Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              21     229
XP_006714104                                                           21     229
XP_005265800                                                           21     229
XP_006714103                                                           21     229
XP_006714102                                                           21     229
XP_005268838                                                           17    4312
XP_005268836                                                           17    4312
XP_005268834                                                           17    4312
XP_005268833                                                           17    4312
NP_037376                                                              17    4312
NP_000821                                                              16    5631
NP_783300                                                              16    5631
NP_001074003                                                           16    5631
XP_005261001                                                           16    5631
XP_005261000                                                           16    5631
XP_005260999                                                           16    5631
XP_006724054                                                           16    5631
XP_005254452                                                           16    5631
XP_005254451                                                           16    5631
NP_001073864                                                           16    7355
NP_001182760                                                           16    7355
NP_653248                                                              16    7355
NP_001036090                                                           16    7355
NP_004911                                                              16    7355
XP_005257912                                                           16    7355
XP_006722259                                                           16    7355
XP_006722258                                                           16    7355
XP_006722257                                                           16    7355
XP_006722256                                                           16    7355
XP_006714508                                                           16    7355
XP_006714507                                                           16    7355
XP_006710447                                                           16    7355
XP_006710446                                                           16    7355
XP_006710445                                                           16    7355
XP_005270577                                                           16    7355
NP_006243                                                              15    9605
NP_060761                                                              15    9605
NP_001265153                                                           15    9605
NP_065863                                                              15    9605
NP_001106882                                                           15    9605
NP_057107                                                              15    9605
NP_114102                                                              15    9605
NP_001231643                                                           15    9605
XP_005259182                                                           15    9605
XP_005259181                                                           15    9605
XP_005260057                                                           15    9605
XP_006722867                                                           15    9605
XP_006722866                                                           15    9605
XP_006722865                                                           15    9605
XP_005260058                                                           15    9605
XP_006722002                                                           15    9605
XP_006722000                                                           15    9605
XP_006721999                                                           15    9605
XP_006721998                                                           15    9605
XP_006721997                                                           15    9605
XP_006721996                                                           15    9605
XP_006721995                                                           15    9605
XP_005252332                                                           15    9605
XP_005252333                                                           15    9605
NP_057423                                                              15    9605
NP_612423                                                              15    9605
NP_115718                                                              15    9605
>NP_006197
          Length = 1089

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDYLVIMED 9
           TDYLVI+ED
Sbjct: 134 TDYLVIVED 142
>XP_006714104
          Length = 832

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDYLVIMED 9
           TDYLVI+ED
Sbjct: 159 TDYLVIVED 167
>XP_005265800
          Length = 1089

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDYLVIMED 9
           TDYLVI+ED
Sbjct: 134 TDYLVIVED 142
>XP_006714103
          Length = 1111

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDYLVIMED 9
           TDYLVI+ED
Sbjct: 156 TDYLVIVED 164
>XP_006714102
          Length = 1114

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDYLVIMED 9
           TDYLVI+ED
Sbjct: 159 TDYLVIVED 167
>XP_005268838
          Length = 478

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDYLVIMED 9
           +DY V++ED
Sbjct: 217 SDYYVMLED 225
>XP_005268836
          Length = 478

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDYLVIMED 9
           +DY V++ED
Sbjct: 217 SDYYVMLED 225
>XP_005268834
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDYLVIMED 9
           +DY V++ED
Sbjct: 246 SDYYVMLED 254
>XP_005268833
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDYLVIMED 9
           +DY V++ED
Sbjct: 246 SDYYVMLED 254
>NP_037376
          Length = 478

