Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
NP_001123910                                                           17    2528
NP_003118                                                              17    2528
NP_001182461                                                           17    2528
XP_006717317                                                           17    2528
XP_006717316                                                           17    2528
XP_006717315                                                           17    2528
XP_006717314                                                           17    2528
XP_006717313                                                           17    2528
XP_006717312                                                           17    2528
XP_006717311                                                           17    2528
XP_006717310                                                           17    2528
XP_006717309                                                           17    2528
XP_006717308                                                           17    2528
NP_055731                                                              17    4312
NP_060833                                                              16    5631
NP_001026879                                                           16    5631
XP_005270007                                                           16    5631
XP_005270005                                                           16    5631
XP_005270003                                                           16    5631
NP_061927                                                              16    7355
XP_005269977                                                           16    7355
XP_006717968                                                           16    7355
XP_006717967                                                           16    7355
XP_006717966                                                           16    7355
XP_006717965                                                           16    7355
NP_001935                                                              16    7355
NP_000143                                                              15    9605
NP_001073271                                                           15    9605
NP_001073272                                                           15    9605
NP_055938                                                              15    9605
NP_904358                                                              15    9605
NP_001230728                                                           15    9605
NP_055796                                                              15    9605
NP_001070254                                                           15    9605
XP_005257251                                                           15    9605
XP_005257250                                                           15    9605
XP_005266640                                                           15    9605
XP_005266639                                                           15    9605
XP_006719950                                                           15    9605
XP_006718387                                                           15    9605
XP_006718386                                                           15    9605
XP_005264780                                                           15    9605
XP_006713127                                                           15    9605
XP_006713126                                                           15    9605
XP_005264779                                                           15    9605
XP_005264778                                                           15    9605
XP_005264777                                                           15    9605
NP_803173                                                              15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TENIESSEL 9
            TE+IESSEL
Sbjct: 1127 TESIESSEL 1135
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TENIESSEL 9
            TE+IESSEL
Sbjct: 1029 TESIESSEL 1037
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TENIESSEL 9
            TE+IESSEL
Sbjct: 1022 TESIESSEL 1030
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TENIESSEL 9
            TE+IESSEL
Sbjct: 1029 TESIESSEL 1037
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TENIESSEL 9
            TE+IESSEL
Sbjct: 1127 TESIESSEL 1135
>NP_001123910
          Length = 2477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2405 TENVKSSE 2412
>NP_003118
          Length = 2472

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2400 TENVKSSE 2407
>NP_001182461
          Length = 2452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2380 TENVKSSE 2387
>XP_006717317
          Length = 2498

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2426 TENVKSSE 2433
>XP_006717316
          Length = 2464

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2392 TENVKSSE 2399
>XP_006717315
          Length = 2469

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2397 TENVKSSE 2404
>XP_006717314
          Length = 2478

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2406 TENVKSSE 2413
>XP_006717313
          Length = 2483

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2411 TENVKSSE 2418
>XP_006717312
          Length = 2484

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2412 TENVKSSE 2419
>XP_006717311
          Length = 2489

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2417 TENVKSSE 2424
>XP_006717310
          Length = 2490

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2418 TENVKSSE 2425
>XP_006717309
          Length = 2505

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2433 TENVKSSE 2440
>XP_006717308
          Length = 2510

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TENIESSE 8
            TEN++SSE
Sbjct: 2438 TENVKSSE 2445
>NP_055731
          Length = 1503

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TENIESSE 8
            TEN+ES E
Sbjct: 1034 TENLESPE 1041
>NP_060833
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NIESSEL 9
           NIESSE+
Sbjct: 232 NIESSEI 238
>NP_001026879
          Length = 342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NIESSEL 9
           NIESSE+
Sbjct: 232 NIESSEI 238
>XP_005270007
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NIESSEL 9
           NIESSE+
Sbjct: 149 NIESSEI 155
>XP_005270005
          Length = 259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NIESSEL 9
           NIESSE+
Sbjct: 149 NIESSEI 155
>XP_005270003
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NIESSEL 9
           NIESSE+
Sbjct: 232 NIESSEI 238
>NP_061927
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           T+NIES ++
Sbjct: 99  TQNIESQKI 107
>XP_005269977
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           T+NIES ++
Sbjct: 99  TQNIESQKI 107
>XP_006717968
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           T+NIES ++
Sbjct: 99  TQNIESQKI 107
>XP_006717967
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           T+NIES ++
Sbjct: 99  TQNIESQKI 107
>XP_006717966
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           T+NIES ++
Sbjct: 99  TQNIESQKI 107
>XP_006717965
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           T+NIES ++
Sbjct: 105 TQNIESQKI 113
>NP_001935
          Length = 999

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ENIESSEL 9
           ENI SSEL
Sbjct: 278 ENILSSEL 285
>NP_000143
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENIESSEL 9
           EN+ SSE+
Sbjct: 139 ENLSSSEM 146
>NP_001073271
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENIESSEL 9
           EN+ SSE+
Sbjct: 139 ENLSSSEM 146
>NP_001073272
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENIESSEL 9
           EN+ SSE+
Sbjct: 139 ENLSSSEM 146
>NP_055938
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ENIESSE 8
            +N+ESSE
Sbjct: 1013 DNLESSE 1019
>NP_904358
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           TE++ SSE+
Sbjct: 146 TEDLSSSEI 154
>NP_001230728
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           TE++ SSE+
Sbjct: 146 TEDLSSSEI 154
>NP_055796
          Length = 1946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ENIESSE 8
            EN+ESS+
Sbjct: 1079 ENLESSQ 1085
>NP_001070254
          Length = 1735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    ENIESSE 8
            ENI SSE
Sbjct: 1307 ENISSSE 1313
>XP_005257251
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENIESSEL 9
           EN+ SSE+
Sbjct: 139 ENLSSSEM 146
>XP_005257250
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ENIESSEL 9
           EN+ SSE+
Sbjct: 139 ENLSSSEM 146
>XP_005266640
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           TE++ SSE+
Sbjct: 146 TEDLSSSEI 154
>XP_005266639
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           TE++ SSE+
Sbjct: 146 TEDLSSSEI 154
>XP_006719950
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TENIESSEL 9
           TE++ SSE+
Sbjct: 146 TEDLSSSEI 154
>XP_006718387
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    ENIESSE 8
            ENI SSE
Sbjct: 1370 ENISSSE 1376
>XP_006718386
          Length = 1822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    ENIESSE 8
            ENI SSE
Sbjct: 1370 ENISSSE 1376
>XP_005264780
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ENIESSE 8
           +N+ESSE
Sbjct: 665 DNLESSE 671
>XP_006713127
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ENIESSE 8
           +N+ESSE
Sbjct: 724 DNLESSE 730
>XP_006713126
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ENIESSE 8
           +N+ESSE
Sbjct: 959 DNLESSE 965
>XP_005264779
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ENIESSE 8
           +N+ESSE
Sbjct: 968 DNLESSE 974
>XP_005264778
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ENIESSE 8
           +N+ESSE
Sbjct: 980 DNLESSE 986
>XP_005264777
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ENIESSE 8
           +N+ESSE
Sbjct: 982 DNLESSE 988
>NP_803173
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NIESSEL 9
           N+ESSE+
Sbjct: 222 NVESSEV 228
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.278    0.104    0.225 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 347,097
Number of extensions: 442
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

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