Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     665
NP_653080                                                              19     665
XP_005267292                                                           19     665
XP_005267291                                                           19     665
XP_005267290                                                           19     665
NP_775897                                                              18    1935
NP_001159821                                                           18    1935
NP_001159820                                                           18    1935
NP_001159819                                                           18    1935
XP_006721897                                                           18    1935
XP_006721896                                                           18    1935
NP_112599                                                              16    5631
NP_705611                                                              16    7355
NP_055565                                                              16    7355
NP_001096046                                                           16    7355
NP_001139487                                                           16    7355
XP_006724873                                                           16    7355
NP_005426                                                              15    9605
NP_001003702                                                           15    9605
NP_066976                                                              15    9605
NP_001257957                                                           15    9605
XP_006726519                                                           15    9605
XP_006723226                                                           15    9605
XP_006722504                                                           15    9605
XP_006722503                                                           15    9605
XP_006716191                                                           15    9605
XP_006716190                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TAVGQARSD 9
            TAVGQA SD
Sbjct: 1621 TAVGQAHSD 1629
>NP_653080
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TAVGQARSD 9
            TAVGQA SD
Sbjct: 1523 TAVGQAHSD 1531
>XP_005267292
          Length = 1677

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TAVGQARSD 9
            TAVGQA SD
Sbjct: 1516 TAVGQAHSD 1524
>XP_005267291
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TAVGQARSD 9
            TAVGQA SD
Sbjct: 1523 TAVGQAHSD 1531
>XP_005267290
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TAVGQARSD 9
            TAVGQA SD
Sbjct: 1621 TAVGQAHSD 1629
>NP_775897
          Length = 606

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  TAVGQARS 8
          TA+GQARS
Sbjct: 6  TALGQARS 13
>NP_001159821
          Length = 606

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  TAVGQARS 8
          TA+GQARS
Sbjct: 6  TALGQARS 13
>NP_001159820
          Length = 606

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  TAVGQARS 8
          TA+GQARS
Sbjct: 6  TALGQARS 13
>NP_001159819
          Length = 606

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  TAVGQARS 8
          TA+GQARS
Sbjct: 6  TALGQARS 13
>XP_006721897
          Length = 630

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  TAVGQARS 8
          TA+GQARS
Sbjct: 6  TALGQARS 13
>XP_006721896
          Length = 630

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  TAVGQARS 8
          TA+GQARS
Sbjct: 6  TALGQARS 13
>NP_112599
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TAVGQARSD 9
          +A G+ARSD
Sbjct: 22 SAYGRARSD 30
>NP_705611
          Length = 78

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TAVGQARSD 9
          T +G+AR D
Sbjct: 12 TVLGEARGD 20
>NP_055565
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TAVGQAR 7
           TAVGQ R
Sbjct: 469 TAVGQTR 475
>NP_001096046
          Length = 78

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TAVGQARSD 9
          T +G+AR D
Sbjct: 12 TVLGEARGD 20
>NP_001139487
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TAVGQAR 7
           TAVGQ R
Sbjct: 469 TAVGQTR 475
>XP_006724873
          Length = 95

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TAVGQARSD 9
          T +G+AR D
Sbjct: 12 TVLGEARGD 20
>NP_005426
          Length = 1597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AVGQARS 8
           AVG+ARS
Sbjct: 389 AVGRARS 395
>NP_001003702
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AVGQARS 8
           AVG+ARS
Sbjct: 389 AVGRARS 395
>NP_066976
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VGQARSD 9
          +GQ RSD
Sbjct: 63 IGQLRSD 69
>NP_001257957
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VGQARSD 9
          +GQ RSD
Sbjct: 63 IGQLRSD 69
>XP_006726519
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AVGQARS 8
           AVG+ARS
Sbjct: 370 AVGRARS 376
>XP_006723226
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AVGQAR 7
           AVGQAR
Sbjct: 316 AVGQAR 321
>XP_006722504
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VGQARSD 9
          +GQ RSD
Sbjct: 63 IGQLRSD 69
>XP_006722503
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VGQARSD 9
          +GQ RSD
Sbjct: 63 IGQLRSD 69
>XP_006716191
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AVGQARS 8
           AVG+ARS
Sbjct: 389 AVGRARS 395
>XP_006716190
          Length = 1597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AVGQARS 8
           AVG+ARS
Sbjct: 389 AVGRARS 395
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.114    0.290 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 370,573
Number of extensions: 341
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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