Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     869
XP_005266703                                                           19     869
NP_001171835                                                           17    2528
NP_116264                                                              17    2528
XP_005257804                                                           17    2528
XP_005257803                                                           17    2528
XP_005276377                                                           17    3301
NP_001229326                                                           17    4312
NP_002813                                                              17    4312
NP_003418                                                              17    4312
XP_005249427                                                           17    4312
XP_005249426                                                           17    4312
XP_005249421                                                           17    4312
NP_001243779                                                           16    5631
NP_596869                                                              16    5631
XP_006712787                                                           16    5631
XP_006712786                                                           16    5631
NP_064446                                                              16    5631
NP_001254479                                                           16    5631
NP_612468                                                              16    7355
NP_056520                                                              15    9605
NP_064425                                                              15    9605
NP_001001290                                                           15    9605
NP_004298                                                              15    9605
NP_775098                                                              15    9605
NP_001159522                                                           15    9605
NP_037528                                                              15    9605
NP_001269970                                                           15    9605
NP_001269971                                                           15    9605
NP_079514                                                              15    9605
NP_001011885                                                           15    9605
XP_005261636                                                           15    9605
XP_005261634                                                           15    9605
XP_005261632                                                           15    9605
XP_005261631                                                           15    9605
XP_005261630                                                           15    9605
XP_005261629                                                           15    9605
XP_005261006                                                           15    9605
XP_006724055                                                           15    9605
XP_006720636                                                           15    9605
XP_005248158                                                           15    9605
XP_006714075                                                           15    9605
XP_006714074                                                           15    9605
XP_006714073                                                           15    9605
XP_006714072                                                           15    9605
XP_006714071                                                           15    9605
XP_006714070                                                           15    9605
XP_006714069                                                           15    9605
XP_006714068                                                           15    9605
XP_006714032                                                           15    9605
XP_006714031                                                           15    9605
>NP_443179
          Length = 2170

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TDVGIETLA 9
            TDVGI TLA
Sbjct: 2089 TDVGIATLA 2097
>XP_005266703
          Length = 1501

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TDVGIETLA 9
            TDVGI TLA
Sbjct: 1420 TDVGIATLA 1428
>NP_001171835
          Length = 404

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TDVGIETLA 9
           TDVG  TLA
Sbjct: 255 TDVGFTTLA 263
>NP_116264
          Length = 436

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TDVGIETLA 9
           TDVG  TLA
Sbjct: 287 TDVGFTTLA 295
>XP_005257804
          Length = 406

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TDVGIETLA 9
           TDVG  TLA
Sbjct: 257 TDVGFTTLA 265
>XP_005257803
          Length = 438

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TDVGIETLA 9
           TDVG  TLA
Sbjct: 289 TDVGFTTLA 297
>XP_005276377
          Length = 328

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TDVGIET 7
          TD+G+ET
Sbjct: 23 TDIGLET 29
>NP_001229326
          Length = 357

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TDVGIET 7
           TDVG++T
Sbjct: 171 TDVGVDT 177
>NP_002813
          Length = 350

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TDVGIET 7
           TDVG++T
Sbjct: 164 TDVGVDT 170
>NP_003418
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVGIETLA 9
           T+VG+E LA
Sbjct: 115 TEVGLEDLA 123
>XP_005249427
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVGIETLA 9
           T+VG+E LA
Sbjct: 115 TEVGLEDLA 123
>XP_005249426
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVGIETLA 9
           T+VG+E LA
Sbjct: 115 TEVGLEDLA 123
>XP_005249421
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVGIETLA 9
           T+VG+E LA
Sbjct: 115 TEVGLEDLA 123
>NP_001243779
          Length = 34350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TDVGIE 6
            TDVGIE
Sbjct: 5287 TDVGIE 5292
>NP_596869
          Length = 33423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TDVGIE 6
            TDVGIE
Sbjct: 4360 TDVGIE 4365
>XP_006712787
          Length = 33978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TDVGIE 6
            TDVGIE
Sbjct: 5288 TDVGIE 5293
>XP_006712786
          Length = 35484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TDVGIE 6
            TDVGIE
Sbjct: 5288 TDVGIE 5293
>NP_064446
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DVGIETL 8
           DVG++TL
Sbjct: 247 DVGVDTL 253
>NP_001254479
          Length = 35991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TDVGIE 6
            TDVGIE
Sbjct: 5604 TDVGIE 5609
>NP_612468
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDVGIETLA 9
           TD+ ++TLA
Sbjct: 219 TDLDVDTLA 227
>NP_056520
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 362 TDVAVET 368
>NP_064425
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GIETLA 9
           GIETLA
Sbjct: 362 GIETLA 367
>NP_001001290
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GIETLA 9
           GIETLA
Sbjct: 333 GIETLA 338
>NP_004298
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>NP_775098
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>NP_001159522
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>NP_037528
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VGIETL 8
           VGIETL
Sbjct: 676 VGIETL 681
>NP_001269970
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VGIETL 8
           VGIETL
Sbjct: 676 VGIETL 681
>NP_001269971
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VGIETL 8
           VGIETL
Sbjct: 676 VGIETL 681
>NP_079514
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDVGIETL 8
           TD+ I+TL
Sbjct: 217 TDIDIDTL 224
>NP_001011885
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDVGIETL 8
           TD+ I+TL
Sbjct: 217 TDIDIDTL 224
>XP_005261636
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 295 TDVAVET 301
>XP_005261634
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 362 TDVAVET 368
>XP_005261632
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 295 TDVAVET 301
>XP_005261631
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 362 TDVAVET 368
>XP_005261630
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 362 TDVAVET 368
>XP_005261629
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TDVGIET 7
           TDV +ET
Sbjct: 362 TDVAVET 368
>XP_005261006
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VGIETL 8
           VGIETL
Sbjct: 272 VGIETL 277
>XP_006724055
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VGIETL 8
           VGIETL
Sbjct: 377 VGIETL 382
>XP_006720636
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TDVGIETL 8
           TD+ I+TL
Sbjct: 217 TDIDIDTL 224
>XP_005248158
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714075
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714074
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714073
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714072
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714071
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714070
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714069
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714068
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVGIETLA 9
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714032
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GIETLA 9
           GIETLA
Sbjct: 333 GIETLA 338
>XP_006714031
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GIETLA 9
           GIETLA
Sbjct: 362 GIETLA 367
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.132    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,061
Number of extensions: 501
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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