Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1482
XP_005262424                                                           18    1482
NP_542194                                                              16    5631
NP_001275637                                                           16    5631
NP_940873                                                              16    5631
NP_954650                                                              16    5631
XP_006722781                                                           16    5631
XP_005272524                                                           16    5631
NP_001135389                                                           16    5631
NP_997191                                                              16    7355
NP_002909                                                              16    7355
NP_001152956                                                           16    7355
NP_001171864                                                           16    7355
NP_053586                                                              16    7355
NP_053584                                                              16    7355
NP_004874                                                              16    7355
NP_053585                                                              16    7355
XP_006722894                                                           16    7355
XP_006722893                                                           16    7355
XP_006722892                                                           16    7355
XP_006714873                                                           16    7355
XP_006714872                                                           16    7355
XP_006714871                                                           16    7355
XP_006711682                                                           16    7355
NP_001138890                                                           15    9605
NP_001269777                                                           15    9605
NP_835260                                                              15    9605
NP_690608                                                              15    9605
NP_004674                                                              15    9605
XP_006724234                                                           15    9605
XP_005261462                                                           15    9605
XP_006714523                                                           15    9605
XP_005248329                                                           15    9605
XP_005248328                                                           15    9605
XP_006714522                                                           15    9605
XP_006714521                                                           15    9605
XP_006714520                                                           15    9605
XP_005248327                                                           15    9605
XP_005248326                                                           15    9605
XP_006714519                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TASQTGQVS 9
            TASQTG VS
Sbjct: 1923 TASQTGLVS 1931
>XP_005262424
          Length = 2875

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TASQTGQVS 9
            TASQTG VS
Sbjct: 1718 TASQTGLVS 1726
>NP_542194
          Length = 1661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ASQTGQV 8
           A+QTGQV
Sbjct: 285 AAQTGQV 291
>NP_001275637
          Length = 158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TASQTGQV 8
          +ASQTG++
Sbjct: 5  SASQTGEI 12
>NP_940873
          Length = 821

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ASQTGQVS 9
           ASQTGQ +
Sbjct: 692 ASQTGQTA 699
>NP_954650
          Length = 1016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ASQTGQV 8
          A+QTGQV
Sbjct: 47 AAQTGQV 53
>XP_006722781
          Length = 821

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ASQTGQVS 9
           ASQTGQ +
Sbjct: 692 ASQTGQTA 699
>XP_005272524
          Length = 872

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ASQTGQVS 9
           ASQTGQ +
Sbjct: 743 ASQTGQTA 750
>NP_001135389
          Length = 1335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TASQTGQ 7
           TASQTG+
Sbjct: 566 TASQTGK 572
>NP_997191
          Length = 1888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TASQTGQVS 9
           TASQ GQ +
Sbjct: 322 TASQLGQTN 330
>NP_002909
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TASQTG 6
           TASQTG
Sbjct: 124 TASQTG 129
>NP_001152956
          Length = 1736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TASQTGQVS 9
           TASQ GQ +
Sbjct: 322 TASQLGQTN 330
>NP_001171864
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>NP_053586
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>NP_053584
          Length = 844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>NP_004874
          Length = 850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>NP_053585
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>XP_006722894
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TASQTG 6
          TASQTG
Sbjct: 15 TASQTG 20
>XP_006722893
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TASQTG 6
          TASQTG
Sbjct: 15 TASQTG 20
>XP_006722892
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TASQTG 6
           TASQTG
Sbjct: 124 TASQTG 129
>XP_006714873
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>XP_006714872
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQTGQV 8
           SQTGQV
Sbjct: 244 SQTGQV 249
>XP_006714871
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SQTGQV 8
          SQTGQV
Sbjct: 41 SQTGQV 46
>XP_006711682
          Length = 1739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TASQTGQVS 9
           TASQ GQ +
Sbjct: 173 TASQLGQTN 181
>NP_001138890
          Length = 2481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TASQTGQ 7
            TAS+TG+
Sbjct: 1840 TASETGE 1846
>NP_001269777
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QTGQVS 9
           QTGQ+S
Sbjct: 130 QTGQIS 135
>NP_835260
          Length = 2839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1252 TSVDTGQVS 1260
>NP_690608
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QTGQVS 9
           QTGQ+S
Sbjct: 183 QTGQIS 188
>NP_004674
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QTGQVS 9
           QTGQ+S
Sbjct: 183 QTGQIS 188
>XP_006724234
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TASQTGQ 7
            TAS+TG+
Sbjct: 1722 TASETGE 1728
>XP_005261462
          Length = 2473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TASQTGQ 7
            TAS+TG+
Sbjct: 1840 TASETGE 1846
>XP_006714523
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TASQTGQVS 9
           T+  TGQVS
Sbjct: 921 TSVDTGQVS 929
>XP_005248329
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1078 TSVDTGQVS 1086
>XP_005248328
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1078 TSVDTGQVS 1086
>XP_006714522
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1098 TSVDTGQVS 1106
>XP_006714521
          Length = 2781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1160 TSVDTGQVS 1168
>XP_006714520
          Length = 2802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1181 TSVDTGQVS 1189
>XP_005248327
          Length = 2839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1252 TSVDTGQVS 1260
>XP_005248326
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1252 TSVDTGQVS 1260
>XP_006714519
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TASQTGQVS 9
            T+  TGQVS
Sbjct: 1252 TSVDTGQVS 1260
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.286   0.0958    0.220 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,034
Number of extensions: 404
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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