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ENLAQRDK 9
           E+LAQ+DK
Sbjct: 219 EDLAQQDK 226
>XP_006710378
          Length = 1478

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ENLAQRDK 9
           E+LAQ+DK
Sbjct: 219 EDLAQQDK 226
>NP_149055
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ENLAQR 7
           ENLAQR
Sbjct: 581 ENLAQR 586
>XP_005246793
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ENLAQR 7
           ENLAQR
Sbjct: 506 ENLAQR 511
>XP_005246792
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ENLAQR 7
           ENLAQR
Sbjct: 523 ENLAQR 528
>XP_005246791
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ENLAQR 7
           ENLAQR
Sbjct: 537 ENLAQR 542
>XP_005246790
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ENLAQR 7
           ENLAQR
Sbjct: 546 ENLAQR 551
>XP_005246789
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ENLAQR 7
           ENLAQR
Sbjct: 557 ENLAQR 562
>XP_006710802
          Length = 276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TENLAQRDK 9
           TEN+  RD+
Sbjct: 250 TENIPTRDR 258
>NP_001207705
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NLAQRDK 9
          N+A+RDK
Sbjct: 45 NVAKRDK 51
>NP_001207703
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NLAQRDK 9
          N+A+RDK
Sbjct: 87 NVAKRDK 93
>NP_001207696
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NLAQRDK 9
           N+A+RDK
Sbjct: 183 NVAKRDK 189
>NP_001207699
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NLAQRDK 9
           N+A+RDK
Sbjct: 141 NVAKRDK 147
>NP_997237
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE+L+ +DK
Sbjct: 281 TEHLSDQDK 289
>NP_071926
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 361 TESEAQRD 368
>NP_062535
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TENLAQRDK 9
            TE+  QRD+
Sbjct: 1677 TEHAGQRDR 1685
>NP_877435
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+LAQ D
Sbjct: 747 TESLAQGD 754
>NP_001138998
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 289 ENLTQKD 295
>NP_001010982
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 284 ENLTQKD 290
>XP_006721763
          Length = 158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 139 ENLTQKD 145
>XP_006721762
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 215 ENLTQKD 221
>XP_006721761
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 215 ENLTQKD 221
>XP_006721760
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 215 ENLTQKD 221
>XP_006721759
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ENLAQRD 8
           ENL Q+D
Sbjct: 308 ENLTQKD 314
>XP_005267917
          Length = 2061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TENLAQRDK 9
            TE+  QRD+
Sbjct: 1677 TEHAGQRDR 1685
>XP_006718594
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENLAQRDK 9
           TE+L+ +DK
Sbjct: 194 TEHLSDQDK 202
>XP_005268557
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 361 TESEAQRD 368
>XP_006714856
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 163 TESEAQRD 170
>XP_005268556
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 283 TESEAQRD 290
>XP_006714855
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 361 TESEAQRD 368
>XP_006714854
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 303 TESEAQRD 310
>XP_005268555
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 361 TESEAQRD 368
>XP_005268554
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TENLAQRD 8
           TE+ AQRD
Sbjct: 361 TESEAQRD 368
>NP_006625
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TENLAQR 7
          T+NLAQ+
Sbjct: 55 TQNLAQK 61
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.116    0.288 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 474,070
Number of extensions: 690
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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