Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     299
XP_005262424                                                           20     299
NP_659489                                                              17    2528
NP_054786                                                              17    2528
XP_006724683                                                           17    2528
XP_005273996                                                           17    2528
NP_542407                                                              17    3301
NP_001035290                                                           17    3301
NP_001035289                                                           17    3301
NP_001035273                                                           17    3301
NP_001035272                                                           17    3301
NP_001035271                                                           17    3301
NP_063948                                                              17    3301
XP_005276398                                                           17    3301
XP_006726550                                                           17    3301
XP_006723607                                                           17    3301
XP_005260724                                                           17    3301
XP_006716979                                                           17    3301
XP_003846435                                                           17    3301
XP_006716970                                                           17    3301
NP_060959                                                              17    4312
XP_005245394                                                           17    4312
XP_005245393                                                           17    4312
XP_006711515                                                           17    4312
XP_006711514                                                           17    4312
XP_006711513                                                           17    4312
XP_006717014                                                           16    5631
NP_001851                                                              16    5631
NP_077719                                                              16    7355
NP_001271151                                                           16    7355
NP_001091956                                                           16    7355
NP_002282                                                              16    7355
NP_001271153                                                           16    7355
NP_001271155                                                           16    7355
NP_001271154                                                           16    7355
NP_055789                                                              16    7355
NP_005513                                                              16    7355
NP_001116291                                                           16    7355
NP_001271149                                                           16    7355
XP_005252487                                                           16    7355
XP_005252486                                                           16    7355
XP_005252485                                                           16    7355
XP_005252484                                                           16    7355
XP_005252483                                                           16    7355
XP_006716417                                                           16    7355
XP_005246008                                                           16    7355
XP_005270959                                                           16    7355
XP_005270958                                                           16    7355
XP_006710730                                                           16    7355
NP_060561                                                              16    7355
NP_612442                                                              16    7355
NP_006623                                                              16    7355
NP_705873                                                              16    7355
NP_000825                                                              15    9605
NP_004647                                                              15    9605
NP_001269956                                                           15    9605
NP_060494                                                              15    9605
NP_001106995                                                           15    9605
NP_001026868                                                           15    9605
NP_001035947                                                           15    9605
NP_071890                                                              15    9605
NP_997274                                                              15    9605
NP_001269953                                                           15    9605
XP_006719393                                                           15    9605
XP_006719392                                                           15    9605
XP_006719391                                                           15    9605
XP_006719390                                                           15    9605
XP_006719389                                                           15    9605
XP_006719388                                                           15    9605
XP_006719387                                                           15    9605
XP_005270110                                                           15    9605
XP_006716660                                                           15    9605
XP_006715987                                                           15    9605
XP_005250029                                                           15    9605
XP_005250028                                                           15    9605
XP_005250027                                                           15    9605
XP_005247216                                                           15    9605
>NP_722576
          Length = 3080

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SYPLISTGV 9
            S+PLISTGV
Sbjct: 2192 SFPLISTGV 2200
>XP_005262424
          Length = 2875

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SYPLISTGV 9
            S+PLISTGV
Sbjct: 1987 SFPLISTGV 1995
>NP_659489
          Length = 309

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YPLISTG 8
           YP++STG
Sbjct: 238 YPILSTG 244
>NP_054786
          Length = 325

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYPLISTGV 9
           ++P ISTGV
Sbjct: 263 AFPCISTGV 271
>XP_006724683
          Length = 195

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YPLISTG 8
           YP++STG
Sbjct: 124 YPILSTG 130
>XP_005273996
          Length = 334

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SYPLISTGV 9
           ++P ISTGV
Sbjct: 263 AFPCISTGV 271
>NP_542407
          Length = 425

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYPLISTGV 9
           ++P ISTG+
Sbjct: 181 AFPCISTGI 189
>NP_001035290
          Length = 158

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YPLISTGV 9
          YP I+TG+
Sbjct: 73 YPTIATGI 80
>NP_001035289
          Length = 253

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPLISTGV 9
           YP I+TG+
Sbjct: 168 YPTIATGI 175
>NP_001035273
          Length = 253

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPLISTGV 9
           YP I+TG+
Sbjct: 168 YPTIATGI 175
>NP_001035272
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPLISTGV 9
           YP I+TG+
Sbjct: 191 YPTIATGI 198
>NP_001035271
          Length = 253

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPLISTGV 9
           YP I+TG+
Sbjct: 168 YPTIATGI 175
>NP_063948
          Length = 253

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPLISTGV 9
           YP I+TG+
Sbjct: 168 YPTIATGI 175
>XP_005276398
          Length = 150

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPLISTG 8
           YPL+ TG
Sbjct: 136 YPLVGTG 142
>XP_006726550
          Length = 103

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  YPLISTG 8
          YPL+ TG
Sbjct: 89 YPLVGTG 95
>XP_006723607
          Length = 447

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYPLISTGV 9
           ++P ISTG+
Sbjct: 181 AFPCISTGI 189
>XP_005260724
          Length = 448

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SYPLISTGV 9
           ++P ISTG+
Sbjct: 181 AFPCISTGI 189
>XP_006716979
          Length = 150

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPLISTG 8
           YPL+ TG
Sbjct: 136 YPLVGTG 142
>XP_003846435
          Length = 150

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPLISTG 8
           YPL+ TG
Sbjct: 136 YPLVGTG 142
>XP_006716970
          Length = 103

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  YPLISTG 8
          YPL+ TG
Sbjct: 89 YPLVGTG 95
>NP_060959
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SYPLISTG 8
            S+PL STG
Sbjct: 1370 SFPLSSTG 1377
>XP_005245394
          Length = 1741

