Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     390
XP_006713721                                                           20     390
NP_001005499                                                           17    3301
NP_001139395                                                           16    5631
NP_057422                                                              16    5631
NP_001128251                                                           16    5631
NP_114475                                                              16    7355
NP_061742                                                              16    7355
NP_001124388                                                           15    9605
NP_004603                                                              15    9605
NP_001005497                                                           15    9605
NP_473445                                                              15    9605
NP_110447                                                              15    9605
NP_940968                                                              15    9605
NP_079375                                                              15    9605
NP_005934                                                              15    9605
NP_054815                                                              15    9605
NP_001265135                                                           15    9605
NP_001265130                                                           15    9605
NP_060081                                                              15    9605
NP_955361                                                              15    9605
NP_001068566                                                           15    9605
XP_006721642                                                           15    9605
XP_006721641                                                           15    9605
XP_006721640                                                           15    9605
XP_005252207                                                           15    9605
XP_006715287                                                           15    9605
XP_006715286                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SYIFVSVTE 9
          SYIFVSVT+
Sbjct: 67 SYIFVSVTQ 75
>XP_006713721
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SYIFVSVTE 9
          SYIFVSVT+
Sbjct: 67 SYIFVSVTQ 75
>NP_001005499
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YIFVSVTE 9
           YIF+ VTE
Sbjct: 102 YIFLGVTE 109
>NP_001139395
          Length = 1154

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YIFVSVTE 9
          YIF ++TE
Sbjct: 5  YIFCNITE 12
>NP_057422
          Length = 975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YIFVSVTE 9
           YIF+S TE
Sbjct: 713 YIFLSSTE 720
>NP_001128251
          Length = 1015

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YIFVSVTE 9
           YIF+S TE
Sbjct: 753 YIFLSSTE 760
>NP_114475
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYIFVSVTE 9
           +Y FV +TE
Sbjct: 278 TYSFVKITE 286
>NP_061742
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SYIFVSVTE 9
           +Y FV +TE
Sbjct: 278 TYSFVKITE 286
>NP_001124388
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FVSVTE 9
          FVSVTE
Sbjct: 55 FVSVTE 60
>NP_004603
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FVSVTE 9
          FVSVTE
Sbjct: 55 FVSVTE 60
>NP_001005497
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YIFVSVTE 9
           +IF+ VTE
Sbjct: 102 FIFLGVTE 109
>NP_473445
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YIFVSVTE 9
           +IF+ VTE
Sbjct: 101 FIFMGVTE 108
>NP_110447
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SYIFVS 6
           SY+FVS
Sbjct: 280 SYVFVS 285
>NP_940968
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YIFVSVTE 9
           +IF+ +TE
Sbjct: 96  HIFIDITE 103
>NP_079375
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SYIFVSVTE 9
          SY FVSV +
Sbjct: 64 SYSFVSVQD 72
>NP_005934
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SYIFVSVTE 9
          SY+ +S+TE
Sbjct: 70 SYLRISLTE 78
>NP_054815
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYIFVSV 7
           S+IF+SV
Sbjct: 189 SFIFISV 195
>NP_001265135
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYIFVSV 7
           S+IF+SV
Sbjct: 202 SFIFISV 208
>NP_001265130
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYIFVSV 7
           S+IF+SV
Sbjct: 189 SFIFISV 195
>NP_060081
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYIFVSV 7
           S+IF+SV
Sbjct: 189 SFIFISV 195
>NP_955361
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYIFVSV 7
           S+IF+SV
Sbjct: 189 SFIFISV 195
>NP_001068566
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SYIFVSVTE 9
          SY+ +S+TE
Sbjct: 70 SYLRISLTE 78
>XP_006721642
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SYIFVSVTE 9
          SY FVSV +
Sbjct: 64 SYSFVSVQD 72
>XP_006721641
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SYIFVSVTE 9
          SY FVSV +
Sbjct: 64 SYSFVSVQD 72
>XP_006721640
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SYIFVSVTE 9
          SY FVSV +
Sbjct: 64 SYSFVSVQD 72
>XP_005252207
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FVSVTE 9
          FVSVTE
Sbjct: 55 FVSVTE 60
>XP_006715287
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SYIFVS 6
           SY+FVS
Sbjct: 280 SYVFVS 285
>XP_006715286
          Length = 945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SYIFVS 6
           SY+FVS
Sbjct: 280 SYVFVS 285
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.132    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 347,256
Number of extensions: 461
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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