Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              18    1135
NP_060773                                                              17    3301
XP_006715205                                                           17    3301
XP_006715204                                                           17    3301
NP_689537                                                              17    4312
NP_919226                                                              16    5631
NP_056516                                                              16    5631
NP_001120869                                                           16    5631
NP_065746                                                              16    5631
NP_001120870                                                           16    5631
XP_005259656                                                           16    5631
NP_115479                                                              16    5631
NP_002572                                                              16    7355
NP_006763                                                              16    7355
NP_689923                                                              16    7355
NP_443179                                                              16    7355
NP_001035502                                                           16    7355
NP_001035501                                                           16    7355
NP_079366                                                              16    7355
NP_976044                                                              16    7355
NP_001274320                                                           16    7355
NP_001035500                                                           16    7355
XP_005257601                                                           16    7355
XP_005257599                                                           16    7355
XP_005257600                                                           16    7355
XP_006717762                                                           16    7355
XP_005269672                                                           16    7355
XP_006717761                                                           16    7355
NP_000266                                                              15    9605
NP_003212                                                              15    9605
NP_055180                                                              15    9605
NP_689956                                                              15    9605
NP_001186346                                                           15    9605
NP_036430                                                              15    9605
NP_002801                                                              15    9605
NP_775808                                                              15    9605
XP_006725396                                                           15    9605
XP_006725395                                                           15    9605
XP_006725394                                                           15    9605
XP_006725393                                                           15    9605
XP_006722057                                                           15    9605
XP_006722056                                                           15    9605
XP_006722055                                                           15    9605
XP_006722054                                                           15    9605
XP_005268316                                                           15    9605
XP_005277669                                                           15    9605
XP_005277638                                                           15    9605
XP_005277637                                                           15    9605
XP_005277636                                                           15    9605
XP_005249702                                                           15    9605
XP_005249701                                                           15    9605
XP_005249700                                                           15    9605
XP_005249699                                                           15    9605
XP_006715720                                                           15    9605
XP_006715241                                                           15    9605
XP_006715240                                                           15    9605
XP_006715239                                                           15    9605
XP_006711527                                                           15    9605
XP_005245411                                                           15    9605
NP_001155971                                                           15    9605
NP_061720                                                              15    9605
NP_001003795                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA PQLSSE
Sbjct: 852 TASPQLSSE 860
>NP_060773
          Length = 924

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ALPQLSS 8
           ALPQLSS
Sbjct: 883 ALPQLSS 889
>XP_006715205
          Length = 924

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ALPQLSS 8
           ALPQLSS
Sbjct: 883 ALPQLSS 889
>XP_006715204
          Length = 924

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   ALPQLSS 8
           ALPQLSS
Sbjct: 883 ALPQLSS 889
>NP_689537
          Length = 151