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SYPLISTG 8
            S+PL STG
Sbjct: 1370 SFPLSSTG 1377
>XP_005245393
          Length = 2663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SYPLISTG 8
            S+PL STG
Sbjct: 1370 SFPLSSTG 1377
>XP_006711515
          Length = 2904

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SYPLISTG 8
            S+PL STG
Sbjct: 1370 SFPLSSTG 1377
>XP_006711514
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SYPLISTG 8
            S+PL STG
Sbjct: 1370 SFPLSSTG 1377
>XP_006711513
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SYPLISTG 8
            S+PL STG
Sbjct: 1370 SFPLSSTG 1377
>XP_006717014
          Length = 199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYPLIST 7
           +YPL+ST
Sbjct: 192 AYPLLST 198
>NP_001851
          Length = 143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYPLIST 7
           +YPL+ST
Sbjct: 136 AYPLLST 142
>NP_077719
          Length = 2471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SYPLIS 6
            SYPL+S
Sbjct: 1660 SYPLVS 1665
>NP_001271151
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 358 PLVSSGV 364
>NP_001091956
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SYPLIST 7
           SYP IST
Sbjct: 258 SYPWIST 264
>NP_002282
          Length = 1786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SYPLISTG 8
           S+P ISTG
Sbjct: 173 SFPGISTG 180
>NP_001271153
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 253 PLVSSGV 259
>NP_001271155
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 280 PLVSSGV 286
>NP_001271154
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 253 PLVSSGV 259
>NP_055789
          Length = 1556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP I TG+
Sbjct: 770 YPFIRTGL 777
>NP_005513
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  YPLISTG 8
          YP++S+G
Sbjct: 12 YPILSSG 18
>NP_001116291
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYPLISTG 8
           S P++STG
Sbjct: 904 SLPVVSTG 911
>NP_001271149
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 300 PLVSSGV 306
>XP_005252487
          Length = 919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP I TG+
Sbjct: 133 YPFIRTGL 140
>XP_005252486
          Length = 1407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP I TG+
Sbjct: 611 YPFIRTGL 618
>XP_005252485
          Length = 1622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP I TG+
Sbjct: 826 YPFIRTGL 833
>XP_005252484
          Length = 1566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP I TG+
Sbjct: 770 YPFIRTGL 777
>XP_005252483
          Length = 1612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP I TG+
Sbjct: 826 YPFIRTGL 833
>XP_006716417
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 253 PLVSSGV 259
>XP_005246008
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SYPLISTG 8
           S P++STG
Sbjct: 904 SLPVVSTG 911
>XP_005270959
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SYPLIS 6
            SYPL+S
Sbjct: 1621 SYPLVS 1626
>XP_005270958
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SYPLIS 6
            SYPL+S
Sbjct: 1621 SYPLVS 1626
>XP_006710730
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SYPLIS 6
            SYPL+S
Sbjct: 1621 SYPLVS 1626
>NP_060561
          Length = 547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           PL+S+GV
Sbjct: 372 PLVSSGV 378
>NP_612442
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPLISTGV 9
           +PL STGV
Sbjct: 569 FPLGSTGV 576
>NP_006623
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SYPLIST 7
           SYP IST
Sbjct: 180 SYPWIST 186
>NP_705873
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  YPLISTG 8
          YP++S+G
Sbjct: 12 YPILSSG 18
>NP_000825
          Length = 1484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SYPLISTGV 9
           S P I TG+
Sbjct: 526 SVPFIETGI 534
>NP_004647
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PLISTGV 9
           P+ISTG+
Sbjct: 555 PVISTGL 561
>NP_001269956
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   YPLISTG 8
           YP I TG
Sbjct: 95  YPCIETG 101
>NP_060494
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   YPLISTG 8
           YP I TG
Sbjct: 163 YPCIETG 169
>NP_001106995
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SYPLISTG 8
           ++P+I TG
Sbjct: 203 TFPMIGTG 210
>NP_001026868
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 542 YPAVSTDV 549
>NP_001035947
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PLISTG 8
          PL+STG
Sbjct: 10 PLLSTG 15
>NP_071890
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PLISTG 8
          PL+STG
Sbjct: 10 PLLSTG 15
>NP_997274
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PLISTGV 9
           PL+ TGV
Sbjct: 111 PLVRTGV 117
>NP_001269953
          Length = 145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   YPLISTG 8
           YP I TG
Sbjct: 103 YPCIETG 109
>XP_006719393
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 515 YPAVSTDV 522
>XP_006719392
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 523 YPAVSTDV 530
>XP_006719391
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 542 YPAVSTDV 549
>XP_006719390
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 550 YPAVSTDV 557
>XP_006719389
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 550 YPAVSTDV 557
>XP_006719388
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 604 YPAVSTDV 611
>XP_006719387
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPLISTGV 9
           YP +ST V
Sbjct: 604 YPAVSTDV 611
>XP_005270110
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PLISTG 8
           PL+STG
Sbjct: 435 PLLSTG 440
>XP_006716660
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   YPLISTG 8
           YP I TG
Sbjct: 163 YPCIETG 169
>XP_006715987
          Length = 170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PLISTG 8
          PL+STG
Sbjct: 10 PLLSTG 15
>XP_005250029
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PLISTG 8
          PL+STG
Sbjct: 10 PLLSTG 15
>XP_005250028
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PLISTG 8
          PL+STG
Sbjct: 10 PLLSTG 15
>XP_005250027
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PLISTG 8
          PL+STG
Sbjct: 10 PLLSTG 15
>XP_005247216
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SYPLISTG 8
           ++P+I TG
Sbjct: 203 TFPMIGTG 210
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.135    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 532,249
Number of extensions: 854
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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