Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              19     869
XP_006725230                                                           17    3301
XP_006720283                                                           17    3301
NP_065869                                                              17    3301
NP_004064                                                              17    4312
NP_940992                                                              16    5631
NP_647593                                                              16    5631
NP_647601                                                              16    5631
NP_004296                                                              16    5631
NP_940993                                                              16    5631
NP_647598                                                              16    5631
NP_647600                                                              16    5631
NP_940991                                                              16    5631
NP_647596                                                              16    5631
NP_001719                                                              16    5631
NP_647595                                                              16    5631
NP_647594                                                              16    5631
NP_647599                                                              16    5631
NP_775859                                                              16    5631
NP_647597                                                              16    5631
XP_005259676                                                           16    5631
XP_005263705                                                           16    5631
XP_005263704                                                           16    5631
XP_006712497                                                           16    5631
XP_006712496                                                           16    5631
XP_005263703                                                           16    5631
XP_006712495                                                           16    5631
XP_006712494                                                           16    5631
XP_006712493                                                           16    5631
XP_006712492                                                           16    5631
XP_006712491                                                           16    5631
XP_006712490                                                           16    5631
XP_005263702                                                           16    5631
XP_005263701                                                           16    5631
XP_006712489                                                           16    5631
XP_006712488                                                           16    5631
XP_005263700                                                           16    5631
XP_006712487                                                           16    5631
XP_005263699                                                           16    5631
NP_000531                                                              16    7355
NP_001036188                                                           16    7355
NP_932349                                                              16    7355
NP_001180564                                                           16    7355
NP_001269920                                                           16    7355
NP_001269919                                                           16    7355
NP_001269917                                                           16    7355
NP_001269916                                                           16    7355
NP_001269918                                                           16    7355
NP_066284                                                              16    7355
XP_006723382                                                           16    7355
XP_006723381                                                           16    7355
XP_006723380                                                           16    7355
XP_006720309                                                           16    7355
XP_006720069                                                           16    7355
XP_006720068                                                           16    7355
XP_005273584                                                           16    7355
NP_057324                                                              16    7355
NP_878185                                                              16    7355
NP_001030598                                                           15    9605
NP_001512                                                              15    9605
XP_006718983                                                           15    9605
XP_006718982                                                           15    9605
XP_006718981                                                           15    9605
XP_006718980                                                           15    9605
XP_006718979                                                           15    9605
XP_005264330                                                           15    9605
XP_005264329                                                           15    9605
NP_079280                                                              15    9605
>NP_004251
          Length = 1208

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TDQALLTL 8
           TDQALLTL
Sbjct: 684 TDQALLTL 691
>XP_006725230
          Length = 2636

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TDQALLTLQ 9
            TD AL+TL+
Sbjct: 1711 TDSALITLE 1719
>XP_006720283
          Length = 2636

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TDQALLTLQ 9
            TD AL+TL+
Sbjct: 1711 TDSALITLE 1719
>NP_065869
          Length = 2458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TDQALLTLQ 9
            TD AL+TL+
Sbjct: 1533 TDSALITLE 1541
>NP_004064
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TDQALLTL 8
           TDQALL L
Sbjct: 569 TDQALLML 576
>NP_940992
          Length = 176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TDQALLTLQ 9
           +DQA++TL+
Sbjct: 100 SDQAIITLR 108
>NP_647593
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_647601
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_004296
          Length = 454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_940993
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TDQALLTLQ 9
           +DQA++TL+
Sbjct: 129 SDQAIITLR 137
>NP_647598
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_647600
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_940991
          Length = 269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TDQALLTLQ 9
           +DQA++TL+
Sbjct: 193 SDQAIITLR 201
>NP_647596
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_001719
          Length = 385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TDQALLTLQ 9
           +DQA++TL+
Sbjct: 309 SDQAIITLR 317
>NP_647595
          Length = 506

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_647594
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_647599
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_775859
          Length = 1326

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 661 DQALLTI 667
>NP_647597
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_005259676
          Length = 269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TDQALLTLQ 9
           +DQA++TL+
Sbjct: 193 SDQAIITLR 201
>XP_005263705
          Length = 385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 96  DQALLTM 102
>XP_005263704
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712497
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712496
          Length = 455

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_005263703
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712495
          Length = 485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712494
          Length = 498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712493
          Length = 513

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712492
          Length = 521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712491
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712490
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 96  DQALLTM 102
>XP_005263702
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 96  DQALLTM 102
>XP_005263701
          Length = 562

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712489
          Length = 564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712488
          Length = 564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_005263700
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>XP_006712487
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 96  DQALLTM 102
>XP_005263699
          Length = 608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DQALLTL 8
           DQALLT+
Sbjct: 120 DQALLTM 126
>NP_000531
          Length = 5038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TDQALLTL 8
            TDQ L+TL
Sbjct: 3528 TDQDLITL 3535
>NP_001036188
          Length = 5033

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TDQALLTL 8
            TDQ L+TL
Sbjct: 3523 TDQDLITL 3530
>NP_932349
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>NP_001180564
          Length = 170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 42 DQAVATLQ 49
>NP_001269920
          Length = 158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>NP_001269919
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>NP_001269917
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>NP_001269916
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>NP_001269918
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>NP_066284
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>XP_006723382
          Length = 5027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TDQALLTL 8
            TDQ L+TL
Sbjct: 3523 TDQDLITL 3530
>XP_006723381
          Length = 5031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TDQALLTL 8
            TDQ L+TL
Sbjct: 3527 TDQDLITL 3534
>XP_006723380
          Length = 5032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TDQALLTL 8
            TDQ L+TL
Sbjct: 3528 TDQDLITL 3535
>XP_006720309
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>XP_006720069
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>XP_006720068
          Length = 233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DQALLTLQ 9
          DQA+ TLQ
Sbjct: 70 DQAVATLQ 77
>XP_005273584
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TDQALLTLQ 9
           TD+  LTLQ
Sbjct: 241 TDEETLTLQ 249
>NP_057324
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TDQALLTLQ 9
           TD+  LTLQ
Sbjct: 241 TDEETLTLQ 249
>NP_878185
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TDQALLTLQ 9
           TD+  LTLQ
Sbjct: 241 TDEETLTLQ 249
>NP_001030598
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DQALLTLQ 9
           DQA+ TLQ
Sbjct: 613 DQAVRTLQ 620
>NP_001512
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DQALLTLQ 9
           DQA+ TLQ
Sbjct: 613 DQAVRTLQ 620
>XP_006718983
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDQALLT 7
           T+QALLT
Sbjct: 415 TNQALLT 421
>XP_006718982
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDQALLT 7
           T+QALLT
Sbjct: 415 TNQALLT 421
>XP_006718981
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDQALLT 7
           T+QALLT
Sbjct: 415 TNQALLT 421
>XP_006718980
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDQALLT 7
           T+QALLT
Sbjct: 415 TNQALLT 421
>XP_006718979
          Length = 844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDQALLT 7
           T+QALLT
Sbjct: 415 TNQALLT 421
>XP_005264330
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DQALLTLQ 9
           DQA+ TLQ
Sbjct: 624 DQAVRTLQ 631
>XP_005264329
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DQALLTLQ 9
           DQA+ TLQ
Sbjct: 652 DQAVRTLQ 659
>NP_079280
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TDQALLT 7
           T+QALLT
Sbjct: 415 TNQALLT 421
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.126    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 354,763
Number of extensions: 433
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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