Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005266090                                                           20     390
XP_005266089                                                           20     390
XP_005266088                                                           20     390
XP_005266086                                                           20     390
NP_904357                                                              20     390
NP_005912                                                              19     869
XP_005248577                                                           19     869
XP_005248576                                                           19     869
NP_001269676                                                           18    1935
NP_001269674                                                           18    1935
NP_775104                                                              18    1935
XP_005252438                                                           18    1935
XP_005252437                                                           18    1935
NP_006039                                                              17    3301
NP_001099032                                                           17    3301
XP_005263479                                                           17    3301
NP_055972                                                              17    4312
NP_001138231                                                           17    4312
NP_001138230                                                           17    4312
XP_005271534                                                           17    4312
XP_005271532                                                           17    4312
XP_006718867                                                           17    4312
XP_005271531                                                           17    4312
XP_005271530                                                           17    4312
XP_005271529                                                           17    4312
XP_006718866                                                           17    4312
XP_005271528                                                           17    4312
XP_006718865                                                           17    4312
XP_005271527                                                           17    4312
XP_005271526                                                           17    4312
XP_006718864                                                           17    4312
XP_005271525                                                           17    4312
XP_006718863                                                           17    4312
XP_006718862                                                           17    4312
XP_006718861                                                           17    4312
XP_006718860                                                           17    4312
XP_006718859                                                           17    4312
XP_005277737                                                           17    4312
NP_001191070                                                           16    5631
XP_006722523                                                           16    5631
XP_005258321                                                           16    5631
NP_001001331                                                           16    7355
NP_001258640                                                           16    7355
NP_055395                                                              16    7355
NP_001258641                                                           16    7355
NP_001129588                                                           16    7355
NP_775792                                                              16    7355
NP_001074020                                                           16    7355
NP_001674                                                              16    7355
XP_005252006                                                           16    7355
XP_006717148                                                           16    7355
XP_006717147                                                           16    7355
XP_006717040                                                           16    7355
XP_006717039                                                           16    7355
XP_006717038                                                           16    7355
XP_005251795                                                           16    7355
XP_006717037                                                           16    7355
XP_005265965                                                           16    7355
XP_006713245                                                           16    7355
XP_006713244                                                           16    7355
XP_006713243                                                           16    7355
XP_006713242                                                           16    7355
XP_006713241                                                           16    7355
XP_006713240                                                           16    7355
XP_006713239                                                           16    7355
XP_005265236                                                           16    7355
XP_006713238                                                           16    7355
NP_055761                                                              15    9605
NP_955468                                                              15    9605
NP_001299                                                              15    9605
NP_828847                                                              15    9605
NP_001243352                                                           15    9605
NP_116289                                                              15    9605
NP_001191229                                                           15    9605
NP_001243624                                                           15    9605
XP_005264573                                                           15    9605
NP_115865                                                              15    9605
>XP_005266090
          Length = 300

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YHLALIFK 9
           YHLAL+FK
Sbjct: 264 YHLALLFK 271
>XP_005266089
          Length = 345

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YHLALIFK 9
           YHLAL+FK
Sbjct: 309 YHLALLFK 316
>XP_005266088
          Length = 350

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YHLALIFK 9
           YHLAL+FK
Sbjct: 340 YHLALLFK 347
>XP_005266086
          Length = 376

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YHLALIFK 9
           YHLAL+FK
Sbjct: 340 YHLALLFK 347
>NP_904357
          Length = 367

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YHLALIFK 9
           YHLAL+FK
Sbjct: 331 YHLALLFK 338
>NP_005912
          Length = 1512

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SYHLALIFK 9
            S HLALIFK
Sbjct: 1455 SNHLALIFK 1463
>XP_005248577
          Length = 1349

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SYHLALIFK 9
            S HLALIFK
Sbjct: 1292 SNHLALIFK 1300
>XP_005248576
          Length = 1375

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SYHLALIFK 9
            S HLALIFK
Sbjct: 1318 SNHLALIFK 1326
>NP_001269676
          Length = 609

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YH AL+FK
Sbjct: 533 YHRALLFK 540
>NP_001269674
          Length = 865

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YH AL+FK
Sbjct: 789 YHRALLFK 796
>NP_775104
          Length = 872

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YH AL+FK
Sbjct: 796 YHRALLFK 803
>XP_005252438
          Length = 784

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YH AL+FK
Sbjct: 708 YHRALLFK 715
>XP_005252437
          Length = 807

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YH AL+FK
Sbjct: 731 YHRALLFK 738
>NP_006039
          Length = 1173

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YH++ IFK
Sbjct: 865 YHISTIFK 872
>NP_001099032
          Length = 1302

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YHLALIFK 9
            YH++ IFK
Sbjct: 994  YHISTIFK 1001
>XP_005263479
          Length = 1353

