Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     299
NP_078858                                                              17    2528
NP_001278232                                                           17    2528
NP_001278214                                                           17    2528
NP_065976                                                              17    3301
XP_006710856                                                           17    3301
NP_006217                                                              16    5631
XP_005246701                                                           16    5631
XP_005246700                                                           16    5631
NP_001167535                                                           16    7355
NP_001167534                                                           16    7355
NP_001167536                                                           16    7355
NP_056934                                                              16    7355
NP_075598                                                              16    7355
NP_001167538                                                           16    7355
NP_001035915                                                           16    7355
NP_689564                                                              16    7355
NP_001257578                                                           16    7355
NP_001257577                                                           16    7355
NP_780778                                                              16    7355
NP_005896                                                              16    7355
NP_001120689                                                           16    7355
NP_001135392                                                           16    7355
NP_001135391                                                           16    7355
XP_005274644                                                           16    7355
XP_005258838                                                           16    7355
XP_006721514                                                           16    7355
XP_006721513                                                           16    7355
XP_005256514                                                           16    7355
XP_005266461                                                           16    7355
XP_005266460                                                           16    7355
XP_005266458                                                           16    7355
XP_006719890                                                           16    7355
XP_006716372                                                           16    7355
XP_006716371                                                           16    7355
XP_006716370                                                           16    7355
XP_006716369                                                           16    7355
XP_006716368                                                           16    7355
XP_006716367                                                           16    7355
XP_006716366                                                           16    7355
NP_997244                                                              15    9605
NP_061325                                                              15    9605
NP_940998                                                              15    9605
NP_001155313                                                           15    9605
NP_001271169                                                           15    9605
NP_001271170                                                           15    9605
NP_061872                                                              15    9605
NP_001153182                                                           15    9605
NP_001153179                                                           15    9605
NP_000188                                                              15    9605
NP_775922                                                              15    9605
XP_005276759                                                           15    9605
XP_005276750                                                           15    9605
XP_003846353                                                           15    9605
XP_005261913                                                           15    9605
XP_005261910                                                           15    9605
XP_005261905                                                           15    9605
XP_003846349                                                           15    9605
XP_006723893                                                           15    9605
XP_005260515                                                           15    9605
XP_006723892                                                           15    9605
XP_006723891                                                           15    9605
XP_006723890                                                           15    9605
XP_005269963                                                           15    9605
XP_005269962                                                           15    9605
XP_005252027                                                           15    9605
XP_006717157                                                           15    9605
XP_005264092                                                           15    9605
XP_003960959                                                           15    9605
NP_001035552                                                           15    9605
NP_001153181                                                           15    9605
NP_004852                                                              15    9605
>NP_004351
          Length = 882

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TAYFSLNTR 9
          TAYFSL+TR
Sbjct: 66 TAYFSLDTR 74
>NP_078858
          Length = 4981

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TAYFSLNT 8
            T+YFSL+T
Sbjct: 3555 TSYFSLST 3562
>NP_001278232
          Length = 4983

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TAYFSLNT 8
            T+YFSL+T
Sbjct: 3557 TSYFSLST 3564
>NP_001278214
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    TAYFSLNT 8
            T+YFSL+T
Sbjct: 3557 TSYFSLST 3564
>NP_065976
          Length = 1223

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TAYFSLNTR 9
           TAY S NTR
Sbjct: 631 TAYLSDNTR 639
>XP_006710856
          Length = 978

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TAYFSLNTR 9
           TAY S NTR
Sbjct: 386 TAYLSDNTR 394
>NP_006217
          Length = 1095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS NT+
Sbjct: 705 SYFSANTK 712
>XP_005246701
          Length = 1016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS NT+
Sbjct: 626 SYFSANTK 633
>XP_005246700
          Length = 1021

