Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              21     229
XP_005250103                                                           21     229
XP_005250102                                                           21     229
NP_001172048                                                           18    1482
NP_001172047                                                           18    1482
NP_061127                                                              18    1482
XP_005247681                                                           18    1482
XP_005247679                                                           18    1482
XP_005247678                                                           18    1482
NP_002289                                                              18    1935
XP_005266431                                                           18    1935
NP_000436                                                              17    4312
NP_958780                                                              17    4312
NP_958781                                                              17    4312
NP_958785                                                              17    4312
NP_958783                                                              17    4312
NP_958786                                                              17    4312
NP_079052                                                              17    4312
NP_958782                                                              17    4312
NP_958784                                                              17    4312
XP_005254732                                                           17    4312
XP_005254731                                                           17    4312
XP_006720754                                                           17    4312
XP_005254729                                                           17    4312
XP_005254730                                                           17    4312
XP_005254728                                                           17    4312
XP_005254727                                                           17    4312
XP_006716654                                                           17    4312
XP_005251041                                                           17    4312
XP_005251040                                                           17    4312
XP_006716653                                                           17    4312
XP_006716652                                                           17    4312
XP_005251039                                                           17    4312
XP_005251038                                                           17    4312
XP_005251036                                                           17    4312
XP_005251037                                                           17    4312
XP_005251035                                                           17    4312
XP_006716651                                                           17    4312
XP_005251034                                                           17    4312
XP_005251033                                                           17    4312
NP_078966                                                              16    5631
NP_001121167                                                           16    5631
NP_001161066                                                           16    5631
NP_071353                                                              16    5631
NP_065875                                                              16    5631
NP_000299                                                              16    5631
XP_005257627                                                           16    5631
XP_005252604                                                           16    5631
XP_005252603                                                           16    5631
XP_005252601                                                           16    5631
XP_006717551                                                           16    5631
XP_005252600                                                           16    5631
XP_005252599                                                           16    5631
XP_006717550                                                           16    5631
NP_071351                                                              16    7355
NP_056210                                                              16    7355
NP_620144                                                              16    7355
NP_001076088                                                           16    7355
XP_005271460                                                           16    7355
XP_005250310                                                           16    7355
NP_001278296                                                           15    9605
NP_001278295                                                           15    9605
NP_057608                                                              15    9605
XP_006721116                                                           15    9605
XP_005255419                                                           15    9605
XP_005255418                                                           15    9605
XP_005246846                                                           15    9605
NP_004578                                                              15    9605
NP_001036041                                                           15    9605
NP_963868                                                              15    9605
NP_113642                                                              15    9605
>NP_004324
          Length = 766

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDVAQSNPK 9
           TDVA+SNPK
Sbjct: 142 TDVARSNPK 150
>XP_005250103
          Length = 758

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDVAQSNPK 9
           TDVA+SNPK
Sbjct: 142 TDVARSNPK 150
>XP_005250102
          Length = 767

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TDVAQSNPK 9
           TDVA+SNPK
Sbjct: 142 TDVARSNPK 150
>NP_001172048
          Length = 581

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVAQSNPK 9
           TD+ Q+NPK
Sbjct: 160 TDLIQANPK 168
>NP_001172047
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVAQSNPK 9
           TD+ Q+NPK
Sbjct: 160 TDLIQANPK 168
>NP_061127
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVAQSNPK 9
           TD+ Q+NPK
Sbjct: 160 TDLIQANPK 168
>XP_005247681
          Length = 496

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TDVAQSNPK 9
          TD+ Q+NPK
Sbjct: 46 TDLIQANPK 54
>XP_005247679
          Length = 528

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TDVAQSNPK 9
          TD+ Q+NPK
Sbjct: 78 TDLIQANPK 86
>XP_005247678
          Length = 582

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TDVAQSNPK 9
           TD+ Q+NPK
Sbjct: 160 TDLIQANPK 168
>NP_002289
          Length = 627

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TDVAQSNPK 9
           TDV + NPK
Sbjct: 353 TDVVRGNPK 361
>XP_005266431
          Length = 627

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TDVAQSNPK 9
           TDV + NPK
Sbjct: 353 TDVVRGNPK 361
>NP_000436
          Length = 4574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 151 DIADGNPK 158
>NP_958780
          Length = 4533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 110 DIADGNPK 117
>NP_958781
          Length = 4525