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YHLALIFK 9
            YH++ IFK
Sbjct: 1045 YHISTIFK 1052
>NP_055972
          Length = 1377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 291 SYHLAL 296
>NP_001138231
          Length = 1319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 291 SYHLAL 296
>NP_001138230
          Length = 1377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 291 SYHLAL 296
>XP_005271534
          Length = 706

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271532
          Length = 858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718867
          Length = 926

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271531
          Length = 1365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271530
          Length = 1376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271529
          Length = 1391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718866
          Length = 1408

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271528
          Length = 1412

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718865
          Length = 1419

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271527
          Length = 1423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271526
          Length = 1427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718864
          Length = 1434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_005271525
          Length = 1438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718863
          Length = 1455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718862
          Length = 1466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718861
          Length = 1481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718860
          Length = 1538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 337 SYHLAL 342
>XP_006718859
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 290 SYHLAL 295
>XP_005277737
          Length = 1585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           SYHLAL
Sbjct: 336 SYHLAL 341
>NP_001191070
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YHLAL +K
Sbjct: 545 YHLALDWK 552
>XP_006722523
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YHLAL +K
Sbjct: 620 YHLALDWK 627
>XP_005258321
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YHLALIFK 9
           YHLAL +K
Sbjct: 646 YHLALDWK 653
>NP_001001331
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 961 YQLALIF 967
>NP_001258640
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYHLALI 7
           S+HLAL+
Sbjct: 242 SFHLALL 248
>NP_055395
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYHLALI 7
           S+HLAL+
Sbjct: 242 SFHLALL 248
>NP_001258641
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SYHLALI 7
          S+HLAL+
Sbjct: 79 SFHLALL 85
>NP_001129588
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SYHLALI 7
           SYH ALI
Sbjct: 382 SYHSALI 388
>NP_775792
          Length = 1444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YHLALIF 8
           +HLALI+
Sbjct: 975 HHLALIY 981
>NP_001074020
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YHLALIF 8
           +HLALI+
Sbjct: 936 HHLALIY 942
>NP_001674
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 916 YQLALIF 922
>XP_005252006
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SYHLALI 7
          S+HLAL+
Sbjct: 79 SFHLALL 85
>XP_006717148
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYHLALI 7
           S+HLAL+
Sbjct: 178 SFHLALL 184
>XP_006717147
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SYHLALI 7
           S+HLAL+
Sbjct: 242 SFHLALL 248
>XP_006717040
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YHLALIF 8
            +HLALI+
Sbjct: 1039 HHLALIY 1045
>XP_006717039
          Length = 1370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YHLALIF 8
           +HLALI+
Sbjct: 901 HHLALIY 907
>XP_006717038
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YHLALIF 8
            +HLALI+
Sbjct: 1004 HHLALIY 1010
>XP_005251795
          Length = 1508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YHLALIF 8
            +HLALI+
Sbjct: 1039 HHLALIY 1045
>XP_006717037
          Length = 1508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YHLALIF 8
            +HLALI+
Sbjct: 1039 HHLALIY 1045
>XP_005265965
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SYHLALI 7
           SYH ALI
Sbjct: 382 SYHSALI 388
>XP_006713245
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 930 YQLALIF 936
>XP_006713244
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 916 YQLALIF 922
>XP_006713243
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 961 YQLALIF 967
>XP_006713242
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 961 YQLALIF 967
>XP_006713241
          Length = 1212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 930 YQLALIF 936
>XP_006713240
          Length = 1232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 950 YQLALIF 956
>XP_006713239
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 961 YQLALIF 967
>XP_005265236
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 961 YQLALIF 967
>XP_006713238
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YHLALIF 8
           Y LALIF
Sbjct: 961 YQLALIF 967
>NP_055761
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SYHLALIF 8
          ++HL L+F
Sbjct: 68 AFHLGLLF 75
>NP_955468
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SYHLALIF 8
          ++HL L+F
Sbjct: 68 AFHLGLLF 75
>NP_001299
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  HLALIFK 9
          HL L+FK
Sbjct: 10 HLLLLFK 16
>NP_828847
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YHLALIFK 9
           YH  +IFK
Sbjct: 232 YHSDIIFK 239
>NP_001243352
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYHLALIF 8
           +Y+LAL+F
Sbjct: 255 AYNLALMF 262
>NP_116289
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYHLALIF 8
           +Y+LAL+F
Sbjct: 264 AYNLALMF 271
>NP_001191229
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SYHLALIF 8
           +Y+LAL+F
Sbjct: 264 AYNLALMF 271
>NP_001243624
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SYHLAL 6
           +YHLAL
Sbjct: 596 AYHLAL 601
>XP_005264573
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SYHLALIF 8
          ++HL L+F
Sbjct: 68 AFHLGLLF 75
>NP_115865
          Length = 125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  YHLALIFK 9
          Y LALI K
Sbjct: 4  YELALILK 11
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.148    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 543,122
Number of extensions: 613
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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