Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              19     869
NP_001120972                                                           19     869
XP_006716052                                                           19     869
XP_006716051                                                           19     869
NP_004477                                                              17    3301
XP_006721060                                                           17    3301
XP_005251989                                                           17    3301
XP_005251988                                                           17    3301
XP_005251987                                                           17    3301
NP_001164192                                                           17    4312
NP_001164188                                                           17    4312
NP_001164187                                                           17    4312
NP_055382                                                              17    4312
NP_001164186                                                           17    4312
NP_001164189                                                           17    4312
NP_001164185                                                           17    4312
NP_001164190                                                           17    4312
NP_001164191                                                           17    4312
XP_006721412                                                           17    4312
XP_005256317                                                           17    4312
XP_005256316                                                           17    4312
XP_005256315                                                           17    4312
XP_006721411                                                           17    4312
NP_001243497                                                           16    5631
NP_003612                                                              16    5631
NP_001243498                                                           16    5631
XP_006718416                                                           16    5631
XP_006718415                                                           16    5631
XP_006718414                                                           16    5631
XP_006718413                                                           16    5631
XP_005253234                                                           16    5631
XP_006718412                                                           16    5631
XP_005253233                                                           16    5631
XP_005253232                                                           16    5631
XP_005253231                                                           16    5631
NP_001103132                                                           16    7355
NP_054868                                                              15    9605
XP_006726692                                                           15    9605
XP_005250342                                                           15    9605
XP_006714166                                                           15    9605
XP_006714164                                                           15    9605
XP_006714163                                                           15    9605
XP_006714162                                                           15    9605
XP_006714161                                                           15    9605
XP_006714160                                                           15    9605
XP_005262823                                                           15    9605
XP_006710063                                                           15    9605
>NP_000236
          Length = 1390

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           TA IQSEVH
Sbjct: 151 TADIQSEVH 159
>NP_001120972
          Length = 1408

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           TA IQSEVH
Sbjct: 151 TADIQSEVH 159
>XP_006716052
          Length = 1409

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           TA IQSEVH
Sbjct: 170 TADIQSEVH 178
>XP_006716051
          Length = 1427

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           TA IQSEVH
Sbjct: 170 TADIQSEVH 178
>NP_004477
          Length = 1002

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           T+A+QSE H
Sbjct: 567 TSALQSEQH 575
>XP_006721060
          Length = 693

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+Q E+H
Sbjct: 399 AAVQGEIH 406
>XP_005251989
          Length = 975

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           T+A+QSE H
Sbjct: 540 TSALQSEQH 548
>XP_005251988
          Length = 1002

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           T+A+QSE H
Sbjct: 567 TSALQSEQH 575
>XP_005251987
          Length = 1029

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TAAIQSEVH 9
           T+A+QSE H
Sbjct: 594 TSALQSEQH 602
>NP_001164192
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 299 AAVQSAVH 306
>NP_001164188
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 527 AAVQSAVH 534
>NP_001164187
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 527 AAVQSAVH 534
>NP_055382
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 509 AAVQSAVH 516
>NP_001164186
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 527 AAVQSAVH 534
>NP_001164189
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 509 AAVQSAVH 516
>NP_001164185
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 555 AAVQSAVH 562
>NP_001164190
          Length = 868

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 507 AAVQSAVH 514
>NP_001164191
          Length = 722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 361 AAVQSAVH 368
>XP_006721412
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 462 AAVQSAVH 469
>XP_005256317
          Length = 841

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 480 AAVQSAVH 487
>XP_005256316
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 509 AAVQSAVH 516
>XP_005256315
          Length = 896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 535 AAVQSAVH 542
>XP_006721411
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AAIQSEVH 9
           AA+QS VH
Sbjct: 555 AAVQSAVH 562
>NP_001243497
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 152 TAALHSESH 160
>NP_003612
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 264 TAALHSESH 272
>NP_001243498
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 121 TAALHSESH 129
>XP_006718416
          Length = 784

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 121 TAALHSESH 129
>XP_006718415
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 187 TAALHSESH 195
>XP_006718414
          Length = 850

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 187 TAALHSESH 195
>XP_006718413
          Length = 887

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 264 TAALHSESH 272
>XP_005253234
          Length = 916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 264 TAALHSESH 272
>XP_006718412
          Length = 927

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 264 TAALHSESH 272
>XP_005253233
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 325 TAALHSESH 333
>XP_005253232
          Length = 948

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 325 TAALHSESH 333
>XP_005253231
          Length = 977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TAAIQSEVH 9
           TAA+ SE H
Sbjct: 325 TAALHSESH 333
>NP_001103132
          Length = 4284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    AIQSEVH 9
            A+QSE+H
Sbjct: 3080 ALQSELH 3086
>NP_054868
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AIQSEVH 9
           A+Q+E+H
Sbjct: 201 ALQAEIH 207
>XP_006726692
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   AIQSEVH 9
           A+Q E+H
Sbjct: 369 AVQGEIH 375
>XP_005250342
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AIQSEVH 9
           A+Q+E+H
Sbjct: 201 ALQAEIH 207
>XP_006714166
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_006714164
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714163
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714162
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714161
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 19 SIQSELH 25
>XP_006714160
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_005262823
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AIQSEVH 9
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_006710063
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   AIQSEVH 9
           A+Q E+H
Sbjct: 400 AVQGEIH 406
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.110    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 354,925
Number of extensions: 384
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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