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDYLVIMED 9
           +DY V++ED
Sbjct: 217 SDYYVMLED 225
>NP_000821
          Length = 918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY ++ME
Sbjct: 746 TDYALLME 753
>NP_783300
          Length = 905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY ++ME
Sbjct: 731 TDYALLME 738
>NP_001074003
          Length = 2214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY+ +ME
Sbjct: 876 TDYVEVME 883
>XP_005261001
          Length = 903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY ++ME
Sbjct: 731 TDYALLME 738
>XP_005261000
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY ++ME
Sbjct: 746 TDYALLME 753
>XP_005260999
          Length = 934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY ++ME
Sbjct: 731 TDYALLME 738
>XP_006724054
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY ++ME
Sbjct: 746 TDYALLME 753
>XP_005254452
          Length = 2188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY+ +ME
Sbjct: 876 TDYVEVME 883
>XP_005254451
          Length = 2214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           TDY+ +ME
Sbjct: 876 TDYVEVME 883
>NP_001073864
          Length = 1374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           T YL++ME
Sbjct: 196 TPYLLVME 203
>NP_001182760
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TDYLVIMED 9
            TDY+ IM++
Sbjct: 1161 TDYVRIMQE 1169
>NP_653248
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DYLVIME 8
          DY V+ME
Sbjct: 70 DYAVVME 76
>NP_001036090
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DYLVIME 8
          DY V+ME
Sbjct: 70 DYAVVME 76
>NP_004911
          Length = 1271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           T YL++ME
Sbjct: 93  TPYLLVME 100
>XP_005257912
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           T YL++ME
Sbjct: 196 TPYLLVME 203
>XP_006722259
          Length = 1326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           T YL++ME
Sbjct: 148 TPYLLVME 155
>XP_006722258
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TDYLVIME 8
          T YL++ME
Sbjct: 29 TPYLLVME 36
>XP_006722257
          Length = 1324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           T YL++ME
Sbjct: 196 TPYLLVME 203
>XP_006722256
          Length = 1326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDYLVIME 8
           T YL++ME
Sbjct: 148 TPYLLVME 155
>XP_006714508
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DYLVIME 8
          DY V+ME
Sbjct: 87 DYAVVME 93
>XP_006714507
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DYLVIME 8
          DY V+ME
Sbjct: 87 DYAVVME 93
>XP_006710447
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TDYLVIMED 9
            TDY+ IM++
Sbjct: 1070 TDYVRIMQE 1078
>XP_006710446
          Length = 1239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TDYLVIMED 9
            TDY+ IM++
Sbjct: 1117 TDYVRIMQE 1125
>XP_006710445
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TDYLVIMED 9
            TDY+ IM++
Sbjct: 1128 TDYVRIMQE 1136
>XP_005270577
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TDYLVIMED 9
            TDY+ IM++
Sbjct: 1128 TDYVRIMQE 1136
>NP_006243
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  TDYLVIME 8
          TD+ ++ME
Sbjct: 87 TDFFMVME 94
>NP_060761
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYLVIMED 9
           +YL IM D
Sbjct: 543 EYLAIMND 550
>NP_001265153
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYLVIMED 9
           +YL IM D
Sbjct: 244 EYLAIMND 251
>NP_065863
          Length = 2047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    DYLVIMED 9
            +YL ++ED
Sbjct: 1629 EYLALLED 1636
>NP_001106882
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYLVIMED 9
           +YL IM D
Sbjct: 567 EYLAIMND 574
>NP_057107
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  YLVIME 8
          YLV+ME
Sbjct: 27 YLVVME 32
>NP_114102
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TDYLVIMED 9
          TDY + ME+
Sbjct: 30 TDYWLYMEE 38
>NP_001231643
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYLVIMED 9
           +YL IM D
Sbjct: 455 EYLAIMND 462
>XP_005259182
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TDYLVIMED 9
          TDY + ME+
Sbjct: 30 TDYWLYMEE 38
>XP_005259181
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TDYLVIMED 9
          TDY + ME+
Sbjct: 30 TDYWLYMEE 38
>XP_005260057
          Length = 2113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    DYLVIMED 9
            +YL ++ED
Sbjct: 1695 EYLALLED 1702
>XP_006722867
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DYLVIMED 9
           +YL ++ED
Sbjct: 741 EYLALLED 748
>XP_006722866
          Length = 1778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    DYLVIMED 9
            +YL ++ED
Sbjct: 1360 EYLALLED 1367
>XP_006722865
          Length = 2078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    DYLVIMED 9
            +YL ++ED
Sbjct: 1660 EYLALLED 1667
>XP_005260058
          Length = 2082

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    DYLVIMED 9
            +YL ++ED
Sbjct: 1664 EYLALLED 1671
>XP_006722002
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YLVIMED 9
           YL+IM+D
Sbjct: 248 YLLIMKD 254
>XP_006722000
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YLVIMED 9
          YL+IM+D
Sbjct: 42 YLLIMKD 48
>XP_006721999
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YLVIMED 9
          YL+IM+D
Sbjct: 79 YLLIMKD 85
>XP_006721998
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YLVIMED 9
          YL+IM+D
Sbjct: 79 YLLIMKD 85
>XP_006721997
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YLVIMED 9
          YL+IM+D
Sbjct: 79 YLLIMKD 85
>XP_006721996
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YLVIMED 9
           YL+IM+D
Sbjct: 97  YLLIMKD 103
>XP_006721995
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YLVIMED 9
           YL+IM+D
Sbjct: 248 YLLIMKD 254
>XP_005252332
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   DYLVIMED 9
           DY++++ED
Sbjct: 205 DYVLMVED 212
>XP_005252333
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   DYLVIMED 9
           DY++++ED
Sbjct: 205 DYVLMVED 212
>NP_057423
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YLVIMED 9
          YL+IM+D
Sbjct: 42 YLLIMKD 48
>NP_612423
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYLVIMED 9
           DY V+ ED
Sbjct: 259 DYSVLFED 266
>NP_115718
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   DYLVIMED 9
           DY++++ED
Sbjct: 205 DYVLMVED 212
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.144    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 462,756
Number of extensions: 922
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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