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS NT+
Sbjct: 631 SYFSANTK 638
>NP_001167535
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 103 TTYFSVN 109
>NP_001167534
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>NP_001167536
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>NP_056934
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>NP_075598
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>NP_001167538
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 144 TTYFSVN 150
>NP_001035915
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>NP_689564
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>NP_001257578
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>NP_001257577
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>NP_780778
          Length = 180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           +YF LN R
Sbjct: 161 SYFKLNNR 168
>NP_005896
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY+ LN R
Sbjct: 240 AYYELNNR 247
>NP_001120689
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY+ LN R
Sbjct: 277 AYYELNNR 284
>NP_001135392
          Length = 181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           +YF LN R
Sbjct: 162 SYFKLNNR 169
>NP_001135391
          Length = 195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           +YF LN R
Sbjct: 176 SYFKLNNR 183
>XP_005274644
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           +YF LN R
Sbjct: 177 SYFKLNNR 184
>XP_005258838
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TAYFSLNT 8
           T YFS++T
Sbjct: 548 TEYFSMHT 555
>XP_006721514
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>XP_006721513
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>XP_005256514
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TAYFSLN 7
          T YF+LN
Sbjct: 25 TVYFALN 31
>XP_005266461
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY+ LN R
Sbjct: 154 AYYELNNR 161
>XP_005266460
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY+ LN R
Sbjct: 191 AYYELNNR 198
>XP_005266458
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY+ LN R
Sbjct: 240 AYYELNNR 247
>XP_006719890
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY+ LN R
Sbjct: 277 AYYELNNR 284
>XP_006716372
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 103 TTYFSVN 109
>XP_006716371
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>XP_006716370
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>XP_006716369
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>XP_006716368
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>XP_006716367
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>XP_006716366
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TAYFSLN 7
           T YFS+N
Sbjct: 111 TTYFSVN 117
>NP_997244
          Length = 3169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AYFSLNTR 9
            A FSLNT+
Sbjct: 2855 AEFSLNTQ 2862
>NP_061325
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 781 YFDLNT 786
>NP_940998
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 781 YFDLNT 786
>NP_001155313
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 781 YFDLNT 786
>NP_001271169
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TAYFSLNT 8
           T+Y S+NT
Sbjct: 161 TSYSSINT 168
>NP_001271170
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TAYFSLNT 8
           T+Y S+NT
Sbjct: 161 TSYSSINT 168
>NP_061872
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TAYFSLNT 8
           T+Y S+NT
Sbjct: 161 TSYSSINT 168
>NP_001153182
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YFSLNTR 9
           YF+LN R
Sbjct: 204 YFTLNPR 210
>NP_001153179
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YFSLNTR 9
           YF+LN R
Sbjct: 272 YFTLNPR 278
>NP_000188
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY  LNT+
Sbjct: 301 AYLKLNTK 308
>NP_775922
          Length = 6996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    AYFSLNT 8
            A+FS NT
Sbjct: 4450 AFFSFNT 4456
>XP_005276759
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS+N +
Sbjct: 129 SYFSINAK 136
>XP_005276750
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS+N +
Sbjct: 129 SYFSINAK 136
>XP_003846353
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS+N +
Sbjct: 129 SYFSINAK 136
>XP_005261913
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   YFSLNTR 9
           YF LN R
Sbjct: 275 YFKLNAR 281
>XP_005261910
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   YFSLNTR 9
           YF LN R
Sbjct: 275 YFKLNAR 281
>XP_005261905
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   YFSLNTR 9
           YF LN R
Sbjct: 275 YFKLNAR 281
>XP_003846349
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS+N +
Sbjct: 129 SYFSINAK 136
>XP_006723893
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 781 YFDLNT 786
>XP_005260515
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 781 YFDLNT 786
>XP_006723892
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 782 YFDLNT 787
>XP_006723891
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 782 YFDLNT 787
>XP_006723890
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YFSLNT 8
           YF LNT
Sbjct: 782 YFDLNT 787
>XP_005269963
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TAYFSLNT 8
           T+Y S+NT
Sbjct: 161 TSYSSINT 168
>XP_005269962
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TAYFSLNT 8
           T+Y S+NT
Sbjct: 161 TSYSSINT 168
>XP_005252027
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY  LNT+
Sbjct: 181 AYLKLNTK 188
>XP_006717157
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AYFSLNTR 9
           AY  LNT+
Sbjct: 247 AYLKLNTK 254
>XP_005264092
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  AYFSLNTR 9
          +YF L+TR
Sbjct: 8  SYFPLSTR 15
>XP_003960959
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AYFSLNTR 9
           +YFS+N +
Sbjct: 129 SYFSINAK 136
>NP_001035552
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YFSLNTR 9
           YF+LN R
Sbjct: 388 YFTLNPR 394
>NP_001153181
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YFSLNTR 9
           YF+LN R
Sbjct: 263 YFTLNPR 269
>NP_004852
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   YFSLNTR 9
           YF LN R
Sbjct: 275 YFKLNAR 281
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.126    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,790
Number of extensions: 713
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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