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   ALPQLSSE 9
           ALPQ SSE
Sbjct: 96  ALPQKSSE 103
>NP_919226
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TALPQLS 7
            T+LPQLS
Sbjct: 1141 TSLPQLS 1147
>NP_056516
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALPQLSSE 9
          ALPQLS +
Sbjct: 33 ALPQLSDD 40
>NP_001120869
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALPQLSSE 9
          ALPQLS +
Sbjct: 33 ALPQLSDD 40
>NP_065746
          Length = 1221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           +ALP LSS+
Sbjct: 541 SALPSLSSD 549
>NP_001120870
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALPQLSSE 9
          ALPQLS +
Sbjct: 33 ALPQLSDD 40
>XP_005259656
          Length = 1373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           +ALP LSS+
Sbjct: 541 SALPSLSSD 549
>NP_115479
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TALPQLSS 8
          T LPQLS+
Sbjct: 63 TVLPQLSA 70
>NP_002572
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TALPQL 6
           TALPQL
Sbjct: 279 TALPQL 284
>NP_006763
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LPQLSSE 9
           LPQLS E
Sbjct: 700 LPQLSKE 706
>NP_689923
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PQLSSE 9
           PQLSSE
Sbjct: 138 PQLSSE 143
>NP_443179
          Length = 2170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PQLSSE 9
           PQLSSE
Sbjct: 297 PQLSSE 302
>NP_001035502
          Length = 1031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TALPQL 6
           TALPQL
Sbjct: 954 TALPQL 959
>NP_001035501
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TALPQL 6
           TALPQL
Sbjct: 929 TALPQL 934
>NP_079366
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TALPQ++ +
Sbjct: 782 TALPQVNED 790
>NP_976044
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TALPQL 6
            TALPQL
Sbjct: 1002 TALPQL 1007
>NP_001274320
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TALPQL 6
           TALPQL
Sbjct: 929 TALPQL 934
>NP_001035500
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TALPQL 6
           TALPQL
Sbjct: 967 TALPQL 972
>XP_005257601
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TALPQ++ +
Sbjct: 782 TALPQVNED 790
>XP_005257599
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TALPQ++ +
Sbjct: 782 TALPQVNED 790
>XP_005257600
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TALPQ++ +
Sbjct: 782 TALPQVNED 790
>XP_006717762
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  PQLSSE 9
          PQLSSE
Sbjct: 19 PQLSSE 24
>XP_005269672
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PQLSSE 9
           PQLSSE
Sbjct: 138 PQLSSE 143
>XP_006717761
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PQLSSE 9
           PQLSSE
Sbjct: 138 PQLSSE 143
>NP_000266
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TALPQLSS 8
          ++LPQ+SS
Sbjct: 79 SSLPQMSS 86
>NP_003212
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALPQLS 7
           ALPQLS
Sbjct: 128 ALPQLS 133
>NP_055180
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ALPQLSS 8
          ALP+LSS
Sbjct: 52 ALPRLSS 58
>NP_689956
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA+ QLSS+
Sbjct: 567 TAMGQLSSQ 575
>NP_001186346
          Length = 1491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>NP_036430
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LPQLSS 8
          LPQLSS
Sbjct: 88 LPQLSS 93
>NP_002801
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TALPQLSS 8
           T LP LSS
Sbjct: 273 TGLPDLSS 280
>NP_775808
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 741 LPQLSS 746
>XP_006725396
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006725395
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006725394
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006725393
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 238 AFPHLSSE 245
>XP_006722057
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006722056
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006722055
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006722054
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ALPQLSSE 9
           A P LSSE
Sbjct: 238 AFPHLSSE 245
>XP_005268316
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TALPQLSS 8
          ++LPQ+SS
Sbjct: 79 SSLPQMSS 86
>XP_005277669
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 741 LPQLSS 746
>XP_005277638
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 547 LPQLSS 552
>XP_005277637
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 670 LPQLSS 675
>XP_005277636
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 741 LPQLSS 746
>XP_005249702
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA+ QLSS+
Sbjct: 392 TAMGQLSSQ 400
>XP_005249701
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA+ QLSS+
Sbjct: 392 TAMGQLSSQ 400
>XP_005249700
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA+ QLSS+
Sbjct: 567 TAMGQLSSQ 575
>XP_005249699
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA+ QLSS+
Sbjct: 566 TAMGQLSSQ 574
>XP_006715720
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TALPQLSSE 9
           TA+ QLSS+
Sbjct: 567 TAMGQLSSQ 575
>XP_006715241
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALPQLS 7
           ALPQLS
Sbjct: 110 ALPQLS 115
>XP_006715240
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALPQLS 7
           ALPQLS
Sbjct: 110 ALPQLS 115
>XP_006715239
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ALPQLS 7
           ALPQLS
Sbjct: 128 ALPQLS 133
>XP_006711527
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TALPQLSS 8
           T LP LSS
Sbjct: 229 TGLPDLSS 236
>XP_005245411
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TALPQLSS 8
           T LP LSS
Sbjct: 276 TGLPDLSS 283
>NP_001155971
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 181 LPQLSS 186
>NP_061720
          Length = 4024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ALPQLS 7
          ALPQLS
Sbjct: 41 ALPQLS 46
>NP_001003795
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LPQLSS 8
           LPQLSS
Sbjct: 741 LPQLSS 746
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.109    0.264 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 599,576
Number of extensions: 604
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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