Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001191818                                                           17    4312
NP_000681                                                              17    4312
NP_060564                                                              16    7355
NP_001123479                                                           16    7355
NP_001123478                                                           16    7355
NP_002085                                                              16    7355
XP_005255332                                                           16    7355
XP_005255331                                                           16    7355
NP_219482                                                              15    9605
NP_001161880                                                           15    9605
NP_001161879                                                           15    9605
NP_055804                                                              15    9605
NP_001161881                                                           15    9605
NP_001161882                                                           15    9605
NP_001161883                                                           15    9605
NP_005214                                                              15    9605
NP_001207417                                                           15    9605
NP_001137251                                                           15    9605
NP_054774                                                              15    9605
NP_037534                                                              15    9605
NP_510882                                                              15    9605
NP_114146                                                              15    9605
NP_001019552                                                           15    9605
NP_001019551                                                           15    9605
NP_919274                                                              15    9605
NP_001230131                                                           15    9605
NP_001192246                                                           15    9605
NP_036548                                                              15    9605
XP_006721183                                                           15    9605
XP_005255205                                                           15    9605
XP_006720916                                                           15    9605
XP_006720915                                                           15    9605
XP_006716471                                                           15    9605
XP_005273714                                                           15    9605
XP_006715455                                                           15    9605
XP_006715453                                                           15    9605
XP_005248748                                                           15    9605
XP_005248747                                                           15    9605
XP_006715452                                                           15    9605
XP_006715451                                                           15    9605
XP_006715450                                                           15    9605
XP_005248745                                                           15    9605
XP_005248744                                                           15    9605
XP_005248743                                                           15    9605
XP_005248742                                                           15    9605
XP_006715449                                                           15    9605
XP_006715448                                                           15    9605
XP_006715447                                                           15    9605
XP_006715446                                                           15    9605
XP_005245313                                                           15    9605
NP_892015                                                              15    9605
NP_055562                                                              15    9605
NP_055770                                                              15    9605
NP_057019                                                              15    9605
NP_001248                                                              15    9605
NP_001207421                                                           15    9605
NP_001207420                                                           15    9605
NP_001207418                                                           15    9605
NP_001004758                                                           15    9605
>NP_001191818
          Length = 470

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TAIGKVLQV 9
           T IG+V+QV
Sbjct: 217 TEIGRVIQV 225
>NP_000681
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TAIGKVLQV 9
           T IG+V+QV
Sbjct: 264 TEIGRVIQV 272
>NP_060564
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIGKVLQV 9
           AIGKVL++
Sbjct: 616 AIGKVLKL 623
>NP_001123479
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIGKVLQV 9
           AIGKVL++
Sbjct: 487 AIGKVLKL 494
>NP_001123478
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIGKVLQV 9
           AIGKVL++
Sbjct: 624 AIGKVLKL 631
>NP_002085
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIGKVLQV 9
           AIGKVL++
Sbjct: 625 AIGKVLKL 632
>XP_005255332
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIGKVLQV 9
           AIGKVL++
Sbjct: 517 AIGKVLKL 524
>XP_005255331
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AIGKVLQV 9
           AIGKVL++
Sbjct: 518 AIGKVLKL 525
>NP_219482
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIGKVLQ 8
           A+G+VLQ
Sbjct: 418 AVGRVLQ 424
>NP_001161880
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 741 GKVLQV 746
>NP_001161879
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 936 GKVLQV 941
>NP_055804
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1616 GKVLQV 1621
>NP_001161881
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 684 GKVLQV 689
>NP_001161882
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 750 GKVLQV 755
>NP_001161883
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 143 GKVLQV 148
>NP_005214
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TAIGKVL 7
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>NP_001207417
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAIGKVLQV 9
           TA+GK L V
Sbjct: 135 TAVGKTLFV 143
>NP_001137251
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TAIGKVLQ 8
           T+IG+V+Q
Sbjct: 660 TSIGQVIQ 667
>NP_054774
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TAIGKVLQ 8
           T+IG+V+Q
Sbjct: 660 TSIGQVIQ 667
>NP_037534
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIGKVLQV 9
           A+GK+L V
Sbjct: 297 ALGKILSV 304
>NP_510882
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 175 TAVGKLL 181
>NP_114146
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>NP_001019552
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>NP_001019551
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>NP_919274
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 353 TAVGKLL 359
>NP_001230131
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TAIGKVLQ 8
           +AIGK+L+
Sbjct: 630 SAIGKILK 637
>NP_001192246
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 194 GKVLQV 199
>NP_036548
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TAIGKVLQ 8
           +AIGK+L+
Sbjct: 982 SAIGKILK 989
>XP_006721183
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TAIGKVLQV 9
          TA+GK L V
Sbjct: 88 TAVGKTLFV 96
>XP_005255205
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TAIGKVL 7
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>XP_006720916
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TAIGKVL 7
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>XP_006720915
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TAIGKVL 7
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>XP_006716471
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>XP_005273714
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TAIGKVL 7
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>XP_006715455
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 398 GKVLQV 403
>XP_006715453
          Length = 1337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1261 GKVLQV 1266
>XP_005248748
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1267 GKVLQV 1272
>XP_005248747
          Length = 1367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1291 GKVLQV 1296
>XP_006715452
          Length = 1474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1398 GKVLQV 1403
>XP_006715451
          Length = 1475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1399 GKVLQV 1404
>XP_006715450
          Length = 1498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1422 GKVLQV 1427
>XP_005248745
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1439 GKVLQV 1444
>XP_005248744
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1443 GKVLQV 1448
>XP_005248743
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1449 GKVLQV 1454
>XP_005248742
          Length = 1535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1459 GKVLQV 1464
>XP_006715449
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1463 GKVLQV 1468
>XP_006715448
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1473 GKVLQV 1478
>XP_006715447
          Length = 1574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1498 GKVLQV 1503
>XP_006715446
          Length = 1574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GKVLQV 9
            GKVLQV
Sbjct: 1498 GKVLQV 1503
>XP_005245313
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGKVLQV 9
           +G+VLQV
Sbjct: 146 VGRVLQV 152
>NP_892015
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 193 GKVLQV 198
>NP_055562
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GKVLQV 9
           GKVLQV
Sbjct: 234 GKVLQV 239
>NP_055770
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IGKVLQV 9
          +G+VLQV
Sbjct: 60 VGRVLQV 66
>NP_057019
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGKVLQV 9
           +G+VLQV
Sbjct: 146 VGRVLQV 152
>NP_001248
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TAIGKVLQV 9
          TA+GK L V
Sbjct: 88 TAVGKTLFV 96
>NP_001207421
          Length = 175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TAIGKVLQV 9
          TA+GK L V
Sbjct: 88 TAVGKTLFV 96
>NP_001207420
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TAIGKVLQV 9
          TA+GK L V
Sbjct: 88 TAVGKTLFV 96
>NP_001207418
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TAIGKVLQV 9
          TA+GK L V
Sbjct: 88 TAVGKTLFV 96
>NP_001004758
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IGKVLQ 8
           IGKVLQ
Sbjct: 228 IGKVLQ 233
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.136    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 371,754
Number of extensions: 541
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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