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 102 DIADGNPK 109
>NP_958785
          Length = 4551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 128 DIADGNPK 135
>NP_958783
          Length = 4515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  DVAQSNPK 9
          D+A  NPK
Sbjct: 92 DIADGNPK 99
>NP_958786
          Length = 4547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 124 DIADGNPK 131
>NP_079052
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>NP_958782
          Length = 4684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 261 DIADGNPK 268
>NP_958784
          Length = 4547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 124 DIADGNPK 131
>XP_005254732
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_005254731
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_006720754
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_005254729
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_005254730
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_005254728
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_005254727
          Length = 1746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DVA+S PK
Sbjct: 804 DVAKSTPK 811
>XP_006716654
          Length = 3562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 266 DIADGNPK 273
>XP_005251041
          Length = 4520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 97  DIADGNPK 104
>XP_005251040
          Length = 4524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 101 DIADGNPK 108
>XP_006716653
          Length = 4529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 106 DIADGNPK 113
>XP_006716652
          Length = 4529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 106 DIADGNPK 113
>XP_005251039
          Length = 4530

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 107 DIADGNPK 114
>XP_005251038
          Length = 4538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 115 DIADGNPK 122
>XP_005251036
          Length = 4552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 129 DIADGNPK 136
>XP_005251037
          Length = 4552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 129 DIADGNPK 136
>XP_005251035
          Length = 4556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 133 DIADGNPK 140
>XP_006716651
          Length = 4579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 156 DIADGNPK 163
>XP_005251034
          Length = 4685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 266 DIADGNPK 273
>XP_005251033
          Length = 4689

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DVAQSNPK 9
           D+A  NPK
Sbjct: 266 DIADGNPK 273
>NP_078966
          Length = 14507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    DVAQSNP 8
            DV+Q+NP
Sbjct: 4730 DVSQTNP 4736
>NP_001121167
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           T+VAQSN
Sbjct: 147 TEVAQSN 153
>NP_001161066
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           T+VAQSN
Sbjct: 148 TEVAQSN 154
>NP_071353
          Length = 1181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TDVAQSNPK 9
           +D+AQS+P+
Sbjct: 172 SDLAQSDPE 180
>NP_065875
          Length = 1958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>NP_000299
          Length = 498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           T+VAQSN
Sbjct: 165 TEVAQSN 171
>XP_005257627
          Length = 1013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TDVAQSNPK 9
          +D+AQS+P+
Sbjct: 4  SDLAQSDPE 12
>XP_005252604
          Length = 1386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>XP_005252603
          Length = 1457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>XP_005252601
          Length = 1948

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 245 TDVAKSN 251
>XP_006717551
          Length = 1958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>XP_005252600
          Length = 1958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>XP_005252599
          Length = 1958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>XP_006717550
          Length = 1958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDVAQSN 7
           TDVA+SN
Sbjct: 255 TDVAKSN 261
>NP_071351
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           + AQSNP+
Sbjct: 151 EAAQSNPE 158
>NP_056210
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DV+ SNP+
Sbjct: 225 DVSHSNPE 232
>NP_620144
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  DVAQSNPK 9
          D+AQS+P+
Sbjct: 21 DLAQSDPE 28
>NP_001076088
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  DVAQSNPK 9
          D+AQS+P+
Sbjct: 21 DLAQSDPE 28
>XP_005271460
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  DVAQSNPK 9
          D+AQS+P+
Sbjct: 21 DLAQSDPE 28
>XP_005250310
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DVAQSNPK 9
           DV+ SNP+
Sbjct: 225 DVSHSNPE 232
>NP_001278296
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TDVAQSNP 8
           TDVA S P
Sbjct: 303 TDVAVSTP 310
>NP_001278295
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TDVAQSNP 8
           TDVA S P
Sbjct: 397 TDVAVSTP 404
>NP_057608
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DVAQSNP 8
           D+A SNP
Sbjct: 223 DMAHSNP 229
>XP_006721116
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DVAQSNP 8
           D+A SNP
Sbjct: 162 DMAHSNP 168
>XP_005255419
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DVAQSNP 8
           D+A SNP
Sbjct: 162 DMAHSNP 168
>XP_005255418
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DVAQSNP 8
           D+A SNP
Sbjct: 223 DMAHSNP 229
>XP_005246846
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDVAQSNPK 9
           TD+A S+P+
Sbjct: 216 TDLALSSPR 224
>NP_004578
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TDVAQS 6
           TDVAQS
Sbjct: 180 TDVAQS 185
>NP_001036041
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TDVAQS 6
           TDVAQS
Sbjct: 180 TDVAQS 185
>NP_963868
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TDVAQSNPK 9
           TD+A S+P+
Sbjct: 216 TDLALSSPR 224
>NP_113642
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VAQSNPK 9
           +AQSNP+
Sbjct: 509 LAQSNPQ 515
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.109    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 588,025
Number of extensions: 808
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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